Patents by Inventor William Matsui

William Matsui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OXYSTEROLS THAT ACTIVATE LIVER X RECEPTOR SIGNALING AND INHIBIT HEDGEHOG SIGNALING
    Publication number: 20160206631
    Abstract: This invention relates, e.g., to compositions comprising oxysterol compounds represented by Formula I or Formula II, e.g., comprising one or more of Oxy 16, Oxy 22, Oxy30, Oxy 31, Oxy35, Oxy37, Oxy43, Oxy44, Oxy45 or Oxy47. The compounds are shown to be Hedgehog pathway inhibiting, and to act as agonists for liver X receptor (LXR). Also disclosed are methods of using compositions of the invention to inhibit Hedgehog signaling effects, such as cell proliferation, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Application
    Filed: November 18, 2015
    Publication date: July 21, 2016
    Applicants: JOHNS HOPKINS UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad PARHAMI, Michael JUNG, Khanhlinh NGUYEN, Dongwon YOO, William MATSUI
  • Urothelial differentiation of urothelial carcinoma: a bladder cancer stem cell model
    Patent number: 8784772
    Abstract: The present invention provides a method of treating cancer in a patient (e.g., a human patient) in need thereof, the method comprising administering a therapeutically effective regimen, the regimen comprising administering to a patient in need thereof a compound that targets 67 laminin receptor (67LR). In a particular embodiment, the compound that targets 67LR is an antibody or antibody fragment. In particular, the present invention provides a method of treating cancer comprising administering to a patient in need thereof an antibody that binds to 67LR. The present invention also provides a method of treating cancer comprising administering to a patient in need thereof an antibody conjugate, wherein the antibody conjugate comprises an antibody that binds to 67LR linked to a therapeutic agent, a protein toxin, a cytotoxic agent or other moiety.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: July 22, 2014
    Assignee: The Johns Hopkins University
    Inventors: David M. Berman, William Matsui, Xiaobing He
  • Methods for detecting and monitoring circulating cancer stem cells
    Patent number: 8748113
    Abstract: Provided herein are compositions, methods, and kits useful for detecting whether a subject has or is likely to develop a cancer and for monitoring, staging and examining a cancer patient. Also provide herein are methods for screening compounds.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: June 10, 2014
    Assignee: The Johns Hopkins University
    Inventors: William Matsui, Richard J. Jones, Carol A. Huff
  • METHODS OF USE OF CYCLOPAMINE ANALOGS
    Publication number: 20140107142
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: October 15, 2013
    Publication date: April 17, 2014
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay, William Matsui
  • METHODS OF USE FOR CYCLOPAMINE ANALOGS
    Publication number: 20130108583
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: May 18, 2012
    Publication date: May 2, 2013
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin R. Tremblay
  • METHODS OF USE OF CYCLOPAMINE ANALOGS
    Publication number: 20130108582
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: May 18, 2012
    Publication date: May 2, 2013
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin R. Tremblay
  • Methods of use of cyclopamine analogs
    Patent number: 8227509
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: July 24, 2012
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin R. Tremblay
  • Methods of Use of Cyclopamine Analogs
    Publication number: 20120077834
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: July 27, 2011
    Publication date: March 29, 2012
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin R. Tremblay
  • METHODS OF USE FOR CYCLOPAMINE ANALOGS
    Publication number: 20110230509
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: April 20, 2011
    Publication date: September 22, 2011
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin R. Tremblay
  • Methods for Detecting and Monitoring Circulating Cancer Stem Cells
    Publication number: 20110110931
    Abstract: Provided herein are compositions, methods, and kits useful for detecting whether a subject has or is likely to develop a cancer and for monitoring, staging and examining a cancer patient. Also provide herein are methods for screening compounds.
    Type: Application
    Filed: November 15, 2007
    Publication date: May 12, 2011
    Applicant: The Johns Hopkins Hospital University
    Inventor: William Matsui
  • CANCER STEM CELL EXPRESSION PATTERNS AND COMPOUNDS TO TARGET CANCER STEM CELLS
    Publication number: 20110020221
    Abstract: Described herein are therapeutic targets expressed in cancer stem cells and methods for treating and diagnosing cancer by targeting such cells with antibodies, compounds, nucleic acid, or other therapeutic agent. In one embodiment described herein, therapeutic agents for the treatment of cancer are provided based on the identification of cancer stem cell targets. The present invention also includes therapeutic targets for cancer therapy and cancer stem cell-targeted therapy. The invention includes the treatment of cancer by the administration of compounds or agents that target cancer stem cells.
    Type: Application
    Filed: April 9, 2010
    Publication date: January 27, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: David M. Berman, Xiaobing He, William Matsui
  • METHODS OF USE OF CYCLOPAMINE ANALOGS
    Publication number: 20100286180
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: December 27, 2007
    Publication date: November 11, 2010
    Applicants: Infinity Pharmaceuticals, Inc., Johns Hopkins University
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin Tremblay
  • Urothelial differentiation of urothelial carcinoma: a bladder cancer stem cell model
    Publication number: 20090047212
    Abstract: The present invention provides a method of treating cancer in a patient (e.g., a human patient) in need thereof, the method comprising administering a therapeutically effective regimen, the regimen comprising administering to a patient in need thereof a compound that targets 67 laminin receptor (67LR). In a particular embodiment, the compound that targets 67LR is an antibody or antibody fragment. In particular, the present invention provides a method of treating cancer comprising administering to a patient in need thereof an antibody that binds to 67LR. The present invention also provides a method of treating cancer comprising administering to a patient in need thereof an antibody conjugate, wherein the antibody conjugate comprises an antibody that binds to 67LR linked to a therapeutic agent, a protein toxin, a cytotoxic agent or other moiety.
    Type: Application
    Filed: March 24, 2008
    Publication date: February 19, 2009
    Applicant: The Johns Hopkins University
    Inventors: David M. Berman, William Matsui, Xiaobing He