Abstract: A needle receptacle that includes a sheath with a cradle portion and attached barrel end and may include top and end covers as a syringe and needle housing. The cradle portion is open along its top portion and includes parallel spaced apart finger protective flanges at opposite sides of a finger grasping portion formed therearound. The barrel end is tapered into a needle receiving portion and includes a flared connection between the cradle and the barrel end to serve as a guide for needles inserted into the barrel, which barrel also includes a detent extending radially therein for preventing needle turning.