Patents by Inventor William Manning

William Manning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12287331
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: September 1, 2023
    Date of Patent: April 29, 2025
    Assignee: Seer, Inc.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • Patent number: 12241899
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Grant
    Filed: March 3, 2023
    Date of Patent: March 4, 2025
    Assignee: Seer, Inc.
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Patent number: 12222349
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: February 11, 2025
    Assignee: Seer, Inc.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • Publication number: 20240288438
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: April 24, 2024
    Publication date: August 29, 2024
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Patent number: 12050222
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Grant
    Filed: August 4, 2023
    Date of Patent: July 30, 2024
    Assignee: Seer, Inc.
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Publication number: 20240219398
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: January 8, 2024
    Publication date: July 4, 2024
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Patent number: 11906526
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Grant
    Filed: August 4, 2023
    Date of Patent: February 20, 2024
    Assignee: SEER, INC.
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Publication number: 20230384318
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: August 4, 2023
    Publication date: November 30, 2023
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Publication number: 20230384317
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: August 4, 2023
    Publication date: November 30, 2023
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Publication number: 20230204596
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: March 3, 2023
    Publication date: June 29, 2023
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Patent number: 11630112
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: April 18, 2023
    Assignee: SEER, INC.
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Patent number: 11428688
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: August 30, 2022
    Assignee: SEER, INC.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • Patent number: 11402378
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: August 2, 2022
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Paul Scott Eastman, William Manning
  • Publication number: 20220057395
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Application
    Filed: September 1, 2021
    Publication date: February 24, 2022
    Applicant: Laboratory Corporation of America Holdings
    Inventors: Paul Scott Eastman, William Manning
  • Publication number: 20210285958
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 16, 2021
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao
  • Publication number: 20210215709
    Abstract: This disclosure provides methods and compositions for biomolecule corona analysis of biofluids. A biofluid may be contacted with a nanoparticle to form a biomolecule corona, and the composition of the resulting corona may be analyzed. Also provided are methods of preparing a biofluid for corona analysis by serial interrogation.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 15, 2021
    Inventors: Xiaoyan Zhao, William Manning, John Blume, Lyndal Hesterberg, Gregory Troiano, Michael Figa, Hope Liou, Shadi Roshdiferdosi
  • Patent number: 10944472
    Abstract: Disclosed embodiments include a small form-factor pluggable (SFP) optical transceiver having optical time domain reflectometer functionality. A monitor processor is included in the transceiver to report link status and failure information to a cloud-based monitoring application. When a fiber optic link is established, the monitor processor remains idle to reduce power consumption by the transceiver. Upon failure of the link, the monitor processor sends a failure report to the monitoring application which can use the data to alert operators to presence and location of optical fiber breaks in the network.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: March 9, 2021
    Assignee: NET2EDGE LIMITED
    Inventor: Timothy William Manning
  • Publication number: 20210013961
    Abstract: Disclosed embodiments include a small form-factor pluggable (SFP) optical transceiver having optical time domain reflectometer functionality. A monitor processor is included in the transceiver to report link status and failure information to a cloud-based monitoring application. When a fiber optic link is established, the monitor processor remains idle to reduce power consumption by the transceiver. Upon failure of the link, the monitor processor sends a failure report to the monitoring application which can use the data to alert operators to presence and location of optical fiber breaks in the network.
    Type: Application
    Filed: July 8, 2020
    Publication date: January 14, 2021
    Inventor: Timothy William Manning
  • Patent number: 10230526
    Abstract: An out-of-band Domain Name System (DNS) security technique uses a cryptographic blockchain for securing and validating DNS data in a chain of custody that exists outside the DNS namespace, allowing validated access to cached DNS information without requiring real-time access to root servers.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: March 12, 2019
    Inventor: William Manning
  • Publication number: 20190049443
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Application
    Filed: October 18, 2018
    Publication date: February 14, 2019
    Inventors: Paul Scott Eastman, William Manning