Abstract: Devices and methods for treatment of a patient's vasculature are described. The device includes a self-expanding permeable implant having a radially constrained state and an expanded state with a shortened configuration, a plurality of elongate filaments which are woven together in a tubular braid, and a fixation element. The fixation element may be a hook, barb, protrusion, bioadhesive, or pore. The implant includes at least some nitinol filaments and at least some composite filaments. Methods of treating a cerebral aneurysm are also described. The methods include advancing a permeable implant to the aneurysm, deploying the implant, and delivering embolic material into the cerebral aneurysm adjacent a portion of the permeable implant that spans the neck.

Abstract: Devices and methods for treatment of a patient's vasculature are described. The device includes a self-expanding resilient permeable shell having a radially constrained state and an expanded state with a globular, axially shortened configuration. The permeable shell may be a single layer of braided elongate filaments having first and second ends that are secured at the proximal end of the permeable shell. The devices may also include permeable shells made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described.

Abstract: The present invention extends to methods, systems, and computer program products for iteratively and interactively searching for information. Embodiments of the invention can provide a user with relevant location-specific information in response to a query from the user. Provided information can also be relevant to a user's predicted future behavior. As context for a user is obtained and/or accumulated, such as, for example, through an interactive query dialogue, the probability of providing relevant information in response to a query from the user increases.

Abstract: The present invention extends to methods, systems, and computer program products for iteratively and interactively searching for information. Embodiments of the invention can provide a user with relevant location-specific information in response to a query from the user. Provided information can also be relevant to a user's predicted future behavior. As context for a user is obtained and/or accumulated, such as, for example, through an interactive query dialogue, the probability of providing relevant information in response to a query from the user increases.