Abstract: A computer-implemented bone-implant system evaluation method for application of mesh-free analysis of a bone-implant system for evaluation of performance of a bone-implant system for an implant implanted within the bone structure at an anatomical site, said method comprising (i) receiving a set of bone structure data set, wherein set of bone structure data includes data indicative of the bone structure at an anatomical site; (ii) inputting an implant data set and inputting the position of the implant data set, wherein the implant is selected based upon the biomechanical requirements for the anatomical site and the position and of the implant data set is indicative of the position of the implant with respect to the anatomical site, wherein implant data set includes data representative of the geometry and materials properties of the implant; (iii) creating a bone-implant model, wherein said bone implant-model includes a mesh-free model of trabecular bone at the anatomical site wherein the bone-implant model is

Abstract: Provided are methods for dynamic orchestration of modems in an autonomous vehicle, which can include an SoC determining performance parameters from a plurality of modems and controlling communication of data between ECUs and the modems. Some methods described also include an SoC acting as a forwarding daemon, communicating with a switch, and or providing configuration data. Systems and computer program products are also provided.

Abstract: Compositions comprising and methods for the treatment of cancer using a NeoTCR based cell therapy with a modified TGF?RII expression.

Abstract: A computer-implemented bone-implant system evaluation method for application of mesh-free analysis of a bone-implant system for evaluation of performance of a bone-implant system for an implant implanted within the bone structure at an anatomical site, said method comprising (i) receiving a set of bone structure data set, wherein set of bone structure data includes data indicative of the bone structure at an anatomical site; (ii) inputting an implant data set and inputting the position of the implant data set, wherein the implant is selected based upon the biomechanical requirements for the anatomical site and the position and of the implant data set is indicative of the position of the implant with respect to the anatomical site, wherein implant data set includes data representative of the geometry and materials properties of the implant; (iii) creating a bone-implant model, wherein said bone implant-model includes a mesh-free model of trabecular bone at the anatomical site wherein the bone-implant model is

Abstract: Compositions comprising and methods for the treatment of cancer using a NeoTCR based cell therapy with a secondary Payload in an expression construct.

Abstract: An acoustic resonator has a piezoelectric plate having first and second surfaces, the second surface facing a substrate, and a diaphragm of the piezoelectric plate spanning a cavity. A conductor pattern is formed on at least one of the first and second surfaces and has an interdigital transducer (IDT) having interleaved fingers on the diaphragm portion of the piezoelectric plate. At least one of a pitch of the interleaved IDT fingers or a mark of the interleaved IDT fingers varies over an area of the IDT to compensate for process-induced distortion of the diaphragm portion of the piezoelectric plate.

Abstract: An acoustic resonator device includes a substrate having a surface; an 82Y-cut lithium niobate piezoelectric plate attached to the surface of the substrate except for a portion of the piezoelectric plate forming a diaphragm that spans a cavity in an intermediate dielectric layer of the substrate; an interdigital transducer (IDT) at the piezoelectric plate such that interleaved fingers of the IDT are at the diaphragm; and a plurality of stripes of a dielectric material extending over ends of the interleaved fingers and portions of gaps between the ends of the interleaved fingers and opposing busbars of the IDT.

Abstract: Provided are methods for providing escalation based responses, which can include obtaining sensor data and determining whether the data satisfies at least one of one or more criteria. Some methods described also include determining a violation parameter and/or a response indicative of an escalation of a policy violation. Systems and computer program products are also provided.

Abstract: Devices and methods for the removal of bone implant tips from within a bony structure in a body. The device or method includes a shaft with an internal grasping feature capable of being inserted while remaining in an un-expanded, un-deployed state. This permits a surgeon or operator to insert the device while in a small profile state, avoiding or reducing damage to adjacent bone tissue during insertion. Upon insertion of the shaft to the proper position within a patient's bone, the grasping feature may then be expanded or deployed from the distal end of the shaft by a surgeon or operator using an actuator in a handle attached to the proximal end of the shaft. Following deployment, the grasping feature may be used to manipulate and/or remove a bone implant tip from a patient's bone tissue. Embodiments of the grasping feature include one or more hooks, wires, articulating fingers, and/or net-based designs formed of metal, polymer, composite, or a combination thereof.

Abstract: Disclosed herein are methods for identifying the effects, including off target effect, of genomic modification of primary cells. These methods are performed with high accuracy suitable for validating therapeutic T-cell engineering approaches.

Abstract: A computer-implemented bone-implant system evaluation method for application of mesh-free analysis of a bone-implant system for evaluation of performance of a bone-implant system for an implant implanted within the bone structure at an anatomical site, said method comprising (i) receiving a set of bone structure data set, wherein set of bone structure data includes data indicative of the bone structure at an anatomical site; (ii) inputting an implant data set and inputting the position of the implant data set, wherein the implant is selected based upon the biomechanical requirements for the anatomical site and the position and of the implant data set is indicative of the position of the implant with respect to the anatomical site, wherein implant data set includes data representative of the geometry and materials properties of the implant; (iii) creating a bone-implant model, wherein said bone implant-model includes a mesh-free model of trabecular bone at the anatomical site wherein the bone-implant model is

Abstract: Devices and methods for the removal of bone implant tips from within a bony structure in a body. The device or method includes a shaft with an internal grasping feature capable of being inserted while remaining in an un-expanded, un-deployed state. This permits a surgeon or operator to insert the device while in a small profile state, avoiding or reducing damage to adjacent bone tissue during insertion. Upon insertion of the shaft to the proper position within a patient's bone, the grasping feature may then be expanded or deployed from the distal end of the shaft by a surgeon or operator using an actuator in a handle attached to the proximal end of the shaft. Following deployment, the grasping feature may be used to manipulate and/or remove a bone implant tip from a patient's bone tissue. Embodiments of the grasping feature include one or more hooks, wires, articulating fingers, and/or net-based designs formed of metal, polymer, composite, or a combination thereof.

Abstract: A cushion for inserting in the legwell between individual seats in rows of seats, for example in a vehicle, is disclosed. The top of the cushion can act as a surface for a user to lie down. The cushion can be inflatable and can be deflated for easy transport. The cushion can have multiple reservoirs so the internal pressure can be separately adjusted for the base and for the mattress of the cushion, similar to a box spring and a mattress in a common bed.

Abstract: A cushion for inserting in the legwell between individual seats in rows of seats, for example in a vehicle, is disclosed. The top of the cushion can act as a surface for a user to lie down. The cushion can be inflatable and can be deflated for easy transport. The cushion can have multiple reservoirs so the internal pressure can be separately adjusted for the base and for the mattress of the cushion, similar to a box spring and a mattress in a common bed.

Abstract: A cushion for inserting in the legwell between individual seats in rows of seats, for example in a vehicle, is disclosed. The top of the cushion can act as a surface for a user to lie down. The cushion can be inflatable and can be deflated for easy transport. The cushion can have multiple reservoirs so the internal pressure can be separately adjusted for the base and for the mattress of the cushion, similar to a box spring and a mattress in a common bed.

Abstract: Compositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and combinations thereof and one or more anions. Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof. The particles can be formulated for enteral or parenteral administration by incorporating the particles into a pharmaceutically carrier. The compositions can further contain one or more active agents useful for bone diseases or disorders, such as vitamin D, growth factors, and combinations thereof. The compositions can be used to treat or prevent one or more bone diseases or disorders of the bone, such as osteoporosis. Alternatively, the particles can be coated onto a substrate, such as the surface of an implant.

Abstract: The present invention discloses a data scanning system and a method thereof for a server. The method includes steps of defining an auditing period, scanning an accessed data in a default scanning mode from the server by a user, obtaining a credit data of the user, and executing a rearranging process for resetting a reset scanning mode for the user according to the credit data when the auditing period is expired, thereby the default scanning mode being adjustable according to the credit data of the user.

Abstract: The present invention discloses a data scanning system and a method thereof for a server. The method includes steps of defining an auditing period, scanning an accessed data in a default scanning mode from the server by a user, obtaining a credit data of the user, and executing a rearranging process for resetting a reset scanning mode for the user according to the credit data when the auditing period is expired, thereby the default scanning mode being adjustable according to the credit data of the user.

Abstract: A mechanism to connect the supporting portions of orthopaedic implants such as in the head, spine, upper limb and lower limb and thereby prevent loosening and fretting at the implant interface of an orthopaedic implant construct has been developed based on shape memory effect and super-elasticity of shape memory materials such as nickel-titanium (nitinol or NiTi) shape-memory-alloy, without the use of typical threaded fastening technique. Advantages are conferred by making the entire device, not just connecting pieces, out of shape memory alloy and having shape memory effect and super-elasticity. Heating the memory head of the device will compress the connection portion without the use of an auxiliary device (e.g. coupling member) so that the connection portion can be completely clamped down by the memory head.

Abstract: The present invention relates generally to a shape memory and/or super-elastic material, such as a nickel titanium alloy. Additionally or alternatively, the present invention relates to a super-elastic or pseudo-elastic material that has an initial transition temperature Af above a body temperature. The shape memory material can have a super-elasticity or pseudo-elasticity property at a temperature below the initial transition temperature Af of the material. For example, the shape memory material can have its workable temperature for producing super-elasticity or pseudo-elasticity of about 0° C. to 15° C. below the initial transition temperature Af. The shape memory material can be malleable at a room temperature, and become super-elastic or pseudo-elastic at a body temperature. In addition, the present invention relates to a method of making a shape memory or a super-elastic material.