Patents by Inventor William Link
William Link has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132939Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: ApplicationFiled: December 12, 2023Publication date: April 25, 2024Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20240093271Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: ApplicationFiled: November 20, 2023Publication date: March 21, 2024Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20200222733Abstract: An example mitigation device includes a spine having a first support and a second support, the first support and the second support are substantially rectangular with semicircular ends. A plurality of linear tines sandwiched between the first support and the second support and extending in two opposite directions from the spine. A socket on the spine to receive a handle. In an example, each of the tines extend about one-third the length of the tine on a first side of the spine, and each of the tines extend about two-thirds the length of the tine on a second side of the spine. In an example, the tines are substantially perpendicular to the socket and the handle and configured to support the handle in a substantially upright position perpendicular to the ground when the tines are laid substantially flat on the ground.Type: ApplicationFiled: January 6, 2020Publication date: July 16, 2020Inventor: William Link
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Patent number: 10493448Abstract: In one arrangement, a cartridge includes a cartridge body defining a holding compartment, first and second fractioning compartments, and a number of flow channels formed within the cartridge body. A predetermined quantity of fluid can be held in the holding compartment when the cartridge body is held in a first orientation, and can be poured from the holding compartment to the first fractioning compartment by rotating the cartridge body about a predefined rotation axis to a second orientation, spilling the fluid from the holding compartment to the first fractioning compartment through one of the flow channels. The first fractioning compartment is such that when the cartridge body is in the second orientation, not all of the fluid can be contained in the first fractioning compartment, and fluid that overflows the first fractioning compartment flows through a second flow channel to the second fractioning compartment.Type: GrantFiled: March 8, 2016Date of Patent: December 3, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Glenn Price, Chris Charlton, William Link, Robert Alan Iovanni, Anthony F. Prestigiacomo
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Patent number: 9694360Abstract: A system for fluid manipulation includes a composite wafer and a movable compression device. The composite wafer includes a flexible layer and a substantially rigid layer adhered to the flexible layer. The flexible layer defines one or more recesses that are covered by the substantially rigid layer to form one or more reservoirs and one or more fluid channels among the one or more reservoirs. The movable compression device contacts the flexible layer and is configured to progressively compress the flexible layer such that when the movable compression device traverses the flexible layer, fluid is forced through the one or more fluid channels and the one or more reservoirs in a sequence determined by the layout of the one or more fluid channels and the one or more reservoirs. Certain reservoirs may be pre-loaded with fluids and reagents for performing a specified medical test.Type: GrantFiled: September 29, 2014Date of Patent: July 4, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Glenn Price, Luis Ortiz Hernandez, Robert Iovanni, William Link
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Publication number: 20160266099Abstract: In one arrangement, a cartridge includes a cartridge body defining a holding compartment, first and second fractioning compartments, and a number of flow channels formed within the cartridge body. A predetermined quantity of fluid can be held in the holding compartment when the cartridge body is held in a first orientation, and can be poured from the holding compartment to the first fractioning compartment by rotating the cartridge body about a predefined rotation axis to a second orientation, spilling the fluid from the holding compartment to the first fractioning compartment through one of the flow channels. The first fractioning compartment is such that when the cartridge body is in the second orientation, not all of the fluid can be contained in the first fractioning compartment, and fluid that overflows the first fractioning compartment flows through a second flow channel to the second fractioning compartment.Type: ApplicationFiled: March 8, 2016Publication date: September 15, 2016Applicant: Bio-Rad Laboratories, Inc.Inventors: Glenn Price, Chris Charlton, William Link, Robert Alan Iovanni, Anthony F. Prestigiacomo
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Publication number: 20160089670Abstract: A system for fluid manipulation includes a composite wafer and a movable compression device. The composite wafer includes a flexible layer and a substantially rigid layer adhered to the flexible layer. The flexible layer defines one or more recesses that are covered by the substantially rigid layer to form one or more reservoirs and one or more fluid channels among the one or more reservoirs. The movable compression device contacts the flexible layer and is configured to progressively compress the flexible layer such that when the movable compression device traverses the flexible layer, fluid is forced through the one or more fluid channels and the one or more reservoirs in a sequence determined by the layout of the one or more fluid channels and the one or more reservoirs. Certain reservoirs may be pre-loaded with fluids and reagents for performing a specified medical test.Type: ApplicationFiled: September 29, 2014Publication date: March 31, 2016Inventors: Glenn Price, Luis Ortiz Hernandez, Robert Iovanni, William Link
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Publication number: 20140322073Abstract: A hand rail sanitizing system for sanitizing a hand rail of an escalator stairway from germs and bacteria on the hand rail is provided. The hand rail has a top wall, a bottom wall, and a pair of side walls. The hand rail sanitizing system comprises a container having a top wall and a bottom wall with the container positioned nearingly adjacent the hand rail. A UV-light emitting diode (LED) bulb is encased within the container. As the hand rail continuously passes by the container, the LED bulb irradiates through the bottom wall of the container toward the top wall of the hand rail.Type: ApplicationFiled: April 24, 2014Publication date: October 30, 2014Inventors: Kurt Link, William Link