Patents by Inventor William M. Kelley

William M. Kelley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid adenovirus-AAV virus and methods of use thereof
    Patent number: 6387368
    Abstract: The present invention provides a hybrid vector construct which comprises a portion of an adenovirus, 5′ and 3′ ITR sequences from an AAV, and a selected transgene. Other hybrid vectors form a polycation conjugate and incorporate an AAV rep gene in a single particle. These hybrid virus vectors are characterized by high titer transgene delivery to a host cell and the ability to stably integrate the transgene into the host cell chromosome. Also disclosed is the use of the hybrid vectors to produce large quantities of recombinant AAV.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: May 14, 2002
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, William M. Kelley, Krishna J. Fisher
  • Hybrid adenovirus-AAV virus and methods of use thereof
    Patent number: 6251677
    Abstract: The present invention provides a hybrid vector construct which comprises a portion of an adenovirus, 5′ and 3′ ITR sequences from an AAV, and a selected transgene. Also provided is a hybrid virus linked via a polycation conjugate to an AAV rep gene to form a single particle. These trans-infection particles are characterized by high titer transgene delivery to a host cell and the ability to stably integrate the transgene into the host cell chromosome. Also disclosed is the use of the hybrid vectors and viruses to produce large quantities of recombinant AAV.
    Type: Grant
    Filed: February 8, 1999
    Date of Patent: June 26, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, William M. Kelley, Krishna J. Fisher
  • Hybrid adenovirus-AAV virus and methods of use thereof
    Patent number: 5871982
    Abstract: The present invention provides a hybrid vector construct which comprises a portion of an adenovirus, 5' and 3'ITR sequences from an AAV, and a selected transgene. Also provided is a hybrid virus linked via a polycation conjugate to an AAV rep gene to form a single particle. These trans-infection particles are characterized by high titer transgene delivery to a host cell and the ability to stably integrate the transgene into the host cell chromosome. Also disclosed is the use of the hybrid vectors and viruses to produce large quantities of recombinant AAV.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: February 16, 1999
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, William M. Kelley, Krishna J. Fisher
  • Hybrid adenovirus-AAV vector and methods of use therefor
    Patent number: 5856152
    Abstract: The present invention provides a hybrid vector construct which comprises a portion of an adenovirus, 5' and 3' ITR sequences from an AAV, and a selected transgene. Other hybrid vectors form a polycation conjugate and incorporate an AAV rep gene in a single particle. These hybrid virus vectors are characterized by high titer transgene delivery to a host cell and the ability to stably integrate the transgene into the host cell chromosome. Also disclosed is the use of the hybrid vectors to produce large quantities of recombinant AAV.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: January 5, 1999
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, William M. Kelley, Krishna J. Fisher