Patents by Inventor William Lawrance
William Lawrance has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240010702Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: ApplicationFiled: August 1, 2023Publication date: January 11, 2024Inventors: Nicholas Tribble, Eleanor Bagg, William Lawrance
-
Patent number: 11753456Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: GrantFiled: October 14, 2021Date of Patent: September 12, 2023Assignee: Adaptimmune LimitedInventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Patent number: 11725040Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: GrantFiled: October 14, 2021Date of Patent: August 15, 2023Assignee: Adaptimmune LimitedInventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Patent number: 11572400Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: GrantFiled: August 17, 2022Date of Patent: February 7, 2023Assignee: Adaptimmune LimitedInventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Publication number: 20230028573Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: ApplicationFiled: August 17, 2022Publication date: January 26, 2023Inventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Publication number: 20220127327Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: ApplicationFiled: January 12, 2022Publication date: April 28, 2022Inventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Patent number: 11286289Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: GrantFiled: October 8, 2018Date of Patent: March 29, 2022Assignee: ADAPTIMMUNE LIMITEDInventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Publication number: 20220031753Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: ApplicationFiled: October 14, 2021Publication date: February 3, 2022Inventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Publication number: 20220025013Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: ApplicationFiled: October 14, 2021Publication date: January 27, 2022Inventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Publication number: 20190144521Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: ApplicationFiled: October 8, 2018Publication date: May 16, 2019Inventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Publication number: 20190135892Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: ApplicationFiled: October 8, 2018Publication date: May 9, 2019Inventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Publication number: 20190127436Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the MAGE-A4 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.Type: ApplicationFiled: October 8, 2018Publication date: May 2, 2019Inventors: Nicholas Tribble, William Lawrance, Eleanor Bagg
-
Patent number: 7082551Abstract: Bulk data is read or written by an application on a first computer system to a file on a second heterogeneous computer system. Alternatively it is read or written as bulk data directly between applications on these heterogeneous systems. Jobs or tasks are started from one system to execute on a second heterogeneous system. Results are then returned to the first system. Checkpointing and later restarting is also initiated from a first system for execution on the second heterogeneous system.Type: GrantFiled: June 29, 2001Date of Patent: July 25, 2006Assignee: Bull HN Information Systems Inc.Inventors: William Lawrance, Howard Hagan, David S. Edwards
-
Patent number: 7024467Abstract: Bulk data is read or written by an application on a first computer system to a file on a second heterogeneous computer system. Alternatively it is read or written as bulk data directly between applications on these heterogeneous systems. Jobs or tasks are started from one system to execute on a second heterogeneous system. Results are then returned to the first system. Checkpointing and later restarting is also initiated from a first system for execution on the second heterogeneous system.Type: GrantFiled: June 29, 2001Date of Patent: April 4, 2006Assignee: Bull HN Information Systems Inc.Inventors: Kenneth R. Rosensteel, Jr., William Lawrance, Howard Hagan
-
Patent number: 6615217Abstract: Bulk data is read or written by an application on a first computer system to a file on a second heterogeneous computer system. Alternatively it is read or written as bulk data directly between applications on these heterogeneous systems. Jobs or tasks are started from one system to execute on a second heterogeneous system. Results are then returned to the first system. Checkpointing and later restarting is also initiated from a first system for execution on the second heterogeneous system.Type: GrantFiled: June 29, 2001Date of Patent: September 2, 2003Assignee: Bull HN Information Systems Inc.Inventors: Kenneth R. Rosensteel, Jr., Ken Allen, William Lawrance
-
Publication number: 20030140041Abstract: Bulk data is read or written by an application on a first computer system to a file on a second heterogeneous computer system. Alternatively it is read or written as bulk data directly between applications on these heterogeneous systems. Jobs or tasks are started from one system to execute on a second heterogeneous system. Results are then returned to the first system. Checkpointing and later restarting is also initiated from a first system for execution on the second heterogeneous system.Type: ApplicationFiled: June 29, 2001Publication date: July 24, 2003Applicant: Bull HN Information Systems IncInventors: Kenneth R. Rosensteel, Ken Allen, William Lawrance
-
Publication number: 20030140220Abstract: Bulk data is read or written by an application on a first computer system to a file on a second heterogeneous computer system. Alternatively it is read or written as bulk data directly between applications on these heterogeneous systems. Jobs or tasks are started from one system to execute on a second heterogeneous system. Results are then returned to the first system. Checkpointing and later restarting is also initiated from a first system for execution on the second heterogeneous system.Type: ApplicationFiled: June 29, 2001Publication date: July 24, 2003Applicant: Bull HN Information Systems Inc.Inventors: William Lawrance, Ken Allen, Kenneth R. Rosensteel
-
Publication number: 20030140170Abstract: Bulk data is read or written by an application on a first computer system to a file on a second heterogeneous computer system. Alternatively it is read or written as bulk data directly between applications on these heterogeneous systems. Jobs or tasks are started from one system to execute on a second heterogeneous system. Results are then returned to the first system. Checkpointing and later restarting is also initiated from a first system for execution on the second heterogeneous system.Type: ApplicationFiled: June 29, 2001Publication date: July 24, 2003Applicant: Bull HN Information Systems Inc.Inventors: Kenneth R. Rosensteel, William Lawrance, Scott Sygrove, Lynn Walker
-
Publication number: 20030140272Abstract: Bulk data is read or written by an application on a first computer system to a file on a second heterogeneous computer system. Alternatively it is read or written as bulk data directly between applications on these heterogeneous systems. Jobs or tasks are started from one system to execute on a second heterogeneous system. Results are then returned to the first system. Checkpointing and later restarting is also initiated from a first system for execution on the second heterogeneous system.Type: ApplicationFiled: June 29, 2001Publication date: July 24, 2003Applicant: Bull NH Information Systens Inc,Inventors: William Lawrance, Howard Hagan, David S. Edwards
-
Publication number: 20030131109Abstract: Bulk data is read or written by an application on a first computer system to a file on a second heterogeneous computer system. Alternatively it is read or written as bulk data directly between applications on these heterogeneous systems. Jobs or tasks are started from one system to execute on a second heterogeneous system. Results are then returned to the first system. Checkpointing and later restarting is also initiated from a first system for execution on the second heterogeneous system.Type: ApplicationFiled: June 29, 2001Publication date: July 10, 2003Applicant: Bull HN Information Systems Inc.Inventors: Kenneth R. Rosensteel, William Lawrance, Howard Hagan
