Patents by Inventor William MARKIS

William MARKIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR REDUCING SUBVISIBLE PARTICLES IN A PHARMACEUTICAL FORMULATION
    Publication number: 20240415969
    Abstract: The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.
    Type: Application
    Filed: June 28, 2024
    Publication date: December 19, 2024
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Hanne BAK, John MATTILA, Ning LI, Xiaolin TANG, Daniel B. DIX, Chen LI, William MARKIS
  • PROCESS FOR REDUCING SUBVISIBLE PARTICLES IN A PHARMACEUTICAL FORMULATION
    Publication number: 20190231877
    Abstract: The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.
    Type: Application
    Filed: April 8, 2019
    Publication date: August 1, 2019
    Inventors: Hanne BAK, John MATTILA, Ning LI, Xiaolin TANG, Daniel DIX, Chen LI, William MARKIS
  • PROCESS FOR REDUCING SUBVISIBLE PARTICLES IN A PHARMACEUTICAL FORMULATION
    Publication number: 20160101181
    Abstract: The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.
    Type: Application
    Filed: October 8, 2015
    Publication date: April 14, 2016
    Inventors: Hanne BAK, John MATTILA, Ning LI, Xiaolin TANG, Daniel DIX, Chen LI, William MARKIS