Abstract: Systems, apparatuses, and methods disclosed for providing a marketplace platform that allows users to enter into risk transfer smart contracts to secure and provide financial coverage against the possible damage and losses that may occur from environmental conditions or events. Embodiments function to help close the large coverage gap that exists in the market for asset owners and to allow those asset owners with either hard-to-insure assets or with hard-to-insure client profiles an option for coverage against the effects of environmental conditions or events that are parametrically measured. An exemplary embodiment of this disclosure is focused on elevated space weather conditions.

Abstract: An example hydraulic system has: a hydraulic cylinder actuator having a cylinder and a piston axially movable in the cylinder, wherein the piston has a piston head that divides an internal space of the cylinder into a first chamber and a second chamber; a fluid reservoir; a pilot pressure source that generates a pilot fluid signal; and a valve assembly controlling fluid flow to and from the hydraulic cylinder actuator, wherein the valve assembly has a first workport fluidly coupled to the first chamber, a second workport fluidly coupled to the second chamber, a reservoir port fluidly coupled to the fluid reservoir, and a pilot port fluidly coupled to the pilot pressure source to receive the pilot fluid signal, wherein the pilot fluid signal actuates the valve assembly to fluidly couple the first workport and the second workport to the reservoir port, thereby operating the piston in a float mode.

Abstract: A system for determining autonomous actions of a digital persona includes a desire subsystem configured to identify a desire of the digital persona based upon a priority value of the desire determined using a state of the digital persona, and an intent subsystem configured to select a subset of intents with outcomes that are predicted to reduce the priority value of the desire. The system also includes a goal-setting subsystem configured to map the subset of intents to one or more goals with outcomes matching the outcomes of the subset of intents, a planning subsystem configured to determine a set of plan elements for achieving the one or more goals, an action subsystem configured to initiate or perform the set of plan elements, and a sensory subsystem configured to receive feedback and update the state associated with the digital persona.

Abstract: Systems, apparatus, interfaces, methods, and articles of manufacture that provide for proactive weather awareness and actions.

Abstract: Systems, apparatus, interfaces, methods, and articles of manufacture that provide for proactive weather awareness and actions.

Abstract: In a gaming system, a first player and one or more second player(s) contribute respective player reels. At least one game outcome is determined from an array of symbols randomly generated from the combination of the player reels. The at least one game outcome is shared by all players and used to determine awards for all players. The first player may subsequently join one or more third player(s) to determine new game outcomes from a new combination of player reels. In another gaming system, players select a combination of player reels from a pool of player reels to compete against each other. At least one game outcome is determined for each player from an array of symbols randomly generated from the player's selected subset of player reels. The players are ranked according to the game outcomes for the players, and awards are determined for the players according to the ranking.

Abstract: The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A?-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid ? 1-42.

Abstract: The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A?-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid ? 1-42.

Abstract: The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A?-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid ? 1-42.

Abstract: The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A?-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid ?1-42.

Abstract: The present invention relates to methods for enhancing the cellular uptake and clearance of soluble oligomeric A? peptide assemblies from the environment surrounding both neuronal and non-neuronal cells. Oligomeric A? peptide assembly uptake and clearance is achieved via an agent that enhances insulin receptor signaling. Such ADDL uptake enhancers represent effective anti-ADDL therapeutics for use in the therapeutic treatment and/or prophylactic treatment of diseases including Alzheimer's disease, Down's syndrome, and the like, in which compromised nerve cell function is linked to the formation and/or the activity of soluble oligomeric A? peptide assemblies, also known as ADDLs, and ADDL-related assemblies.

Abstract: Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid ? (Abeta) and methods of employing those antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution.

Abstract: The present invention provides amyloid ? peptide assemblies composed of at least three amyloid ? peptide subunits, wherein at least one of the amyloid ? peptide subunits is an amyloid ? peptide analog. The invention further relates to metal complexes of amyloid ? peptide assemblies and the use of amyloid ? peptide assemblies as vaccines and in the identification of agents that modulate assembly of the amyloid ? peptide subunits.

Abstract: Embodiments provide mechanisms and methods for measuring shooting performance in multiplayer environments. These mechanisms and methods include automatic synchronization that enables sensors associated with multiple players to interact with one or more control consoles in a common playing area free of interference. The ability to associate sensors to interact with one or more control consoles in a common playing area free of interference make it possible for coaches and players to measure levels of play, build teamwork among multiple players, improve and maintain skills, select players to meet game situations and team requirements, make decisions on player roles, and use playing environment space more efficiently.

Abstract: The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid ? protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes.

Abstract: The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A?-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid ?1-42.

Abstract: A media feeding apparatus includes a side wall, the side wall having a first side surface and an opposite side surface. A sheet picking mechanism has a pick arm and a pick roller. The pick arm is configured to mount the pick roller. The pick arm has a pivot axis substantially perpendicular to the side wall. A restraint is mounted to the pick arm, wherein at least the first side surface of the side wall is in close proximity to the restraint.

Abstract: The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid ? protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.

Abstract: The invention described in this disclosure involves a new composition of matter, amyloid beta-derived dementing ligands (ADDL's). ADDLs consist of amyloid ? peptide assembled into soluble globular non-fibrillar oligomeric structures that are capable of activating specific cellular processes. The invention further encompasses methods for assaying the formation, presence, receptor protein binding and cellular activities of ADDLs. The invention further encompasses assay methods and inhibitor molecules for cellular signaling molecules activated by ADDLs. Also described are molecules that block proteins that promote the formation of ADDLs.

Abstract: Embodiments of the present invention provide mechanisms and methods for measuring shooting performance. These mechanisms and methods for measuring shooting performance make it possible for coaches and players to obtain information they need to measure levels of play, improve and maintain skills, select players to meet game situations and team requirements, and make decisions on player roles.