Patents by Inventor William Kiesman

William Kiesman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Crystalline Forms
    Publication number: 20220098150
    Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[2-fluorophenyl)methyl]oxy}phenyl-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.
    Type: Application
    Filed: May 17, 2021
    Publication date: March 31, 2022
    Inventors: Nishanth Gopinathan, Erwin Irdam, William Kiesman, Daw-long A. Kwok, Yiqing Lin, Frederick Osei-Yeboah, Matthew Peterson, Kenny Tran, Kalyan Vasudevan
  • NOVEL CRYSTALLINE FORMS
    Publication number: 20200062705
    Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.
    Type: Application
    Filed: May 18, 2018
    Publication date: February 27, 2020
    Inventors: Nishanth Gopinathan, Erwin Irdam, William Kiesman, Daw-long A. Kwok, Yiqing Lin, Frederick Osei-Yeboah, Matthew Peterson, Kenny Tran, Kalyan Vasudevan
  • Process for preparing alpha-carboxamide pyrrolidine derivatives
    Patent number: 10421716
    Abstract: The invention relates to a novel process for preparing ?-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: September 24, 2019
    Assignee: Convergence Pharmaceuticals Limited
    Inventors: David MacPherson, David Witty, Gerard Giblin, Michael Williams, Donald Walker, William Kiesman, Tamera Mack
  • Process for Preparing Alpha-Carboxamide Pyrrolidine Derivatives
    Publication number: 20170369437
    Abstract: The invention relates to a novel process for preparing ?-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Application
    Filed: December 23, 2015
    Publication date: December 28, 2017
    Inventors: David MacPherson, David WITTY, Gerard GIBLIN, Michael WILLIAMS, Donald WALKER, William KIESMAN, Tamera MACK
  • Process for preparing high purity and crystalline dimethyl fumarate
    Patent number: 9422226
    Abstract: The present invention describes a process for the preparation of dimethyl fumarate. The process involves the esterification of fumaric acid and methanol in the presence of sulfuric acid as an acid catalyst. The high purity dimethyl fumarate contains no more than trace amounts of dimethyl sulfate. The present invention also provides a process for the preparation of highly pure dimethyl fumarate with a particle size from 20 to 250???.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: August 23, 2016
    Assignee: Biogen MA Inc.
    Inventors: John Guzowski, William Kiesman, Erwin Irdham
  • Process for Preparing High Purity and Crystalline Dimethyl Fumarate
    Publication number: 20140200363
    Abstract: The present invention describes a process for the preparation of dimethyl fumarate. The process involves the esterification of fumaric acid and methanol in the presence of sulfuric acid as an acid catalyst. The high purity dimethyl fumarate contains no more than trace amounts of dimethyl sulfate. The present invention also provides a process for the preparation of highly pure dimethyl fumarate with a particle size from 20 to 250???.
    Type: Application
    Filed: June 8, 2012
    Publication date: July 17, 2014
    Applicant: Biogen IDEC MA Inc.
    Inventors: John Guzowski, William Kiesman, Erwin Irdam
  • Adenosine receptor antagonists and methods of making and using the same
    Publication number: 20070015732
    Abstract: The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable.
    Type: Application
    Filed: July 13, 2006
    Publication date: January 18, 2007
    Inventors: William Kiesman, Carol Ensinger, Russell Petter, James Dowling, Gnanasambandam Kumaravel, He Chang, Ko Lin
  • Adenosine receptor antagonists and methods of making and using the same
    Publication number: 20060252730
    Abstract: The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable.
    Type: Application
    Filed: July 10, 2006
    Publication date: November 9, 2006
    Inventors: William Kiesman, Carol Ensinger, Russell Petter, James Dowling, Gnanasambandam Kumaravel, He Xi Chang, Ko Chung Lin