Abstract: A method of operating a vehicle climate system when an ambient temperature is below a threshold temperature is provided. In response to an ambient temperature being less than a threshold temperature, a controller is adapted to operate a blower motor at a voltage that depends on whether the vehicle is in charge sustain mode or charge deplete mode. In response to an ambient temperature being greater than a threshold temperature, the controller is adapted to operate the blower motor at a voltage that does not depend on whether in the charge sustain or charge deplete modes.

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.