Abstract: The present disclosure provides, among other things, a vaccine composition that includes a squalene nanoemulsion (SNE) adjuvant and HPV virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82.

Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.

Abstract: An interstitial recessed cantilever latch mechanism for fiber optic and electrical connectors is disclosed. This mechanism enables the design of more spatially efficient multi-position connectors while retaining the reliability and tactile feedback of traditional connector latch mechanisms. The mechanism also allows the receptacle interface to be substantially simplified, and reduces the number of unique components required by means of a hermaphroditically assembled backshell half.

Abstract: An instrument includes a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to close off a fluidic channel in the body. A cartridge interface is configured to engage the cartridge.

Abstract: An information handling system includes a printed circuit board, a surface mount connector including first and second surface mount connector portions, first and second different pairs, and a ground plane. The first and second surface mount connector portions are mounted on the printed circuit board. The first differential pair is located on the first surface mount connector portion, and the second differential pair is located on the second surface mount connector portion. The ground plane is located in between the first and second surface mount connector portions within the printed circuit board. The first ground via is in physical communication with the ground plane and a first ground pad on a surface of the printed circuit board. The second ground via is in physical communication with the ground plane and a second ground pad on the surface of the printed circuit board.

Abstract: A high throughput system for depositing seed into germination wells of a germination tray. The system comprises a seed distribution subsystem, and an individual seed transfer subsystem structured and operable to transfer individual seeds from wells in a seed storage tray to the seed deposition subsystem. The system additionally comprises a bulk seed transfer subsystem structured and operable to singulate a plurality of bulk seeds and transfer each singulated seed to the seed deposition subsystem, wherein the seed distribution subsystem structured and operable to receive seeds from the individual seed transfer subsystem and the bulk seed transfer subsystem, and deposit the seeds into wells of the seed germination tray.

Abstract: Ultraviolet light disinfection systems expose medical devices, surfaces, patients and healthcare clinicians to UV light having wavelengths consist with killing microorganisms. UV light systems may use logic to govern the operation of UV light sources so as to apply a disinfecting dose of the UV light. UV detectors measure UV light exposure. Enclosures contain medical devices and flood the medical devices with the UV light. Some enclosures accommodate a person. Some UV systems project UV light onto high-touch surfaces of a healthcare environment. Some systems may be deployed within a patient transport vehicle. Some UV systems may be incorporated into medical devices.

Abstract: Compositions, such as consumer products and/or fragrance compositions, that include an adamantyl ester-containing compound.

Abstract: An information handling system includes a printed circuit board, a surface mount connector including first and second surface mount connector portions, first and second different pairs, and a ground plane. The first and second surface mount connector portions are mounted on the printed circuit board. The first differential pair is located on the first surface mount connector portion, and the second differential pair is located on the second surface mount connector portion. The ground plane is located in between the first and second surface mount connector portions within the printed circuit board. The first ground via is in physical communication with the ground plane and a first ground pad on a surface of the printed circuit board. The second ground via is in physical communication with the ground plane and a second ground pad on the surface of the printed circuit board.

Abstract: Methods and systems for managing operation of data processing systems are disclosed. The data processing systems may include a limited number of hardware components. To increase the usable number or types of hardware components, an add-in card or other device may be attached to the data processing system. When connected to the data processing system, these devices may consume power delivered by the data processing system. The devices may cooperate with the host data processing system so that power is consumed in a manner that is less likely to negatively impact operation of the devices and host system.

Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.

Abstract: Disclosed is an operating system (OS) discovery mode that identifies and provides access to OS and/or third-party provided features within an applicable region of a desktop. In some configurations, once the discovery mode is activated, the content displayed by the applicable region is analyzed to identify content usable by OS and/or third-party provided features. Visual cues are rendered in the applicable region near the identified content, highlighting the availability of the OS and/or third-party provided features. Users may interact with the visual cues to manipulate the underlying content or to invoke the OS and/or third-party provided features. OS and/or third-party provided features may modify content displayed by an application, launch an inline micro-experience, crop or export images, etc. While in the discovery mode, visual cues are highlighted as a discovery mouse cursor moves around the desktop.

Abstract: Some embodiments of pacing systems employ wireless electrode assemblies to provide pacing therapy. The wireless electrode assemblies may wirelessly receive energy via an inductive coupling so as to provide electrical stimulation to the surrounding heart tissue. In certain embodiments, the wireless electrode assembly may include one or more biased tines that shift from a first position to a second position to secure the wireless electrode assembly into the inner wall of the heart chamber.

Abstract: A self-contained system is provided for cleaning a food flow path in a food processor. The system can be operably engaged without requiring disassembly and reassembly of the food processor or can be operably engaged after a partial disassembly of the food processor. The system includes a control assembly for directing passage of a solution through the food processor without requiring constant operator oversight. The system can employ available positive pressure water supply, such as public utility water pressure to selectively and automatically push solutions, including rinses, backwards or forwards through a food flow path in the food processor, though typically countercurrent to the normal processing food flow. A manifold assembly includes an intake manifold and a distribution manifold, with an induction port and/or access port in the distribution manifold for introducing additives or agents into a controlled motive stream passing through the manifold assembly.

Abstract: Methods and systems for managing operation of data processing systems are disclosed. The data processing systems may include a limited number of hardware components. To increase the usable number or types of hardware components, an add-in card or other device may be attached to the data processing system. When connected to the data processing system, these devices may consume power delivered by the data processing system. The devices may cooperate with the host data processing system so that power is consumed in a manner that is less likely to negatively impact operation of the devices and host system.

Abstract: Methods and systems for managing operation of data processing systems are disclosed. The data processing systems may include a limited number of hardware components. To increase the usable number or types of hardware components, an add-in card or other device may be attached to the data processing system. To facilitate connection of a variety of types of devices having varying form factors, an interposer may be used. The data processing system may modify a communication topology based on whether a device or the interposer is connected to it to establish communication channels.

Abstract: A map control module receives a stream of map data characterizing a geographic region proximal to a vehicle and outputs a moving map, and the moving map is divisible into a matrix of cells. A map item control receives a stream of point of interest (POI) data characterizing a plurality of POIs within the boundary and categorizes each of the plurality of POIs to define a set of categories. The map item control determines a display location of a map item within the matrix of cells for each of the plurality of POIs and determines an importance for each POI within a same category. The map item control forms a set of clusters of map items. Each map item in a given cluster of map items has a same cell and a same category. The map item control selects a top-item for each cluster of map items.

Abstract: An interstitial recessed cantilever latch mechanism for fiber optic and electrical connectors is disclosed. This mechanism enables the design of more spatially efficient multi-position connectors while retaining the reliability and tactile feedback of traditional connector latch mechanisms. The mechanism also allows the receptacle interface to be substantially simplified, and reduces the number of unique components required by means of a hermaphroditically assembled backshell half.

Abstract: Systems and methods for an improved Internet search engine are provided. According to one embodiment, a search request includes (i) one or more initial constraints to constrain a search of real-time Internet content to a domain name space and (ii) one or more user-specified search terms or phrases. A subset of potential outcomes is provided as feedback to a user by generating a search query to be applied to the content within the domain name space by: (i) identifying company records matching the initial constraint(s) and satisfying one or more sampling criteria by searching a company database; and (ii) incorporating into the search query: (a) domain names of matching company records; and (b) the user-specified search terms or phrases. The subset of potential outcomes are then displayed to the user by performing a limited search of the real-time Internet content based on the structured search query.

Abstract: Systems and methods for an improved Internet search engine are provided. According to one embodiment, a search request is received from an end user via a browser based interface. The search request includes (i) initial constraint(s) to be used by the Internet search engine to constrain a search of real-time Internet content and (ii) user-specified search terms. A structured search query is generated based on company records of a company database matching the initial constraint(s). The search of real-time Internet content is performed and search results are returned by, for each web site domain specified in the structured search query, applying the search term(s) to a predetermined number of web pages for the domain. The search results, including a list of companies associated with the search results, is locally stored and presented to the end user. Interactive filtering and/or ranking of the locally stored search results is then facilitated.