Abstract: The instant disclosure is generally directed to low viscosity, low volatility lubricating compositions. The lubricating composition of the instant disclosure includes an oil of lubricating viscosity that contains a lubricating base oil and a hydrocarbon oil. The hydrocarbon oil makes up least 20 wt % of the oil of lubricating viscosity and has a kinematic viscosity of less than 3.7 c St at 100° C. and a NOACK volatility (measured by ASTM D5800) of less than 25 wt %. The lubricant composition further includes a polyalkenyl succinimide dispersant, and, optionally, other formulation additives. The lubricating compositions have been shown to increase fuel economy in internal combustion engines.

Abstract: Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.

Abstract: The present disclosure is directed to inhibitors of Formula (0), or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction,

Abstract: The present disclosure relates to the production of platelets from megakaryocytes (Mks). In particular, the present disclosure provides systems and methods for the in vitro production of platelets from Mks using a microfluidic bioreactor having a center flow channel and uniform high-shear micrometer slits. Use of this microfluidic bioreactor enables the continuous production of millions of platelets and facilitates real-time and long-term visualization of proplatelet and platelet generation.

Abstract: A microturbine fabricated by a three-level semiconductor batch-fabrication process based on polysilicon surface-micromachining. The microturbine comprises microelectromechanical elements formed from three polysilicon multi-layer surfaces applied to a silicon substrate. Interleaving sacrificial oxide layers provides electrical and physical isolation, and selective etching of both the sacrificial layers and the polysilicon layers allows formation of individual mechanical and electrical elements as well as the required space for necessary movement of rotating turbine parts and linear elements.

Abstract: A compression release mechanism for use in a single or multi-cylinder engine to make the engine easier to hand start. The assembly includes a compression release shaft disposed substantially within the camshaft. The compression release shaft is formed in at least two segments and can therefore be formed accurately, repeatedly and cost effectively using powder metal technology. Consequently, the weight of the flyweight member that is attached to the compression release shaft can be accurately controlled, thereby allowing the compression release mechanism to disengage at a precisely known rotational velocity of the camshaft. The compression release shaft may engage one or more valve actuation devices, which in turn force exhaust valves open during starting engine speeds. The compression release mechanism is conveniently contained within the housing by a housing wall bearing against the flyweight member and a cam bearing against an end of the compression release shaft.

Abstract: A children's handrail assembly consists of four equally spaced connector brackets having three sections of plastic tubing interconnected therebetween. The connector brackets are secured to a standard handrail by means of cable ties which pass through apertures in the connector bracket and pull tightly around the standard handrail. The children's handrail can be applied to either wall mounted or spindle supported standard handrails. When wall mounted, the connector brackets urge against the wall surface. When spindle mounted, an additional cable tie may be employed to secure the bracket to a spindle.

Abstract: The invention provides a method of determining the content of progenitor cells in a hematopoietic cell culture. The method comprises measuring one or more metabolic parameters of the culture, such as oxygen consumption, glucose consumption and/or lactate production, and using the measured parameter(s) to determine the content of progenitor cells.

Abstract: An improved lawn renovating tool for aerating, mulching, dethatching, seeding and fertilizing lawns which is lightweight and easy to use. The tool has a lightweight handle, an elongate tubular shaft with a seed or fertilizer feeding and soil breaking element attached to the bottom portion of the elongate shaft. The seed or fertilizer feeding and soil breaking element is a partially triangular tube having spike-tooth rotatable wheel-type attachments along its base and a series of holes for feeding seed or fertilizer from a feed hopper mounted on the elongate shaft. A damper and control pedal are also included, regulating the flow of seed or fertilizer.

Abstract: The invention is a flow-through bioreactor for the retention and culture of cells in perfused media. The bioreactor is a generally rectangular vessel with inlet and outlet ports in the lid allowing for media flow along the longitudinal axis of the vessel. The inner surface of the bottom wall of the bioreactor has a plurality of generally rectangular grooves having a length, a depth, and a width. The grooves are positioned in the bottom wall such that their length is transverse to the longitudinal axis of the vessel, allowing media flow across the width of the grooves. Cells settle into the grooves, where they proliferate and differentiate, without entering the bulk flow of media through the vessel, thus avoiding loss of cells due to media flow. The preferred grooves have a width to depth ratio of about 1:1 or 2:1. The preferred width of the grooves is about 50 .mu.m to about 5,000 .mu.m, and the preferred depth is about 50 .mu.m to about 5,000 .mu.m.

Abstract: An apparatus for providing a maintenance treatment to a dental tool, the apparatus comprising a station to which the tool is able to be detachably mounted, an agent supply means (for supplying an agent used in the maintenance treatment), and a purging substance supply means. The station has agent conduit means and purging conduit means which are able to be detachably connected to passageway means of the dental tool. The agent supply means is arranged to transmit the agent through the agent conduit means in a manner that the agent contacts portions of agent-benefitted portions of the dental tool. The purging substance supply means is arranged to transmit the purging substance through the purging conduit means in a manner that the purging substance is able to remove particles of the agent from portions of agent-detrimented portions of the dental tool.

Abstract: An airborne surveillance platform utilizes a low aspect ratio delta-shaped aircraft having a radar-transparent hull. The antenna is located within, and stationary relative to, the hull. The antenna comprises planar or linear phased arrays arranged to scan in a continuous pattern in all azimuthal directions. Planar phased arrays can be arranged to scan in a continuous pattern in the range from zenith to nadir or in portions of that range.

Abstract: A hood tilt retardation system comprising a shock absorber mounted on the side of upstanding member near the motor truck engine provides cushioning of the hood descent into its fully open or closed positions in the final segments thereof. This cushioning is augmented by a pair of springs attached to the hood and upstanding member for movement thereabout and functioning as a counterbalance to the hood weight during the hood reciprocal movement between its open and closed positions.

Abstract: Nutrient feed regulation systems for automatic control of nutrient flow rates in controlled environment agriculture installations utilizing nutrient film techniques. Such control is provided by feed regulators each including means defining a metering orifice of fixed flow area and means establishing a constant hydrostatic head across the metering orifice, thus enabling the maintenance of a constant nutrient flow rate to all plant growth containers in both vertically tiered and horizontally arrayed container configurations.