Patents by Inventor William M. Pierce

William M. Pierce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bone-selective osteogenic oxysterol-bone targeting agents
    Patent number: 9683009
    Abstract: Compounds and compositions for the treatment of bone disorders are presented.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: June 20, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Farhad Parhami, Frank Stappenbeck, Michael E. Jung, William M. Pierce, Jr., Kevyn Merten, K. Grant Taylor
  • METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH
    Publication number: 20130029901
    Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.
    Type: Application
    Filed: July 30, 2012
    Publication date: January 31, 2013
    Inventors: William M. PIERCE, JR., K. Grant TAYLOR, Leonard C. WAITE, Kevyn MERTEN
  • METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH
    Publication number: 20120083440
    Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.
    Type: Application
    Filed: October 5, 2011
    Publication date: April 5, 2012
    Inventors: William M. Pierce, JR., K. Grant Taylor, Leonard C. Waite, Kevyn Merten
  • Methods and compounds for the targeted delivery of agents to bone for interaction therewith
    Patent number: 8071575
    Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.
    Type: Grant
    Filed: February 22, 2008
    Date of Patent: December 6, 2011
    Assignee: University of Louisville Research Foundation
    Inventors: William M. Pierce, Jr., K. Grant Taylor, Leonard C. Waite
  • METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH
    Publication number: 20090118164
    Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.
    Type: Application
    Filed: February 22, 2008
    Publication date: May 7, 2009
    Inventors: William M. Pierce, JR., K. Grant Taylor, Leonard C. Waite
  • METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH
    Publication number: 20080221070
    Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion. The Bone Active Portion is derived from an estrogenic agent. Compounds can also include a Blocking Group (RP) that reduces or eliminates the estrogenic activity of the Bone Active Portion.
    Type: Application
    Filed: March 6, 2008
    Publication date: September 11, 2008
    Inventors: William M. Pierce, K. Grant Taylor, Leonard C. Waite
  • Bone targeting compounds for delivering agents to bone for interaction therewith
    Patent number: 7399789
    Abstract: The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or disease to the bone for interaction therewith.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: July 15, 2008
    Assignee: University of Louisville Research Foundation
    Inventors: William M. Pierce, Leonard C. Waite, K. Grant Taylor
  • Bone targeting compounds for delivering agents to the bone for interaction therewith
    Patent number: 7196220
    Abstract: The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or disease to the bone for interaction therewith.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: March 27, 2007
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: William M. Pierce, Jr., Leonard C. Waite, K. Grant Taylor
  • Trailer to vehicle connecting system
    Publication number: 20040108685
    Abstract: The present invention is a system for hooking a trailer to a towing vehicle. The system has a winch attached to the trailer and a cable that wraps around the ball hitch and is attached to a plate on the trailer. By spacing the cable wide at the plate on the trailer and narrow at the ball of the hitch, the trailer is automatically adjusted to position the tongue of the trailer to center it on the ball hitch.
    Type: Application
    Filed: December 2, 2003
    Publication date: June 10, 2004
    Inventor: William M. Pierce
  • Bone targeted inhibitors of carbonic anhydrase
    Patent number: 5641762
    Abstract: The present invention relates to novel compounds useful for the treatment and prophylaxis of degenerative bone disorders and to the preparation thereof. These compounds are particularly characterized by two active moieties, the first of which possesses "bone-seeking" affinity and the second which is an inhibition of the enzyme carbonic anhydrase and/or an inhibitor of bone resorption. The novel compounds of this invention can be administered as pharmaceutically acceptable compositions and in convenient dosage unit form in a method for the treatment and prophylaxis of degenerative bone disorders.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: June 24, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: William M. Pierce, Jr., Leonard C. Waite
  • Topically active ocular thiadiazole sulfonamide carbonic anhydrase inhibitors
    Patent number: 5242937
    Abstract: The present invention is directed to a compound of the formula: ##STR1## or pharmaceutically acceptable salts thereof which are useful in the treatment of glaucoma and in the assessment of corneal function.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: September 7, 1993
    Assignee: Research Corporation Technologies, Inc.
    Inventor: William M. Pierce, Jr.
  • Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors
    Patent number: 5059613
    Abstract: This invention is directed to compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.6 is hydrogen or lower alkyl;each R.sub.1 is hydrogen, lower alkyl, halogen, nitro, trihaloalkyl, lower alkoxy, formyl, lower alkanoyl, loweralkylamino or diloweralkylamino ##STR2## X is O, S or NR.sub.5 ; R.sub.2 is OR.sub.7 or NR.sub.7 R.sub.8 ;each R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl;R.sub.5 R.sub.7 and R.sub.8 are independently hydrogen or lower alkyl;n is 0-3 andm is 0-6.These compounds are useful for treating glaucoma or assessing corneal function in mammals.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: October 22, 1991
    Assignee: Research Corporation Technologies, Inc.
    Inventor: William M. Pierce, Jr.
  • Topically active ocular gem-diacylthiadiazole sulfonamide carbonic anhydrase inhibitors
    Patent number: 5055480
    Abstract: This invention relates to compounds of the following formula useful as a carbonic anhydrase inhibitor:A compound of the formula: ##STR1## and pharmaceutically acceptable salts thereof wherein X is NR.sub.12 ;R.sub.1 is ##STR2## R.sub.2 is ##STR3## R.sub.3 is hydrogen or lower alkyl; R is hydrogen or lower alkyl;each R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl;each R.sub.7 and R.sub.8 are independently hydrogen or lower alkyl;R.sub.6 is OR.sub.10 or NR.sub.10 R.sub.11 ;R.sub.9 is OR.sub.13 OR NR.sub.11 R.sub.13 ;R.sub.10, R.sub.11 R.sub.12, and R.sub.13 are independently hydrogen or lower alkyl; andn and m are independently 0-6.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: October 8, 1991
    Assignee: Research Corporation Technologies, Inc.
    Inventor: William M. Pierce, Jr.