Patents by Inventor William Malachowski

William Malachowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDO inhibitors
    Patent number: 9174942
    Abstract: Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: November 3, 2015
    Assignee: NewLink Genetics Corporation
    Inventors: Mario R. Mautino, Sanjeev Kumar, Firoz Jaipuri, Jesse Waldo, Tanay Kesharwani, Nicholas N. Vahanian, Charles J. Link, Judith Lalonde, George Prendergast, Alexander Muller, William Malachowski
  • IDO Inhibitors
    Publication number: 20140323740
    Abstract: Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 30, 2014
    Applicants: NewLink Genetics Corporation, Lankeanau Institute for Medical Research
    Inventors: Mario R. Mautino, Sanjeev Kumar, Firoz Jaipuri, Jesse Waldo, Tanay Kesharwani, Nicholas N. Vahanian, Charles J. Link, Judith Lalonde, George Prendergast, Alexander Muller, William Malachowski
  • IDO inhibitors and methods of use
    Patent number: 8476454
    Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: July 2, 2013
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, Alexander J. Muller, James B. Duhadaway, William Malachowski
  • Methods for the treatment of cancer
    Patent number: 8383613
    Abstract: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: February 26, 2013
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, Alexander J. Muller, James B. DuHadaway, William Malachowski
  • Novel Methods for the Treatment of Cancer
    Publication number: 20110311648
    Abstract: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
    Type: Application
    Filed: July 20, 2011
    Publication date: December 22, 2011
    Inventors: George C. Prendergast, Alexander J. Muller, James B. DuHadaway, William Malachowski
  • Methods for the treatment of cancer
    Patent number: 8008281
    Abstract: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: August 30, 2011
    Assignee: Lankenau Institute for Medical Research
    Inventors: George C. Prendergast, Alexander J. Muller, James B. DuHadaway, William Malachowski
  • IDO Inhibitors
    Publication number: 20110136796
    Abstract: Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.
    Type: Application
    Filed: April 24, 2009
    Publication date: June 9, 2011
    Applicants: NEWLINK GENETICS, LANKEANAU INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Mario R. Mautino, Sanjeev Kumar, Firoz Jaipuri, Jesse Waldo, Tanay Kesharwani, Nicholas N. Vahanian, Charles J. Link, Judith Lalonde, George Prendergast, Alexander Muller, William Malachowski
  • NOVEL IDO INHIBITORS AND METHODS OF USE
    Publication number: 20100233166
    Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.
    Type: Application
    Filed: April 13, 2010
    Publication date: September 16, 2010
    Inventors: George C. Prendergast, Alexander J. Muller, James B. Duhadaway, William Malachowski
  • IDO inhibitors and methods of use
    Patent number: 7714139
    Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: May 11, 2010
    Assignee: Lankenau Institute for Medcial Research
    Inventors: George C. Prendergast, Alexander J. Muller, James B. Duhadaway, William Malachowski
  • "Novel ido inhibitors and methods of use
    Publication number: 20070173524
    Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.
    Type: Application
    Filed: February 20, 2004
    Publication date: July 26, 2007
    Inventors: George Prendergast, Alexander Muller, James Duhadaway, William Malachowski
  • Novel IDO inhibitors and methods of use thereof
    Publication number: 20070105907
    Abstract: Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed.
    Type: Application
    Filed: October 27, 2006
    Publication date: May 10, 2007
    Inventors: George Prendergast, William Malachowski, Alexander Muller, James DuHadaway
  • Novel methods for the treatment of cancer
    Publication number: 20070099844
    Abstract: Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
    Type: Application
    Filed: February 20, 2004
    Publication date: May 3, 2007
    Inventors: George Prendergast, Alexander Muller, James Duhadaway, William Malachowski