Patents by Inventor William L. Olbricht
William L. Olbricht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10537725Abstract: A method for convection-enhanced delivery (CED) of compounds and an apparatus for use with the method are provided. The apparatus, an ultrasound transducer cannula assembly (TCA) apparatus, can be used for the delivery of a compound to a target in the body such as a cells, tissue or organ in a healthy or diseased state. The ultrasound TCA apparatus comprises a transducer cannula assembly (TCA) and an ultrasound system to enhance penetration of molecules in the target. The ultrasound system may be portable and pocket-sized. The inclusion of ultrasound in the apparatus improves the distribution volume of material four to six times over a convection-enhanced delivery system without ultrasound. Since the targeting can be more focused, less compound is needed, thus lowering the potential for harmful effects to the host and host cells.Type: GrantFiled: March 4, 2011Date of Patent: January 21, 2020Assignee: CORNELL UNIVERSITYInventors: George K. Lewis, Jr., William L. Olbricht
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Patent number: 10092271Abstract: There is set forth herein a uterine probe having one or more transducer for detecting a uterine parameter. The one or more parameter can be a fetal heart rate. The one or more parameter can be uterine contraction. In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a fetal heart rate (FHR). In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a uterine contraction. The one or more transducer can be of a common technology or can be of different technology. In one embodiment a uterine probe can include one or more transducer that is operative to be driven in different signaling configurations. A first signaling configuration can be a signaling configuration for detection of a fetal heart rate. A second signaling configuration can be a signaling configuration for detection of uterine contraction.Type: GrantFiled: April 13, 2012Date of Patent: October 9, 2018Assignee: CORNELL UNIVERSITYInventors: George K. Lewis, Jr., William L. Olbricht, Steven Gelber, George K. Lewis, Sr.
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Patent number: 9844585Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue.Type: GrantFiled: June 25, 2014Date of Patent: December 19, 2017Assignees: YALE UNIVERSITY, CORNELL UNIVERSITYInventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Matthews, W. Mark Saltzman, Andrew Sawyer
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Publication number: 20140371712Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue.Type: ApplicationFiled: June 25, 2014Publication date: December 18, 2014Applicants: YALE UNIVERSITY, CORNELL UNIVERSITYInventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Matthews, W. Mark Saltzman, Andrew Sawyer
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Publication number: 20140350397Abstract: There is set forth herein a uterine probe having one or more transducer for detecting a uterine parameter. The one or more parameter can be a fetal heart rate. The one or more parameter can be uterine contraction. In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a fetal heart rate (FHR). In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a uterine contraction. The one or more transducer can be of a common technology or can be of different technology. In one embodiment a uterine probe can include one or more transducer that is operative to be driven in different signaling configurations. A first signaling configuration can be a signaling configuration for detection of a fetal heart rate. A second signaling configuration can be a signaling configuration for detection of uterine contraction.Type: ApplicationFiled: April 13, 2012Publication date: November 27, 2014Applicant: CORNELL UNIVERSITYInventors: George K. Lewis, JR., William L. Olbricht, Steven Gelber, George K. Lewis, SR.
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Patent number: 8790317Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (eg, a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device.Type: GrantFiled: February 12, 2008Date of Patent: July 29, 2014Assignees: Cornell University, Yale UniversityInventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Mattews, W. Mark Saltzman, Andrew Sawyer
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Publication number: 20130046230Abstract: A method for convection-enhanced delivery (CED) of compounds and an apparatus for use with the method are provided. The apparatus, an ultrasound transducer cannula assembly (TCA) apparatus, can be used for the delivery of a compound to a target in the body such as a cells, tissue or organ in a healthy or diseased state. The ultrasound TCA apparatus comprises a transducer cannula assembly (TCA) and an ultrasound system to enhance penetration of molecules in the target. The ultrasound system may be portable and pocket-sized. The inclusion of ultrasound in the apparatus improves the distribution volume of material four to six times over a convection-enhanced delivery system without ultrasound. Since the targeting can be more focused, less compound is needed, thus lowering the potential for harmful effects to the host and host cells.Type: ApplicationFiled: March 4, 2011Publication date: February 21, 2013Applicant: CORNELL UNIVERSITYInventors: George K. Lewis, JR., William L. Olbricht
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Publication number: 20100098767Abstract: An embodiment of the invention is directed to a microfabr?cated, silicon-based, Convection Enhanced Delivery (CED) device The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e g, a drug) to the microfabricated device The device may have multiple channels disposed side by side or in different surfaces of the deviceType: ApplicationFiled: February 12, 2008Publication date: April 22, 2010Inventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Mattews, Mark W. Saltzman, Andrew Sawyer