Abstract: The invention relates to a novel choline cocrystal of 5-[(1Z.2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients.

Abstract: A fluid analytical device comprising: a disc (1) rotatable around an axis (2), the disc (1) comprising: a first layer, the first layer comprising: a disc; and at least one microfluidic channel (6) in the disc partially extending from the disc axis (2) to the disc edge; a second layer, the second layer comprising: a disc of substantially the same diameter as the disc of the first layer; and at least one through input port (3) and one through measurement port (4) pair, the input port (3) located near the disc axis (2) and the measurement port (4) located distal from the disc axis (2); wherein when assembled each of the at least one input port (3) and measurement port (4) pair are aligned with one of the at least one microfluidic channels (6); and a disc spinning mechanism (12); a controller (13) for controlling the disc spinning mechanism (12); and a microscope (11) for analysing the fluid through the measurement ports (4) in the rotatable disc (1).

Abstract: Providing an online store interface that maintains continuity of a user browsing experience by layering a product view on top of referring product views or online-store pages such that a user can navigate back to the referring page without needing the previous page to reload, and re-navigate to the point the user left off. Providing the ability for an item preview to continue even when a user navigates the online store interface away from the preview page further preserves browsing continuity. The present technology also provides a mechanism for allowing users to specify favorite categories and have them listed as tabs in the user interface when the online store is browsed with an appropriate device.

Abstract: An exhaust sampling system for an engine is provided. The exhaust sampling system may include a source of exhaust gas, an exhaust collection unit including at least one collection bag that selectively receives the exhaust gas, and a sample probe in fluid communication with the source of exhaust gas that selectively supplies the at least one collection bag with the exhaust gas. The exhaust sampling system may also include a controller that permits flow of the exhaust gas from the sample probe to the at least one collection bag in a first state and prevents flow of the exhaust gas from the sample probe to the at least one collection bag in a second state. The controller may determine an extraction rate of the sample probe based on an ON time of the engine during a test phase.

Abstract: Provided are therapeutic agents such as double-stranded nucleic acids, termed oligonucleotide decoys, pharmaceutical compositions comprising the same, and related methods of modulating nociceptive signaling, for instance, to prevent and/or treat pain.

Abstract: Apparatus, systems, and methods are contemplated for electric powered vertical takeoff and landing (eVTOL) aircraft. Such are craft are engineered to carry safely carry at least 500 pounds (approx. 227 kg) using at least four, and more preferably at least six variable speed tilt rotors. In some embodiments one or more rotors cooperate to generate at least 50% of the lift, and more preferably at least 70% of the lift, during rotorborne flight (e.g., vertical takeoff, hover, etc). At least some of the blades of each of the at least four rotors are not feathered, retracted, or folded during forward flight. At least one of the variable speed tilt rotors is engineered to be optionally powered by multiple motors, and by multiple battery packs or other independently operating electric power sources. The vehicle preferably flies in an autopilot or pilotless mode and has a relatively small (e.g., less than 45? diameter) footprint.

Abstract: A driving simulation system is configured to train a driver. The system includes a simulated driver cockpit which includes a steering wheel and at least one video display providing a simulated driving environment to the driver. The system further includes a computerized simulation control module including programming configured to operate a driving simulation through the simulated driver cockpit. The driving simulation includes driving rules. The programming is further configured to monitor performance of the driver during the driving simulation, compare the performance of the driver to the driving rules, and while the driving simulation is still in operation, provide untextualized feedback to the driver regarding performance of the driver.

Abstract: Method and systems for displaying content items on an information resource include identifying a supplemental content item to append to a DOM tree of the information resource and identifying a first content item displayed in a first container of the information resource. The methods also includes monitoring a position of a predetermined portion of the first content item relative to a viewport of the application and determining, responsive to monitoring the position of the predetermined portion of the first content item, that the first content item is visible within the viewport of the application. The method also includes appending the supplemental content item in a second container at a first position between the first container and an end of the information resource and displaying the supplemental content item within the viewport of the application responsive to detecting a scroll action towards the end of the information resource.

Abstract: A container filling valve may include a shuttle and a drive sleeve that are magnetically coupled. Movement of the drive sleeve may move the shuttle from a position in which the filling valve is closed to a position in which the filling valve is open. A container handling arm may include a distal end configured to hold a container and a proximal end that includes a load cell. A low flow setpoint system may be configured to arrest closing of a filling valve when that filling valve is partially closed. A pressure control system may be configured to maintain a desired pressure in a reservoir or in a flow path from that reservoir. A product recirculation system may be configured to adjust flow rate in the product recirculation system.

Abstract: Apparatus, systems, and methods are contemplated for electric powered vertical takeoff and landing (eVTOL) aircraft. Such are craft are engineered to carry safely carry at least 500 pounds (approx. 227 kg) using a few (e.g., 2-4) rotors, generally variable speed rigid (non-articulated) rotors. It is contemplated that one or more rotors generate a significant amount of lift (e.g., 70%) during rotorborne flight (e.g., vertical takeoff, hover, etc), and tilt to provide forward propulsion during wingborne flight. The rotors preferably employ individual blade control, and are battery powered. The vehicle preferably flies in an autopilot or pilotless mode and has a relatively small (e.g., less than 45? diameter) footprint.

Abstract: In some aspects of the present disclosure, a touch-panel interface includes a plurality of receivers, wherein each of the receivers is coupled to one or more receive lines of a touch panel, and each of the receivers includes a switch capacitor network and an amplifier. The touch-panel interface also includes controller configured to control switches in the switch capacitor network of each of one or more of the receivers to operate each of the one or more of the receivers in one of a plurality of different receiver modes.

Abstract: Embodiments of the disclosure provide an encapsulated compressor overload, an encapsulated compressor relay start, an encapsulated head pressure control switch and a wiring diagram for a circuit for air conditioning units which prevent gases from being ignited by means of encapsulating sparking components, use of solid-state switching devices, and/or wiring circuits in such a way that open contacts do not contain enough energy to produce a spark capable of igniting the atmosphere.

Abstract: A liquid concentrate comprising essentially: (A) 0.1 to 10 wt. % of one or more amphoteric emulsifying agents; (B) 30 to 95 wt. % of one or more nonionic alkoxylated surfactants; (C) 0 to 20 wt. % of one or more glycol-based solubilizers; and (D) 0 to 65 wt. % of one or more organic solvents; wherein component (B) comprises a mixture of C6-C15-alkanol ethoxylates with different carbon numbers for the alkanol unit species, the carbon numbers for the two C6-C15-alkanol ethoxylates which have the highest share in weight in the mixture being at least 1.5 carbon numbers distant from each other, is useful for reducing or eliminating the formation in a liquid hydrocarbon fuel of ice particles having a weight average particle size greater than 1 ?m when said liquid hydrocarbon fuel is cooled to temperatures in the range of from 0 to ?50° C.

Abstract: The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region. The invention also relates to methods of using and methods of making the epitopes of the invention.

Abstract: The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region. The invention also relates to methods of using and methods of making the epitopes of the invention.

Abstract: Methods are provided for fabricating electrochromic devices that mitigate formation of short circuits under a top bus bar without predetermining where top bus bars will be applied on the device. Devices fabricated using such methods may be deactivated under the top bus bar, or may include active material under the top bus bar. Methods of fabricating devices with active material under a top bus bar include depositing a modified top bus bar, fabricating self-healing layers in the electrochromic device, and modifying a top transparent conductive layer of the device prior to applying bus bars.

Abstract: A container filling valve may include a shuttle and a drive sleeve that are magnetically coupled. Movement of the drive sleeve may move the shuttle from a position in which the filling valve is closed to a position in which the filling valve is open. A container handling arm may include a distal end configured to hold a container and a proximal end that includes a load cell. A low flow setpoint system may be configured to arrest closing of a filling valve when that filling valve is partially closed. A pressure control system may be configured to maintain a desired pressure in a reservoir or in a flow path from that reservoir. A product recirculation system may be configured to adjust flow rate in the product recirculation system.

Abstract: Certain aspects pertain to methods of fabricating an optical device on a substantially transparent substrate that include a pre-deposition operation that removes a width of lower conductor layer at a distance from the outer edge of the substrate to form a pad at the outer edge. The pad and any deposited layers of the optical device may be removed in a post edge deletion operation.

Abstract: Method and systems for displaying content items on an information resource include identifying a supplemental content item to append to a DOM tree of the information resource and identifying a first content item displayed in a first container of the information resource. The methods also includes monitoring a position of a predetermined portion of the first content item relative to a viewport of the application and determining, responsive to monitoring the position of the predetermined portion of the first content item, that the first content item is visible within the viewport of the application. The method also includes appending the supplemental content item in a second container at a first position between the first container and an end of the information resource and displaying the supplemental content item within the viewport of the application responsive to detecting a scroll action towards the end of the information resource.

Abstract: Provided are therapeutic agents such as double-stranded nucleic acids, termed oligonucleotide decoys, pharmaceutical compositions comprising the same, and related methods of modulating nociceptive signaling, for instance, to prevent and/or treat pain.