Abstract: A fluid administration device is provided which includes a catheter holder having a passage extending through it, a plastic cannula connected at the distal end of the passage, an elastomeric seal at the proximal end of the passage, and a fluid administration side port intermediate the ends of the passage. The device includes a needle holder having a needle cannula extending through the seal, passage, and into the catheter. When the needle holder is in its initial position, the seal is in a passage venting position so that a source of administration fluid can be connected to the side port and the device flushed of air. When the air is removed, the needle assembly is moved to an armed position forcing the seal into a compressed condition in the passage. After the catheter has been placed into the vein, the needle is withdrawn proximally from the catheter holder with the plug sealing the proximal end of the passage.