Abstract: The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A?-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid ? 1-42.

Abstract: The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid ? protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of generating ADDL-specific antibodies and methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.

Abstract: The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid &bgr; protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.

Abstract: The invention described in this disclosure involves a new composition of matter, amyloid beta-derived dementing ligands (ADDL's). ADDLs consist of amyloid &bgr; peptide assembled into soluble globular non-fibrillar oligomeric structures that are capable of activating specific cellular processes. The invention further encompasses methods for assaying the formation, presence, receptor protein binding and cellular activities of ADDLs. The invention further encompasses assay methods and inhibitor molecules for cellular signaling molecules activated by ADDLs. Also described are molecules that block proteins that promote the formation of ADDLs.

Abstract: A composition which is includes discrete particles of a highly cross-linked macroporous hydrophobic polymer. The particles are of a first predetermined average diameter, and the polymer particles have entrapped therein and dispersed uniformly throughout an active ingredient. The composition also includes a coacervating agent mixed with the polymer particles in an amount sufficient to cause the polymer particles to collect forming dense clusters of coacervated particles of a second predetermined average diameter, the second predetermined average diameter being substantially in excess of the first predetermined average diameter.

Abstract: A method of recovering oil floating on a water surface which has been contaminated with the oil by distributing upon the contaminated surface discrete particles of a hydrophobic macroporous highly crosslinked polymer. The particles are allowed to adsorb and to become laden with the oil. The oil laden particles are recovered from the water surface, and the oil from the oil laden particles is removed by applying compressive forces to the oil laden particles. Particles which are substantially free of the oil are recirculated and re-distributed upon the contaminated surface, and this sequence of steps is repeated until substantially all of the oil has been recovered.

Abstract: A precipitation polymerization process for the production of a macroporous cross-linked copolymer in which there is added to a reactor equipped with a stirrer, at least one monounsaturated monomer and at least one polyunsaturated monomer, dissolving an inorganic polymerization reaction initiator in a homogeneous minimum-boiling binary azeotrope including a solvent and water, and conducting the polymerization in the azeotrope.

Abstract: This invention relates to improved hair products which contain dialkyl diallyl ammonium chloride/acrylic acid-type polymers. These polymers provide exceptional conditioning properties to hair products such as shampoos, conditioners, rinses, bleaches, hair dyes and hair sprays.

Abstract: This invention relates to improved personal skin care products which contain dimethyl diallyl ammonium chloride/acrylic acid-type polymers. These polymers provide exceptional feel to skin when personal skin care products containing them, such as hand and face lotions, soaps or creams, suntan lotions, bubble baths, shaving creams, antiperspirants, and deodorants, are used.

Abstract: The invention relates to stable deodorant compositions comprising at least one antimicrobial agent and poly-dimethyldialkyl ammonium chloride-acrylamide copolymers or dimethyldialkyl ammonium chloride cationic polymer which serve to enhance the residual efficacy of said agent on a surface.