Abstract: The disclosure provides a method for treating a subject afflicted with a tumor derived from a small cell lung cancer (SCLC) having a high tumor mutational burden (TMB) status comprising administering to the subject a monotherapy comprising an anti-PD-1 antibody or a combination therapy comprising an anti-PD-1 antibody and an anti-CTLA-4 antibody. The present disclosure also provides a method for identifying a subject suitable for treatment with an anti-PD-1 antibody or a combination therapy comprising an anti-PD-1 antibody and an anti-CTLA-4 antibody comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: A headlight assembly for assembly adjacent at least one skin component of a vehicle includes a housing supporting at least one light and a lens attached to the housing. The lens includes at least one attribute for engaging the at least one skin component. The attribute may be a pin or an aperture formed in the lens which may extend a distance from a surface of the lens for guiding the skin component. The skin component may be a grille and the attribute may restrict movement of the headlight assembly relative the grille in a Y-axis direction forming a margin therebetween. The attribute may be a channel including a bracket for guiding the skin component, for instance, a facia into the channel. The attribute may be a cavity formed in the lens for receiving an overlapping portion of the skin component, for example, a grille.

Abstract: A subassembly for a vehicle front end includes a grille, a housing supporting at least one light, and a lens attached to said housing. The lens has at least one attribute for engaging said grille. The grille may include at least one extension and the at least one attribute has a shape corresponding with the extension. The at least one attribute may further restrict movement of said lens relative said grille in a Y-axis direction. This ensures consistent margins or gap widths therebetween. The at least one attribute may include an aperture, or a cavity formed in said lens for receiving the extension. The at least one extension may include an overlapping portion of said grille, and the at least one extension may be a loop overlapping at least a portion of said lens.

Abstract: A method of assembling vehicle front end components to a vehicle front end includes the steps of attaching at least one non-skin component to the body, supporting a first skin component using at least one of the at least one non-skin component such that the first skin component is moveable relative the at least one non-skin component, joining a second skin component to the first skin component such that the first skin component and the second skin component are fixed relative one another and moveable relative the at least one non-skin component, and restricting movement of the second skin component relative the at least one non-skin component.

Abstract: A headlight assembly for assembly adjacent at least one skin component of a vehicle includes a housing supporting at least one light and a lens attached to the housing. The lens includes at least one attribute for engaging the at least one skin component. The attribute may be a pin or an aperture formed in the lens which may extend a distance from a surface of the lens for guiding the skin component. The skin component may be a grille and the attribute may restrict movement of the headlight assembly relative the grille in a Y-axis direction forming a margin therebetween. The attribute may be a channel including a bracket for guiding the skin component, for instance, a facia into the channel. The attribute may be a cavity formed in the lens for receiving an overlapping portion of the skin component, for example, a grille.

Abstract: A headlight assembly for assembly adjacent at least one skin component of a vehicle includes a housing supporting at least one light and a lens attached to the housing. The lens includes at least one attribute for engaging the at least one skin component. The attribute may be a pin or an aperture formed in the lens which may extend a distance from a surface of the lens for guiding the skin component. The skin component may be a grille and the attribute may restrict movement of the headlight assembly relative the grille in a Y-axis direction forming a margin therebetween. The attribute may be a channel including a bracket for guiding the skin component, for instance, a facia into the channel. The attribute may be a cavity formed in the lens for receiving an overlapping portion of the skin component, for example, a grille.

Abstract: A headlight assembly for assembly adjacent at least one skin component of a vehicle includes a housing supporting at least one light and a lens attached to the housing. The lens includes at least one attribute for engaging the at least one skin component. The attribute may be a pin or an aperture formed in the lens which may extend a distance from a surface of the lens for guiding the skin component. The skin component may be a grille and the attribute may restrict movement of the headlight assembly relative the grille in a Y-axis direction forming a margin therebetween. The attribute may be a channel including a bracket for guiding the skin component, for instance, a facia into the channel. The attribute may be a cavity formed in the lens for receiving an overlapping portion of the skin component, for example, a grille.

Abstract: A subassembly for a vehicle front end includes a grille, a housing supporting at least one light, and a lens attached to said housing. The lens has at least one attribute for engaging said grille. The grille may include at least one extension and the at least one attribute has a shape corresponding with the extension. The at least one attribute may further restrict movement of said lens relative said grille in a Y-axis direction. This ensures consistent margins or gap widths therebetween. The at least one attribute may include an aperture, or a cavity formed in said lens for receiving the extension. The at least one extension may include an overlapping portion of said grille, and the at least one extension may be a loop overlapping at least a portion of said lens.

Abstract: A method of assembling vehicle front end components to a vehicle front end includes the steps of attaching at least one non-skin component to the body, supporting a first skin component using at least one of the at least one non-skin component such that the first skin component is moveable relative the at least one non-skin component, joining a second skin component to the first skin component such that the first skin component and the second skin component are fixed relative one another and moveable relative the at least one non-skin component, and restricting movement of the second skin component relative the at least one non-skin component.

Abstract: Apparatus and methods for separating a fluid, with the apparatus including a rotatable drum having an inner drum wall and an outer drum wall disposed around the inner drum wall to define a separation passage therebetween. The apparatus also includes radial separator blades that are curved in a circumferential direction and are disposed in the separation passage of the drum, the radial separator blades extending radially at least partially between the inner drum wall and the outer drum wall. The apparatus further includes a first circumferential separator blade that is curved in a radial direction and is disposed in the separation passage of the drum, the first circumferential separator blade extending at least partially around the inner drum wall. The apparatus also includes a housing disposed around the drum and configured to receive a higher-density component of the fluid separated in the separation passage.

Abstract: Apparatus and methods for separating a fluid, with the apparatus including a rotatable drum having an inner drum wall and an outer drum wall disposed around the inner drum wall to define a separation passage therebetween. The apparatus also includes radial separator blades that are curved in a circumferential direction and are disposed in the separation passage of the drum, the radial separator blades extending radially at least partially between the inner drum wall and the outer drum wall. The apparatus further includes a first circumferential separator blade that is curved in a radial direction and is disposed in the separation passage of the drum, the first circumferential separator blade extending at least partially around the inner drum wall. The apparatus also includes a housing disposed around the drum and configured to receive a higher-density component of the fluid separated in the separation passage.

Abstract: A method for implementing at speed bit fail mapping of an embedded memory system having ABIST (Array Built In Self Testing), comprises using a high speed multiplied clock which is a multiple of an external clock of an external tester to sequence ABIST bit fail testing of the embedded memory system. Collect store fail data during ABIST testing of the embedded memory system. Perform a predetermined number of ABIST runs before issuing a bypass order substituting the external clock for the high speed multiplied clock. Use the external clock of the tester to read bit fail data out to the external tester.

Abstract: A method for implementing at speed bit fail mapping of an embedded memory system having ABIST (Array Built In Self Testing), comprises using a high speed multiplied clock which is a multiple of an external clock of an external tester to sequence ABIST bit fail testing of the embedded memory system. Collect store fail data during ABIST testing of the embedded memory system. Perform a predetermined number of ABIST runs before issuing a bypass order substituting the external clock for the high speed multiplied clock. Use the external clock of the tester to read bit fail data out to the external tester.

Abstract: A separator and method according to which substances having relatively high densities are separated from a pressurized flow stream.

Abstract: A separator and method according to which substances having relatively high densities are separated from a pressurized flow stream.

Abstract: A built-in self-test (BIST) system and method for testing an array of embedded electronic devices, the BIST comprising: a shift register device connected to an output pin of an embedded array of electronic devices being tested and for receiving a failure indication signal at a real-time output pin of the device under test, the shift register generating a unique signature in response to receipt of the failure indication; a device for determining whether the generated unique signature is represented in a table comprising known signature values and corresponding bitmaps of prior determined array defects for that device under test; wherein the need to bitmap the array is avoided when a known failure signature is determined.

Abstract: A built-in self-test (BIST) system and method for testing an array of embedded electronic devices, the BIST comprising: a shift register device connected to an output pin of an embedded array of electronic devices being tested and for receiving a failure indication signal at a real-time output pin of the device under test, the shift register generating a unique signature in response to receipt of the failure indication; a device for determining whether the generated unique signature is represented in a table comprising known signature values and corresponding bitmaps of prior determined array defects for that device under test; wherein the need to bitmap the array is avoided when a known failure signature is determined.

Abstract: Retroreflective articles of the invention comprise a continuous base layer and a multi-color polymeric top layer. The invention also includes methods of making such retroreflective articles. The retroreflective articles of the invention provide excellent daytime contrast while maintaining nighttime retroreflectivity. Variously colored segments of polymer are directly and either sequentially or simultaneously coated onto a continuous backing to form a multi-colored top layer. Durability over existing multi-colored retroreflective articles is enhanced by use of a continuous base layer.

Abstract: Outer and inner endwall sections are so profiled that, essentially, the flowpath is straight or flat in the direction of flow. The profiles are defined by lines of revolution about a centerline of a turbine, and shaped as projections upstream from blade tips or bases, tangent to such blade tips or bases, axially, and radially, conforming to a mean obtaining between convex and concave surfaces of the nozzle.

Abstract: A cover plate for an easy access pulley box conduit coupler has pairs of split ear elements extending normal thereto, which each define a slot structure. A pulley shaft extends through opposed walls of the pulley box. In assembly of the box and the cover plate, each slot structure snap fits onto an extended end of said pulley shaft.