Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: A method and system for fixtureless vision tracking of a target image for use by the vision system when processing subsequent sheets/documents in a sheet handling apparatus. A sheet of material is passed through the sheet handling system to acquire image data within a field of view of the initialization sheet. The acquired image is then filtered and stored/saved in a filtered image data file while an unfiltered image is also retained for the purposes of additional analysis. The filtered image is modified by an erosion technique to form blob images while the unfiltered image is substantially unchanged from the original optical image, i.e., retains the various character strings in their original form. The vision system then performs a dual tier analysis on the blob images and character strings to identify the target image. Additionally, the spatial location of the target image is determined to provide location data for processing subsequent sheet material.