Abstract: A method for correcting an image made from a system having a plurality of settings wherein the system has optical artifacts which vary according to the settings. The method includes acquiring one reference image of a substantially uniform subject with the system at a first setting. Acquiring a second reference image of the uniform subject with the system at a second setting. Storing both reference images and correcting a subject image acquired by the system by using either the first reference image or the second reference image, depending on the setting at which the subject image was acquired. The method is capable of acquiring and storing multiple reference images and storing them with assignment to multiple settings.