Patents by Inventor William Kovacs
William Kovacs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230083743Abstract: An apparatus including an assembly associated with a downhole tool configured to thermally isolate a thermally sensitive component. Components of the assembly include an external isolating vessel; a passive thermal barrier encased in the external isolating vessel; at least one electronic component housed within the downhole tool for monitoring geothermal well properties; and at least one thermally sensitive electronics carrier package positioned within the passive thermal barrier comprising thermally sensitive electronic components. The passive thermal barrier ideally comprises an additively manufactured layered labyrinthine shell structure, a plurality of polarly phased centralizers between shell layers and minimal centralizing contact points on its exterior shell, to minimize known heat transfer modes associated with the external isolating vessel.Type: ApplicationFiled: September 10, 2022Publication date: March 16, 2023Applicant: SPARTAN DOWNHOLE, LLCInventors: JEFFREY JOHNSTON, JUSTIN SCRUGGS, WILLIAM AMEND, DANIEL HOYER, WILLIAM KOVACS, III, FEI TANG, CHRIS TAYLOR
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Patent number: 11512288Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.Type: GrantFiled: August 24, 2017Date of Patent: November 29, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Ernest William Kovacs, Anup Sood, Reginald Donovan Smith, Evelina Roxana Loghin, Padmaparna Chaudhuri, Vandana Keskar, Chrystal Mae Chadwick, Martin James Brown
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Publication number: 20220334110Abstract: Described are multi-functional beads and methods to capture rare cells directly from low-volume biological samples and perform both functional and genomic assays from those cells. This is accomplished using a multifunctional capture bead that allows co-localization of both the single cell capture element and the molecular assay components. When combined with a digital microfluidic platform this enables encoding and/or barcoding of specific single cells.Type: ApplicationFiled: June 30, 2022Publication date: October 20, 2022Inventors: Christopher Michael Puleo, Ernest William Kovacs, Brian Michael Davis
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Publication number: 20200181572Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.Type: ApplicationFiled: August 24, 2017Publication date: June 11, 2020Inventors: Ernest William Kovacs, Anup Sood, Reginald Donovan Smith, Evelina Roxana Loghin, Padmaparna Chaudhuri, Vandana Keskar, Chrystal Mae Chadwick, Martin James Brown
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Patent number: 10625242Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.Type: GrantFiled: October 5, 2016Date of Patent: April 21, 2020Assignee: General Electric CompanyInventors: Ernest William Kovacs, Frank John Mondello, Erik Leeming Kvam, Bing Li
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Patent number: 10450345Abstract: A method for purification of a target in a solution includes providing a target in a solution, the solution comprising one or more contaminants, providing a polymer conjugate in the solution, wherein the polymer conjugate is configured to specifically bind the target, incubating the solution at a first temperature to facilitate binding of the polymer conjugate to the target, providing an environmentally-responsive block copolymer in the solution, wherein the environmentally-responsive block copolymer comprises one or more of an ethylene oxide (EO), a propylene oxide (PO), or an EO/PO block copolymer, and heating the solution comprising the environmentally-responsive block copolymer and the polymer conjugate bound to the target at a second temperature to initiate a liquid-liquid phase separation, wherein the liquid-liquid phase separation produces an aqueous phase and a liquid polymer phase, and wherein the liquid polymer phase comprises the polymer conjugate bound to the target.Type: GrantFiled: June 9, 2017Date of Patent: October 22, 2019Assignee: General Electric CompanyInventors: Erik Leeming Kvam, Bruce Allan Hay, Ernest William Kovacs
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Patent number: 10294454Abstract: Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.Type: GrantFiled: August 24, 2016Date of Patent: May 21, 2019Assignee: General Electric CompanyInventors: Ernest William Kovacs, Anup Sood, Reginald Donovan Smith, Evelina Roxana Loghin, Padmaparna Chadhuri, Vandana Keskar, Chrystal Mae Chadwick, Martin James Brown
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Publication number: 20180354987Abstract: A method for purification of a target in a solution includes providing a target in a solution, the solution comprising one or more contaminants, providing a polymer conjugate in the solution, wherein the polymer conjugate is configured to specifically bind the target, incubating the solution at a first temperature to facilitate binding of the polymer conjugate to the target, providing an environmentally-responsive block copolymer in the solution, wherein the environmentally-responsive block copolymer comprises one or more of an ethylene oxide (EO), a propylene oxide (PO), or an EO/PO block copolymer, and heating the solution comprising the environmentally-responsive block copolymer and the polymer conjugate bound to the target at a second temperature to initiate a liquid-liquid phase separation, wherein the liquid-liquid phase separation produces an aqueous phase and a liquid polymer phase, and wherein the liquid polymer phase comprises the polymer conjugate bound to the target.Type: ApplicationFiled: June 9, 2017Publication date: December 13, 2018Inventors: Erik Leeming Kvam, Bruce Allan Hay, Ernest William Kovacs
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Publication number: 20180057791Abstract: Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.Type: ApplicationFiled: August 24, 2016Publication date: March 1, 2018Inventors: Ernest William Kovacs, Anup Sood, Reginald Donovan Smith, Evelina Roxana Loghin, Padmaparna Chadhuri, Vandana Keskar, Chrystal Mae Chadwick, Martin James Brown
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Publication number: 20170267716Abstract: Provided herein are aptamer-polymer conjugates which are responsive to environmental stimuli and are useful in selective purification of untagged target polypeptides.Type: ApplicationFiled: March 16, 2016Publication date: September 21, 2017Inventors: Anthony John Murray, Andrew David Pris, Erik Leeming Kvam, Nandini Nagraj, Eugene Pauling Boden, Ernest William Kovacs, Louisa Ruth Carr, Rui Chen, Tiberiu Mircea Siclovan, Kelly Scott Chichak
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Publication number: 20170205404Abstract: Described are multi-functional beads and methods to capture rare cells directly from low-volume biological samples and perform both functional and genomic assays from those cells. This is accomplished using a multifunctional capture bead that allows co-localization of both the single cell capture element and the molecular assay components. When combined with a digital microfluidic platform this enables encoding and/or barcoding of specific single cells.Type: ApplicationFiled: December 1, 2016Publication date: July 20, 2017Inventors: Christopher Michael Puleo, Ernest William Kovacs, Brian Michael Davis
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Patent number: 9600813Abstract: A point of sale computer system that allows a customer to select and consummate a sale himself. The system may include graphics storage media configured to store two- and three-dimensional graphics data relating to the sale, as well as business rules storage media, configured to store business rules that specify the graphics that should be displayed during the selection and consummation process based on input received from the customer. The technology allows a presentation to be made to the customer that is entertaining and that maintains the attention of the customer throughout the sale selection and consummation process.Type: GrantFiled: May 6, 2013Date of Patent: March 21, 2017Assignee: Tillster, Inc.Inventors: Paul Sidlo, William Kovacs, Philip J. Brock, John O'Keefe, Jonathan Humpherys, Andrew Whiddett, Simon Feltman, Amar Kurani
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Publication number: 20170021333Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.Type: ApplicationFiled: October 5, 2016Publication date: January 26, 2017Inventors: Ernest William Kovacs, Frank John Mondello, Erik Leeming Kvam, Bing LI
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Patent number: 9480966Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.Type: GrantFiled: April 25, 2014Date of Patent: November 1, 2016Assignee: General Electric CompanyInventors: Ernest William Kovacs, Erik Leeming Kvam, Bing Li, Frank John Mondello
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Publication number: 20140234942Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.Type: ApplicationFiled: April 25, 2014Publication date: August 21, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Ernest William Kovacs, Erik Leeming Kvam, Bing Li, Frank John Mondello
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Publication number: 20140057282Abstract: Methods and kits for binding and releasing biological targets, comprising, a binder having an environmentally reactive molecular switch that can switch between a high affinity state, to bind the target, to a low affinity state, to release the target. In one embodiment, the binder is a pre-existing chemical sequence, composition, or structural configuration but unknown or unspecified and still viable as a binder for attaching a molecular switch.Type: ApplicationFiled: November 5, 2013Publication date: February 27, 2014Applicant: General Electric CompanyInventors: Aaron Joseph Dulgar-Tulloch, Ernest William Kovacs, Evelina Roxana Loghin, Anup Sood
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Patent number: 8647829Abstract: Methods and kits for binding and releasing biological targets, comprising, a binder comprising an environmentally reactive molecular switch that can switch between a high affinity state, to bind the target, to a low affinity state, to release the target.Type: GrantFiled: July 7, 2009Date of Patent: February 11, 2014Assignee: General Electric CompanyInventors: Aaron Dulgar-Tulloch, Ernest William Kovacs, Evelina Roxana Loghin, Anup Sood
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Publication number: 20130246201Abstract: A point of sale computer system that allows a customer to select and consummate a sale himself. The system may include graphics storage media configured to store two- and three-dimensional graphics data relating to the sale, as well as business rules storage media, configured to store business rules that specify the graphics that should be displayed during the selection and consummation process based on input received from the customer. The technology allows a presentation to be made to the customer that is entertaining and that maintains the attention of the customer throughout the sale selection and consummation process.Type: ApplicationFiled: May 6, 2013Publication date: September 19, 2013Applicant: EMN8, Inc.Inventors: Paul Sidlo, William Kovacs, Philip J. Brock, John O'Keefe, Jonathan Humpherys, Andrew Whiddett, Simon Feltman, Amar Kurani
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Patent number: 8514548Abstract: Disclosed herein is a structural sheet includes an energy storage density that is greater than 10-mWh/ft2 and is capable of withstanding greater than 5-KPa stress under at least 5% strain.Type: GrantFiled: July 27, 2010Date of Patent: August 20, 2013Assignee: The Paper Battery Co.Inventors: Robert J. Miller, Trevor J. Simmons, Marsha M. Grade, Amber Brooks, Frank William Kovacs
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Patent number: 8487080Abstract: Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.Type: GrantFiled: February 22, 2011Date of Patent: July 16, 2013Assignee: General Electric CompanyInventors: Omayra Liz Padilla de Jesus, Faisal Ahmed Syud, Rong Zhang, Ernest William Kovacs