Abstract: Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

Abstract: Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

Abstract: Disclosed are synthetic nanocarrier compositions that comprise B cell antigen for desired antibody production and an off-target response attenuating polymeric coating as well as related methods.

Abstract: Disclosed is a large alloy forging, the forging having an alloy composition selected from one of a nickel base alloy, a cobalt-chromium-nickel base alloy, a nickel-cobalt base alloy and an iron-nickel-chromium-molybdenum alloy, the forging having a grain size of ASTM grain size 3 or finer, as measured by ASTM method E112 and having a tensile strength in the range of 135 to 175 KSI.

Abstract: Disclosed is a large alloy forging and method for making it. The forging having an alloy composition selected from one of a nickel base alloy, a cobalt-chromium-nickel base alloy, a nickel-cobalt base alloy and an iron-nickel-chromium-molybdenum alloy and having a grain size of ASTM grain size 4 or finer, as measured by ASTM method E112 and having a tensile strength in the range of 135 to 175 KSI. The process includes: (1) four upset forgings, (2) a rapid cooling after the final upset cooling, (3) a first and second upset forging with a reduction greater than 50%, (4) a third upset forging with a reduction greater than 25.%, and (5) a forging process with a fourth upset forging with a reduction greater than 50%.

Abstract: Disclosed is a method of producing a forged and rolled Al-Zn-Cu-Mg alloy plate product having improved fatigue properties in the long transverse direction. The method comprises providing a body of an Al-Zn-Cu-Mg alloy, working said body by a forging operation to reduce its thickness in a C direction by at least 30% and rolling or working the forged body to provide a forged and rolled plate product having improved fatigue properties in the long transverse direction.

Abstract: Disclosed is a process for forming a recrystallized forged product having low anisotropy or unrecrystallized forged products having high strength comprising providing a body of a lithium-containing aluminum base alloy comprised of 0.2 to 5 wt. % Li, 0.05 to 6 wt. % Mg, at least 2.45 wt. % Cu, 0.05 to 2 wt. % Zn, 0.5 wt. % max. Fe, 0.5 wt. % max. Si, at least one of the elements selected from the group consisting of Cr, V, Sc, Hf, Mn, Ag, In, Ti, Ni, Fe and Zr, with Cr, V, Ti and Zr in the range of 0.01 to 0.2 wt. %, Mn, Ni, Fe and Ag in the range of 0.01 to 1 wt. % and Hf, Sc and In in the range of 0.01 to 0.5 wt. %.