Patents by Inventor William LOSTAL

William LOSTAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL POLYNUCLEOTIDES ENCODING A HUMAN FKRP PROTEIN
    Publication number: 20230321277
    Abstract: The present invention concerns synthetic polynucleotides encoding a human fukutin-related protein (FKRP) wherein the synthetic polynucleotides contain at least a mutation avoiding supplementary transcript(s) generated from frameshift start codon(s). The synthetic polynucleotides are useful, especially for treating a pathology linked to a FKRP deficiency or induced by a defect in ?-dystroglycan (?-DG) glycosylation, such as LGMD2I.
    Type: Application
    Filed: March 2, 2023
    Publication date: October 12, 2023
    Inventors: Isabelle RICHARD, Evelyne GICQUEL-ZOUIDA, William LOSTAL
  • A NOVEL MUSCLE-SPECIFIC PROMOTER
    Publication number: 20230277686
    Abstract: The present invention concerns a novel short promoter characterized by a high activity in the skeletal muscles and a low activity in the heart. It then constitutes a valuable candidate especially for driving the expression of transgenes encoding proteins useful for the treatment of muscular dystrophies.
    Type: Application
    Filed: July 9, 2021
    Publication date: September 7, 2023
    Inventors: William LOSTAL, Isabelle RICHARD
  • Synthetic polynucleotides encoding a human FKRP protein
    Patent number: 11596698
    Abstract: The present invention concerns synthetic polynucleotides encoding a human fukutin-related protein (FKRP) wherein the synthetic polynucleotides contain at least a mutation avoiding supplementary transcript(s) generated from frameshift start codon(s). The synthetic polynucleotides are useful, especially for treating a pathology linked to a FKRP deficiency or induced by a defect in ?-dystroglycan (?-DG) glycosylation, such as LGMD2I.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: March 7, 2023
    Assignees: GENETHON, UNIVERSITE D'EVRY-VAL-D'ESSONNE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Isabelle Richard, Evelyne Gicquel-Zouida, William Lostal
  • PRODUCTION OF LARGE-SIZED QUASIDYSTROPHINS USING OVERLAPPING AAV VECTORS
    Publication number: 20220204574
    Abstract: The present invention concerns a quasidystrophin (QD) having the structure CH1CH2H1R1R2R3H2R8R9 in its N-terminal part and advantageously further comprising the R16 and R17 rod domains, as well as the dual AAV vector system which allows producing it.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 30, 2022
    Inventors: Isabelle RICHARD, William LOSTAL