Abstract: A shared ledger operated by a group of network participants according to a set of consensus rules manages and resolves subrogation claims between a clamant and a defendant with arbitration. Evidence regarding the value of the subrogation claim is sent to the shared ledger by the parties to the subrogation claim such as sending data to a smart contract deployed on the shared ledger. The parties to the subrogation claim or entities that are not parties to the subrogation claim may broadcast data relating to fault to the blockchain. The data relating to fault may be evaluated by the parties or entities acting on the parties' behalf to determine fault. A fault determination may be broadcast to the blockchain based upon the analysis of the data relating to fault. Once the claim is resolved, arbitrator may release funds on the chain to the prevailing party or may accept confirmation that any payments have been made between the parties off-chain.

Abstract: The present invention relates to a rapid high-throughput ion-exchange resin assay for determining enzyme activity. This novel assay uses a radiometric technique which separates the radioactive substrate from the product (or the radioactive product from the substrate) by exploiting the differences in the net charges of the molecules using ion-exchange resin. This assay is useful, for example, for studies of enzyme kinetics, the identification of functional sites in the enzyme, and in the automated screening of compound libraries for pharmaceutical drug development.

Abstract: Pyrrolo[2,1-c][1,2,4]thiadiazole or pyrollo[2,1-c][1,2,4]oxadiazoles having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.

Abstract: The current invention relates to compounds of Formula I pharmaceutical compositions and methods of use as nitric oxide synthase inhibitors, wherein the substituents are defined in the application.

Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

Abstract: The present invention relates to a rapid high-throughput ion-exchange resin assay for determining enzyme activity. This novel assay uses a radiometric technique which separates the radioactive substrate from the product (or the radioactive product from the substrate) by exploiting the differences in the net charges of the molecules using ion-exchange resin. This assay is useful, for example, for studies of enzyme kinetics, the identification of functional sites in the enzyme, and in the automated screening of compound libraries for pharmaceutical drug development.

Abstract: The current invention discloses useful bicyclic and tricyclic amidino derivative compounds, pharmaceutical compositions containing these novel compounds, and to their use as nitric oxide synthase inhibitors.

Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

Abstract: The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.

Abstract: There is disclosed a novel amino alcohol amine derivatives of L-N.sup.6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.

Abstract: A cup member defines a cavity for covering an infant's ear, and an annular member extends from an end portion of the cup member. The cup member and the annular member each comprise a first sound attenuating layer of foam material which attenuates high frequency sound and a second sound attenuating layer of a material which attenuates low frequency sound. The annular member has a surface for placing the earmuff against the infant's head. A hydrogel adhesive is disposed on the surface for bonding the earmuff to the infant's head. The hydrogel layer preferably extends along the plane defined by the surface of the annular member and into the cavity defined by the cup member for bonding the earmuff to a substantially hairless portion of the infant's head located behind the pinna.

Abstract: A method for the production of collagenase inducing factor is disclosed which comprises growing the human liver adenocarcinoma cell line SK-HEP-1 in nutrient culture medium at 35.degree.-38.degree. C. and recovering the resulting collagenase inducing factor from the spent cells or conditioned medium.

Abstract: Novel peptide hydroxamic acid derivatives having useful collagenase inhibitory activity and capable of forming affinity resins for the purification of vertebrate collagenase are defined by the following structural formula:R--Pro--Leu--Gly--NHOHwherein R=H or N-protecting group or agarose.

Abstract: A resin chelating agent and process for making it are disclosed. The process comprises reacting the crosslinked product formed from the reaction of an aqueous suspension of a polyethyleneimine with a polycarboxylic acid with a mixture of a caustic agent comprising an alkali metal or alkaline earth metal hydroxide and carbon bisulfide to produce the finished resin. The resin can be produced in both head and powder form and is capable of selectively removing a large number of metallic contaminants from process and waste water streams. It is also essentially insensitive to the presence of alkali metal and alkaline earth metal ions dissolved in said streams.

Abstract: A substantially leak-free arrangement for isolating at least two fluid streams from each other and for conducting each fluid stream into a mixing zone is characterized in a first embodiment by a casing having substantially parallel upstream and downstream partitions, each partition being provided, for each fluid stream, with an orifice of a predetermined cross-section. Defined within the casing between the partitions is a valve chamber in which a valve plate, having a flow passage corresponding to each orifice in the partitions, is moveable from a first, closed, to a second, open, position. The valve plate in the first, closed, position prevents fluid communication between each of the orifices in the first partition and the corresponding orifices in the second partition.

Abstract: A thermal engine system is characterized by a cylinder having a suitable working fluid disposed therein and having a piston reciprocally movable in first and second directions within the cylinder, the piston dividing the cylinder into first and second pressurization regions. In one embodiment, a thermally responsive, expansible member is operatively connected directly at one free terminus thereof to the piston. In an alternate embodiment, the free terminus of the thermally responsive, expansible member is indirectly attached to one or more double-acting piston-cylinders through lever connections. The thermally responsive, expansible member is connected at the second end thereof to suitable means for maintaining the second end of the expansible member in a substantially stationary position.

Abstract: To detect the presence of certain types of hidden flaws within a material having an exposed surface, the surface is tapped at one location to produce sonic vibrations within the material. At another location, an acoustic receiving transducer is coupled to the surface of the material being tested. A characteristic of the electrical signals produced by the transducer which is indicative of the type of flaw to be detected is utilized to denote the presence of a flaw. A mobile foorm of apparatus which detects flaws while traversing the surface of the material and which indicates the location as well as the existence of the flaws is described.