Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.

Abstract: An optical film includes an optically diffusive layer including a plurality of nanoparticles dispersed between and across opposing first and second major surfaces thereof. The plurality of nanoparticles has a nanoparticle size distribution including distinct first and second peaks at respective nanoparticle sizes d1 and d2, wherein 1.5?d2/d1?10. The optically diffusive layer includes a polymeric material bonding the nanoparticles to each other. For a substantially collimated substantially normally incident light, the optical film has, in a visible wavelength, an average specular transmittance VTs and an average total transmittance VTt, and in an infrared wavelength range, an average total transmittance ITt and an average specular transmittance ITs, wherein 0.3?(VTs/VTt)?0.7, (VTs/ITs)?0.25, and (ITs/ITt)?0.7.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: A display system for sensing a finger of a user applied to the display system includes a display panel; a sensor for sensing the finger; a sensing light source configured to emit a first light having a first wavelength W1; and a reflective polarizer disposed between the display panel and the sensor. For a substantially normally incident light, an optical transmittance of the reflective polarizer versus wavelength for a first polarization state has a band edge such that for a first wavelength range extending from a smaller wavelength L1 to a greater wavelength L2 and including W1, where 30 nm?L2?L1?50 nm and L1 is greater than and within about 20 nm of a wavelength L3 corresponding to an optical transmittance of about 50% along the band edge, the optical transmittance has an average of greater than about 75%.

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

Abstract: In accordance with one exemplary embodiment, the present invention provides a sensor system for detecting a change in condition. The system includes a radioactive source. This system also includes at least one radiation detector configured to detect radiation from the radioactive source. Furthermore, the system includes a displacement assembly configured to physically displace in response to the change in condition and configured to change the radiation levels detected by the radiation detector in response to such displacement. Advantageously, this system facilitates non-intrusive communication of information across a physical barrier, via the measurement of changing radiation levels that change in response to a change in condition, for example.

Abstract: A wellhead assembly for use on a well with a blowout preventer stack having a bore therethrough that utilizes an intervention spool sealingly secured between a horizontal tree and the blowout preventer stack to allow the use of a removable valve package positioned in the intervention spool with valve actuators mounted on the exterior of the intervention spool is disclosed.

Abstract: A seal assembly with an accumulator ring for protecting a seal from explosive decompression is disclosed. The accumulator ring and the seal are contained within a seal gland. The seal is made of a material that is susceptible to damage from explosive decompression. When exposed to a high-pressure fluid environment, the accumulator ring fills with a quantity of high-pressure fluid, either by permeation if it is solid or by permeation and/or vents and/or channels leading to a void if it is hollow. During an explosive decompression event, the accumulator ring expands to fill the remaining volume of the seal gland. Then, the accumulator ring exerts an axial compressive or supporting force on the seal for a sufficient amount of time to allow the seal to expel fluid contained in it and minimize the effects of explosive decompression thereto.

Abstract: A seal assembly with an accumulator ring for protecting a seal from explosive decompression is disclosed. The accumulator ring and the seal are contained within a seal gland. The seal is made of a material that is susceptible to damage from explosive decompression. When exposed to a high-pressure fluid environment, the accumulator ring fills with a quantity of high-pressure fluid, either by permeation if it is solid or by permeation and/or vents and/or channels leading to a void if it is hollow. During an explosive decompression event, the accumulator ring expands to fill the remaining volume of the seal gland. Then, the accumulator ring exerts an axial compressive or supporting force on the seal for a sufficient amount of time to allow the seal to expel fluid contained in it and minimize the effects of explosive decompression thereto.

Abstract: A riser connector is provided for connecting a riser to a wellhead assembly having a bore therethrough. The connector includes a housing having a first and a second end. The first end of the housing has an opening and is adapted for mounting to the wellhead assembly with the opening in communication with the bore of the wellhead assembly. The second end has a first opening connectable to the riser having a diameter at least the same as the inner diameter of the riser, and a second opening, having a diameter at least substantially the same as the diameter of the bore of the wellhead assembly. The housing further includes a first conduit connecting the opening in the first end of the housing to the first opening in the second end of the housing, and a second conduit connecting the opening in the first end of the housing to the second opening in the second end of the housing. In use, first well operations are conducted through the riser in the conventional manner.

Abstract: A riser connector is provided for connecting a riser to a wellhead assembly having a bore therethrough. The connector includes a housing having a first and a second end. The first end of the housing has an opening and is adapted for mounting to the wellhead assembly with the opening in communication with the bore of the wellhead assembly. The second end has a first opening connectable to the riser having a diameter at least the same as the inner diameter of the riser, and a second opening, having a diameter at least substantially the same as the diameter of the bore of the wellhead assembly. The housing further includes a first conduit connecting the opening in the first end of the housing to the first opening in the second end of the housing, and a second conduit connecting the opening in the first end of the housing to the second opening in the second end of the housing. In use, first well operations are conducted through the riser in the conventional manner.

Abstract: A clamping connector that can be remotely actuated and locked which is particularly useful in subsea applications for attaching subsea Christmas trees to marine wellheads. The clamping connector includes clamp halves linked by a locking stem. The locking stem is forced into a pre-stressed state by moving the locking stem from a first relaxed to a second pre-stressed position and retained in the second pre-stressed position by a locking collet. A locking collet through which the locking stem extends is moved from a first unlocked position to a second locked position wedged between the locking stem and one or the other of the clamp halves. When the locking collet is in the second locked position, it resists movement of the locking stem from the second pre-stressed position to the first relaxed position. The locking collet is then locked in the second locked position.

Abstract: A wellhead structure having a subsea wellhead (10) connected to the lower end of a collet connector (30). A blowout preventer stack (8) is connected to the upper end of the collet connector (30) and a marine riser (13) is connected to the upper end of the blowout preventer stack (8). The wellhead (10) has an outer wellhead housing (12) fixed to the seabed (B) and an inner wellhead housing (14) supported within the outer wellhead housing (12). Upper hub (16) of outer wellhead housing (12) has an outer profile for mating in a releasably locked position with the collet connector (30). External tensile and bending loads are transmitted directly from the marine riser (13) and blowout preventer stack (8) to the outer wellhead housing (12) along load path L2 bypassing inner wellhead housing (14). One embodiment (FIGS. 5 and 6) shows an inner wellhead housing (14B) extending above the outer wellhead housing (12B) and adapted for separate connection to a small connector (30C) shown in FIG.

Abstract: A tubular joint has a pair of tubular members (10, 12) with end hubs (14, 16) in opposed relation and secured by a clamp (22). A primary seal ring (40) has external tapered sealing surfaces (42, 44) engaging internal tapered sealing surfaces (28, 30) on the hubs (14, 16) to provide a primary seal. Secondary sealing surfaces (32, 36) on the hubs (14, 16) are engaged by O-rings (62, 64) as shown in FIG. 4 to seal against external fluid flow to the seal ring (40). O-rings (62, 64) permit internal fluid flow outwardly from the seal ring (40) as shown in FIG. 3.

Abstract: A fire safe valve which includes a body having an inlet, an outlet, a valve chamber communicating with the inlet and the outlet and having an opening, a bonnet secured to the body and having a bore therethrough with the opening of the bore communicating with the valve chamber opening and defining a back seat surrounding the bore, a valve member, a valve stem connected to the valve member and extending through the bonnet bore, a backseating shoulder on the valve stem, an actuator, the valve stem connecting to the actuator to move the valve member within the valve chamber to open and close flow through, the valve, a temperature sensitive material retaining the valve stem shoulder spaced from said bonnet bore seat during normal operations and allowing additional movement of the valve stem responsive to excessive temperatures to bring the valve stem shoulder into engagement with the bonnet bores seat to backseat and prevent flow of fluids within the valve from escaping therefrom.

Abstract: A preloaded connection for use between subsea tubular members including a flange surrounding one end of one of the tubular members, connecting means surrounding the exterior of the other tubular member, a ring, studs extending through said flange and said ring to secure the ring to said flange, nuts on said studs to secure the flange to the ring, pressure responsive means between said ring and said flange to urge said ring away form said flange to introduce tension in said studs, means carried by said ring for engaging with the external connecting means of said other tubular member, means for moving said engaging means carried by said ring into engagement with said external connecting means, and means for venting said pressure responsive means after engagement is achieved between said engaging means and said external connecting means.

Abstract: The present invention relates to an improved seal assembly for sealing between the interior sealing surface of a well housing and the exterior sealing surface of a hanger landed within the well housing and includes a seal body having a pair of outer lips diverging outwardly for sealing against the housing interior sealing surface and an interior series of annular ridges which have a diameter smaller than the outer diameter of the hanger exterior sealing surface, an upper energizer and a lower energizer for coacting with said lips to move the lips into sealing position and to store the energy of setting to ensure sealing engagement of the lips. The shape of the sealing lips is such that they each provide a sealing surface and a ridge having a greater outer diameter than the sealing surface so that when the seal assembly is being run into the housing any scratches resulting from the engagement of the seal with the interior of the housing is on the ridges and not on the sealing surfaces.

Abstract: A method and apparatus for the protection of downhole equipment from excessive pressure conditions which includes providing structures of volume compensating material which are designed to resist normal pressures expected in the well bore. One form of the invention has a plurality of half sections of volume compensating material positioned around one of the tubular member in the annulus which has fluids that can increase in pressure to a point approaching damage to the interior of exterior member of the annulus. In another application a resilient seal includes a recess into which a ring of volume compensating material is placed to allow a place for fluids to flow when they are subjected to overpressure conditions.

Abstract: An improved tubular joint between two tubular members having their mating ends with inner sealing surfaces tapering outward in the direction toward the other tubular member and with a sealing ring having outer sealing surfaces for engaging the inner sealing surfaces of the tubular members. The improvement lies in the provision of an insert sleeve having a tapered portion and a tubular portion, the insert sleeve is cold forged in place over a damaged sealing surface of one of the tubular members and has a tapered inner sealing surface for sealing with the outer surface of the sealing ring. This improved joint is particularly useful in subsea wellheads. The tight gripping and sealing engagement of the insert sleeve within the tubular member is augmented by grooves within a recess on the interior of the tubular member being repaired or sharp annular teeth around the exterior of the tubular portion of the insert sleeve.

Abstract: The improved joint of the present invention includes a first tubular member having a central bore, a counterbore, and an axially extending first rim having an interior land and groove recess therein and internal seal means near the end of said first rim, a second tubular member having a central bore, a counterbore, an axially extending second rim having an outer diameter less than the inner diameter of said first rim on said first tubular member, an external sealing surface near the base of said second rim and an axially facing stop shoulder at the base of said second rim and extending outward from the exterior of said second rim, a sleeve positioned within and spaced slightly inward from said second rim and sealed to the interior of said second rim at a position near the base thereof and at a position near the outer end thereof, and a port extending through said second tubular member providing communication between the exterior of said second tubular member and the space between said sleeve and the interior