Abstract: Ester derivatives of N-substituted and N,N-disubstituted aminopropanoloxy flavones in which the aminopropanoloxy side chain is inserted at either the 5-, 6-, 7- or 8-position of the flavone nucleus, and N-substituted and N,N-disubstituted aminopropanoloxy flavones in which the aminopropanoloxy side chain is inserted at the 8-position of the flavone nucleus; useful as anti-dysrhythmic agents.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is H or NH.sub.2 ; R.sub.2 is C.sub.1-6 straight or branched chain alkyl; --CH.sub.2 OH; --(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --CH.sub.3 ; phenyl; or --(CH.sub.2).sub.p NH.sub.2 ;n is 1-3;m is 0-3; andp is 1-5;and the pharmaceutically acceptable acid addition salts of those compounds of basic character,have antisecretory activity.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is H or NH.sub.2 ;R.sub.2 is C.sub.1-6 straight or branched chain alkyl; --CH.sub.2 OH; --(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --CH.sub.3 ; phenyl; or --(CH.sub.2).sub.p NH.sub.2 ;n is 1-3;m is 0-3; andp is 1-5;and the pharmaceutically acceptable acid addition salts of those compounds of basic character, have antisecretory activity.

Abstract: Antiviral compositions and methods of inhibiting or inactivating viruses by administering to hosts an effective quantity of an active ingredient are disclosed herein. The active ingredients are those compounds having the formula ##STR1## wherein A is a straight or branched alkylene chain of from 1 to 6 carbon atoms and each Y is the group(A) ##STR2## wherein R.sup.1 and R.sup.2 are each individually selected from hydrogen, lower alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or(B) ##STR3## wherein n is a whole integer of 4, 5 or 6 and R.sup.3 is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl and can be attached to any one of the carbon atoms of the heterocyclic group; or(C) ##STR4## wherein X is oxygen or N--R.sup.4 and R.sup.

Abstract: The novel bis-basic ketones of fluorene and fluorenone of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##STR1## wherein Z is oxygen or H.sub.2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##STR2## wherein R.sup.1 and R.sup.2 are individually hydrogen, (lower)alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; orB. the group ##STR3## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R.sup.3 is hydrogen, (lower)alkyl of 1 to about 4 carbon atoms, phenyl, or benzyl and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##STR4## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or (lower)alkyl of from 1 to about 4 carbon atoms; orD.

Abstract: Novel 2,7-bis-basic derivatives of fluorene, 9-fluorenol and 9-fluorenone, their preparation and use for the prevention and inhibition of virus infections are disclosed.

Abstract: Novel 3,6-bis-basic alkanes of carbazole, their preparation and use for the prevention and inhibition of viral infections are disclosed.

Abstract: Novel triazolocycloalkylhydrothiadiazines and their preparation, which are useful as antisecretory agents, central nervous system stimulants, and central nervous system depressants, are disclosed.

Abstract: Novel triazolobenzocycloalkylthiadiazines, their preparation, and use as central nervous system antidepressants.

Abstract: Novel triazolocycloalkylthiadiazines, their preparation, and use as antisecretory agents and central nervous system depressants.

Abstract: Novel bis-basic esters and amides of dibenzothiophene of the formula ##SPC1##Wherein:A. each of R.sup.1 and R.sup.2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkylpiperazino, or morpholino;B. each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms;C. each Y is oxygen, or N--R wherein R is hydrogen or (lower)alkyl of 1 to 4 carbon atoms; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.

Abstract: There is disclosed a concentrated stable alkaline silica sol having a pH of from 7.0 to 10.0 consisting essentially of from 35% to 70% by weight of large, spherical, uniform, non-aggregated silica particles having a weight-average particle diameter of about 45 to about 100 millimicrons and water as the hydrophilic liquid carrier of said particles, said sol at a 50% silica concentration having a viscosity of less than 10 cps at 25.degree.C. and a specific conductance of less than 5000 micromhos/cm.

Abstract: The novel bis-basic ketones of carbazole of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1##Wherein Z is hydrogen or lower alkyl having from 1 to 4 carbon atoms; A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen or lower alkyl having from 1 to about 4 carbon atoms; orB. the group ##SPC2##Wherein n is a whole integer of 4 or 5, and R.sup.3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##SPC3##Wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms;Or a pharmaceutically acceptable acid addition salt of said base.These new compounds can be prepared by several different methods which are described.

Abstract: The novel bis-basic ethers of carbazole of the present invention have useful antiviral properties. These new compounds are represented by the formula ##SPC1##Wherein Z is hydrogen or lower alkyl having from 1 to 4 carbon atoms; and each X is ##EQU1## A. the group -A-N wherein each A is a straight or branched alkylene chain having from 2 to 6 carbon atoms; R and R.sup.1 are individually hydrogen or lower alkyl having from 1 to 6 carbon atoms; or each set of R and R.sup.1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino or piperidino; orB. the group ##SPC2##Wherein n is a whole integer from 0 to 2, m is 1 or 2, and R.sup.2 is hydrogen or lower alkyl having from 1 to 4 carbon atoms.This invention also includes pharmaceutically acceptable acid addition salts of the bases represented by Formula I. These new compounds may be prepared by several different methods which are described.

Abstract: Novel bis-basic esters and amides of carbazole of the formula ##SPC1##Wherein:A. each of R.sup.1 and R.sup.2 is hydrogen, (lower)alkyl, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower) alkylpiperazino, or morpholino;B. each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms;C. each Y is oxygen, or N--R wherein R is hydrogen, methyl or ethyl; andD. r.sup.3 is hydrogen or (lower) primary or secondary alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.