Patents by Inventor WILLIAM MICHAEL SCHOPPERLE

WILLIAM MICHAEL SCHOPPERLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Podocalyxin and TRA-related antibody, methods of preparation and uses as an anti-cancer therapeutic agent
    Patent number: 10509038
    Abstract: The invention relates to an antibody or an antigen-binding fragment thereof, including a heavy chain and a light chain, with heavy chain complementarity determining regions 1 to 3 having the amino acid sequences of SEQ ID NOS. 1 to 3, respectively, and light chain complementarity determining regions 1 to 3 having the amino acid sequences of SEQ ID NOS. 4 to 6, respectively. In addition, the invention relates to an anti-cancer therapeutic agent including the antibody or the antigen-binding fragment thereof.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: December 17, 2019
    Assignee: CUREMETA THERAPEUTICS, LLC
    Inventors: William Michael Schopperle, Edwin Saavedra Tan, Yawen Ju, Mats Harald Holmqvist, Youngbin Tak, An Mary Holmqvist
  • PODOCALYXIN AND TRA-RELATED ANTIBODY, METHODS OF PREPARATION AND USES AS AN ANTI-CANCER THERAPEUTIC AGENT
    Publication number: 20170328907
    Abstract: The invention relates to an antibody or an antigen-binding fragment thereof, including a heavy chain and a light chain, with heavy chain complementarity determining regions 1 to 3 having the amino acid sequences of SEQ ID NOS. 1 to 3, respectively, and light chain complementarity determining regions 1 to 3 having the amino acid sequences of SEQ ID NOS. 4 to 6, respectively. In addition, the invention relates to an anti-cancer therapeutic agent including the antibody or the antigen-binding fragment thereof.
    Type: Application
    Filed: March 13, 2017
    Publication date: November 16, 2017
    Applicant: CUREMETA THERAPEUTICS, LLC
    Inventors: WILLIAM MICHAEL SCHOPPERLE, EDWIN SAAVEDRA TAN, YAWEN JU, MATS HARALD HOLMQVIST, YOUNGBIN TAK, AN MARY HOLMQVIST
  • SYSTEMS AND METHODS EMPLOYING HUMAN STEM CELL MARKERS FOR DETECTION, DIAGNOSIS AND TREATMENT OF CIRCULATING TUMOR CELLS
    Publication number: 20140275292
    Abstract: The invention relates to systems and methods to detect circulating tumor cells in a blood sample obtained from a cancer patient. Further, this invention relates to systems and methods to determine a diagnosis or prognosis of aggressive and metastatic cancer by determining the presence and/or level of circulating tumor cells in a blood sample obtained from a cancer patient. The detection and diagnosis is based on the presence or absence of cells that express podocalyxin and/or TRA biomarkers.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventor: WILLIAM MICHAEL SCHOPPERLE
  • DEVICE AND METHOD FOR THE DETECTION AND DIAGNOSIS OF AGGRESSIVE AND METASTATIC CANCER AND CANCER STEM CELLS EMPLOYING PODOCALYXIN AND TRA BIOMARKERS
    Publication number: 20140273016
    Abstract: The invention relates to devices and methods to detect podocalyxin and TRA molecules in a biological sample obtained from a patient and therefore, to detect the presence of podocalyxin-expressing and TRA-expressing cancer stem cells in a patient. The invention further relates to devices and methods to determine a diagnosis of aggressive or metastatic cancer by employing podocalyxin and TRA as biomarkers.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventor: WILLIAM MICHAEL SCHOPPERLE
  • SYSTEMS AND METHODS FOR EMPLOYING PODOCALYXIN AND TRA HUMAN STEM CELL MARKERS AS PROGNOSTIC MARKERS FOR AGGRESSIVE AND METASTATIC CANCER
    Publication number: 20140274773
    Abstract: The invention relates to systems and methods to detect podocalyxin-expressing and TRA-expressing cancer stem cells or cancer cells with stem cell-like properties in a tissue cell sample obtained from a localized tumor of a patient, and to determine a diagnosis or prognosis of aggressive and metastatic cancer by employing podocalyxin and TRA human stem cell markers as prognostic markers.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventor: WILLIAM MICHAEL SCHOPPERLE