Patents by Inventor William Leo Murphy

William Leo Murphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN PLURIPOTENT STEM CELL-DERIVED BRAIN ORGANOIDS FOR CANCER MODELING AND DRUG SCREENING
    Publication number: 20200318075
    Abstract: The present invention relates to substantially planar vascularized brain cancer organoid and methods of using such vascularized brain cancer organoids in anti-cancer drug discovery screen. In particular, provided herein are methods of producing and using complex, highly uniform vascularized brain cancer organoids that comprise physiologically relevant human cells and have the high degree of sample uniformity and reproducibility required for use in high-throughput screening applications.
    Type: Application
    Filed: March 26, 2020
    Publication date: October 8, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Elizabeth Anne Aisenbrey, William Leo Murphy, Elizabeth Emma Torr, Victoria Harms, Gaurav Kaushik
  • HYDROGEL COMPOSITIONS FOR USE IN NEURAL CELL EXPANSION AND DIFFERENTIATION
    Publication number: 20200017823
    Abstract: Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiation of various neuronal cells. The hydrogel compositions can further be used in toxicity screening assays for neurotoxicants.
    Type: Application
    Filed: July 12, 2019
    Publication date: January 16, 2020
    Inventors: William Leo Murphy, William Timothy Daly, Jonathan Lloyd Evans, Elizabeth Anne Aisenbrey, Elizabeth Emma Torr
  • Hydrogel microspheres containing peptide ligands for growth factor regulation in blood products
    Patent number: 10183079
    Abstract: Vascular endothelial growth factor VEGF-sequestering hydrogel microspheres that have been prepared to selectively bind VEGF from blood products are disclosed herein. In one particular embodiment, the microspheres bind VEGF as part of an intra-operative process such that the growth factor can be removed from the blood products before the products are used in a clinical procedure.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: January 22, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David Belair, Ngoc Nhi Le, Michael W. Toepke, Nicholas Impellitteri, Connie Sue Chamberlain, William Leo Murphy
  • HYDROGEL MICROSPHERES CONTAINING PEPTIDE LIGANDS FOR GROWTH FACTOR REGULATION IN BLOOD PRODUCTS
    Publication number: 20170266318
    Abstract: Vascular endothelial growth factor VEGF-sequestering hydrogel microspheres that have been prepared to selectively bind VEGF from blood products are disclosed herein. In one particular embodiment, the microspheres bind VEGF as part of an intra-operative process such that the growth factor can be removed from the blood products before the products are used in a clinical procedure.
    Type: Application
    Filed: March 18, 2016
    Publication date: September 21, 2017
    Inventors: David Belair, Ngoc Nhi Le, Michael W. Toepke, Nicholas Impellitteri, Connie Sue Chamberlain, William Leo Murphy
  • Spatial control of signal transduction
    Patent number: 8389009
    Abstract: Substrates and matrices for spatial control of signal transduction by a biologically active, soluble molecule that transduces a signal to a cell responsive to the molecule are disclosed.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: March 5, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: William Leo Murphy, Gregory Allan Hudalla