Patents by Inventor William Manning

William Manning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions, methods and systems for protein corona analysis and uses thereof
    Patent number: 12287331
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: September 1, 2023
    Date of Patent: April 29, 2025
    Assignee: Seer, Inc.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • Systems and methods for sample preparation, data generation, and protein corona analysis
    Patent number: 12241899
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Grant
    Filed: March 3, 2023
    Date of Patent: March 4, 2025
    Assignee: Seer, Inc.
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Compositions, methods and systems for protein corona analysis and uses thereof
    Patent number: 12222349
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: February 11, 2025
    Assignee: Seer, Inc.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • SYSTEMS AND METHODS FOR SAMPLE PREPARATION, DATA GENERATION, AND PROTEIN CORONA ANALYSIS
    Publication number: 20240288438
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: April 24, 2024
    Publication date: August 29, 2024
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • COMPOSITIONS, METHODS AND SYSTEMS FOR PROTEIN CORONA ANALYSIS AND USES THEREOF
    Publication number: 20240264165
    Abstract: This disclosure provides methods and compositions for biomolecule corona analysis of biofluids. A biofluid may be contacted with a nanoparticle to form a biomolecule corona, and the composition of the resulting corona may be analyzed. Also provided are methods of preparing a biofluid for corona analysis by serial interrogation.
    Type: Application
    Filed: March 22, 2024
    Publication date: August 8, 2024
    Inventors: Xiaoyan ZHAO, William MANNING, John BLUME, Lyndal HESTERBERG, Gregory TROIANO, Michael FIGA, Hope LIOU, Shadi ROSHDIFERDOSI
  • Systems and methods for sample preparation, data generation, and protein corona analysis
    Patent number: 12050222
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Grant
    Filed: August 4, 2023
    Date of Patent: July 30, 2024
    Assignee: Seer, Inc.
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • SYSTEMS AND METHODS FOR SAMPLE PREPARATION, DATA GENERATION, AND PROTEIN CORONA ANALYSIS
    Publication number: 20240219398
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: January 8, 2024
    Publication date: July 4, 2024
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Systems and methods for sample preparation, data generation, and protein corona analysis
    Patent number: 11906526
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Grant
    Filed: August 4, 2023
    Date of Patent: February 20, 2024
    Assignee: SEER, INC.
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • COMPOSITIONS, METHODS AND SYSTEMS FOR PROTEIN CORONA ANALYSIS AND USES THEREOF
    Publication number: 20230417744
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Application
    Filed: September 1, 2023
    Publication date: December 28, 2023
    Inventors: Hongwei XIA, Lyndal HESTERBERG, Michael FIGA, Xiaoyan ZHAO, Gregory TROIANO, William MANNING, John BLUME, Omid FAROKHZAD, Matthew MCLEAN, Craig STOLARCZYK, Marwin KO, Theodore Platt
  • SYSTEMS AND METHODS FOR SAMPLE PREPARATION, DATA GENERATION, AND PROTEIN CORONA ANALYSIS
    Publication number: 20230384317
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: August 4, 2023
    Publication date: November 30, 2023
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • SYSTEMS AND METHODS FOR SAMPLE PREPARATION, DATA GENERATION, AND PROTEIN CORONA ANALYSIS
    Publication number: 20230384318
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: August 4, 2023
    Publication date: November 30, 2023
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • SYSTEMS AND METHODS FOR SAMPLE PREPARATION, DATA GENERATION, AND PROTEIN CORONA ANALYSIS
    Publication number: 20230204596
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: March 3, 2023
    Publication date: June 29, 2023
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • Systems and methods for sample preparation, data generation, and protein corona analysis
    Patent number: 11630112
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: April 18, 2023
    Assignee: SEER, INC.
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao, Daniel Hornburg, Martin Goldberg
  • COMPOSITIONS, METHODS AND SYSTEMS FOR PROTEIN CORONA ANALYSIS AND USES THEREOF
    Publication number: 20230076807
    Abstract: This disclosure provides methods and compositions for biomolecule corona analysis of biofluids. A biofluid may be contacted with a nanoparticle to form a biomolecule corona, and the composition of the resulting corona may be analyzed. Also provided are methods of preparing a biofluid for corona analysis by serial interrogation.
    Type: Application
    Filed: August 31, 2022
    Publication date: March 9, 2023
    Inventors: Xiaoyan ZHAO, William MANNING, John BLUME, Lyndal HESTERBERG, Gregory TROIANO, Michael FIGA, Hope LIOU, Shadi ROSHDIFERDOSI
  • Compositions, methods and systems for protein corona analysis and uses thereof
    Patent number: 11428688
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: August 30, 2022
    Assignee: SEER, INC.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • Biomarkers and methods for assessing response to inflammatory disease therapy
    Patent number: 11402378
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: August 2, 2022
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Paul Scott Eastman, William Manning
  • BIOMARKERS AND METHODS FOR ASSESSING RESPONSE TO INFLAMMATORY DISEASE THERAPY
    Publication number: 20220057395
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Application
    Filed: September 1, 2021
    Publication date: February 24, 2022
    Applicant: Laboratory Corporation of America Holdings
    Inventors: Paul Scott Eastman, William Manning
  • SYSTEMS AND METHODS FOR SAMPLE PREPARATION, DATA GENERATION, AND PROTEIN CORONA ANALYSIS
    Publication number: 20210285958
    Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 16, 2021
    Inventors: William Manning, Young Kim, Brandon Kwan-Leong, Hope Liou, Xiaoyan Zhao
  • COMPOSITIONS, METHODS AND SYSTEMS FOR PROTEIN CORONA ANALYSIS AND USES THEREOF
    Publication number: 20210285957
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 16, 2021
    Inventors: Hongwei XIA, Lyndal HESTERBERG, Michael FIGA, Xiaoyan ZHAO, Gregory TROIANO, William MANNING, John BLUME, Omid FAROKHZAD, Matthew MCLEAN, Craig STOLARCZYK, Marwin KO, Theodore Platt
  • COMPOSITIONS, METHODS AND SYSTEMS FOR PROTEIN CORONA ANALYSIS AND USES THEREOF
    Publication number: 20210215685
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 15, 2021
    Inventors: Hongwei XIA, Lyndal HESTERBERG, Michael FIGA, Xiaoyan ZHAO, Gregory TROIANO, William MANNING, John BLUME, Omid FAROKHZAD, Matthew MCLEAN, Craig STOLARCZYK, Marwin KO, Theodore Platt