Abstract: Computer-implemented methods and computer systems for an electronic transaction platform that enables the buying and/or selling of securities by users. The methods and systems relate to controlling communication of information during an electronic communication session for trading a financial instrument between an initiating user and one or more invitee users with the assistance of a dealer user or other intermediate entity. When a dealer with whom the initiating user has a relationship does not have a relationship with invitee users that may desire to trade for the security, a second dealer can be included in the electronic communication session, where the second dealer has a relationship with such invitee users. Various levels of participation are available for each user and correspond to what information each user is provided during the electronic communication session.

Abstract: The present application is generally directed to systems, methods, and devices for diagnostics for sensing and/or identifying pathogens, genomic materials, proteins, and/or other small molecules or biomarkers. In some implementations, a small footprint low cost device provides rapid and robust sensing and identification. Such a device may utilize microfluidics, biochemistry, and electronics to detect one or more targets at once in the field and closer to or at the point of care.

Abstract: The present disclosure is directed to a medical device for inhibiting the activity of bacterial collagenase and/or a matrix metalloproteinase (MMP). In some embodiments, the medical device comprises a polymer that includes a transition metal or a salt thereof. In some embodiments, the medical device comprises an alloy that has at least one of a transition metal or a transition metal salt.

Abstract: The present application is generally directed to systems, methods, and devices for diagnostics for sensing and/or identifying pathogens, genomic materials, proteins, and/or other small molecules or biomarkers. In some implementations, a small footprint low cost device provides rapid and robust sensing and identification. Such a device may utilize microfluidics, biochemistry, and electronics to detect one or more targets at once in the field and closer to or at the point of care.

Abstract: The blood-brain barrier penetrant procaspase-3-activating drug, PAC-1, has been identified as an effective approach to inducing immune stimulatory destruction of cancer cells. PAC-1 induces cleavage of MLH1 in cancer cells, and studies show that inactivation of MLH1 leads to increased mutational burden and neoantigen presentation by major histocompatibility complex (MHC) products. Herein is described a mechanistic-based strategy to bring the power of immunotherapy in an effective fashion for treatment of cancer.

Abstract: The present application is generally directed to systems, methods, and devices for diagnostics for sensing and/or identifying pathogens, genomic materials, proteins, and/or other small molecules or biomarkers. In some implementations, a small footprint low cost device provides rapid and robust sensing and identification. Such a device may utilize microfluidics, biochemistry, and electronics to detect one or more targets at once in the field and closer to or at the point of care. In some implementations, the systems and methods herein implement a reader device, an assay cartridge, and a mobile or external device configured to receive abiological sample, test the biological sample, and provide test results to a patient or user associated with the patient. The test results may be packaged with additional information, including symptoms suffered by the patient, a diagnosis, and follow-up instructions.

Abstract: A method of treating a biobased feedstock derived from agricultural resources and specifically from the non-distillate products of fermentation-derived renewable fuel and distilled spirit processes. The separation of thermally labile components from biobased feedstocks result in materials that are thermally stable and better suited for subsequent melt processing in a polymer matrix.

Abstract: The present application is generally directed to systems, methods, and devices for diagnostics for sensing and/or identifying pathogens, genomic materials, proteins, and/or other small molecules or biomarkers. In some implementations, a small footprint low cost device provides rapid and robust sensing and identification. Such a device may utilize microfluidics, biochemistry, and electronics to detect one or more targets at once in the field and closer to or at the point of care.

Abstract: Embodiments as disclosed herein may include a sensor including a luminophor exposed to a fluid flow path. The luminophor may emit light in response to illumination by an excitation light source. The magnitude of light emitted by the luminophor in response to illumination may be determined. It can be determined if this magnitude is within a threshold of the baseline magnitude and an alarm state set based on this determination. This alarm state may indicate that the luminophor has reached an end-of-life state or otherwise should be replaced.

Abstract: Thermal targeting technology is used to continuously adjust boiler target temperature to the minimum necessary to satisfy the required heating load. Responsive to and initiated by a first call for heat, boiler target temperature is reduced by a predetermined amount upon or subsequent to the call for heat. Once the boiler temperature reaches this new target, a call timer is activated. If demand for heat is satisfied before a time set point is reached, the system ceases providing additional heat energy until the next heat demand. Responsive to and initiated by a next call for heat, the boiler target temperature is again reduced by the predetermined amount upon or subsequent to this next call for heat. Each time the heat demand is satisfied within the predetermined time interval, the boiler target temperature is reduced. If heat demand is not satisfied, a thermal boost is provided at set time intervals until the call for heat is removed.

Abstract: A method of treating a biobased feedstock derived from agricultural resources and specifically from the non-distillate products of fermentation-derived renewable fuel and distilled spirit processes. The separation of thermally labile components from biobased feedstocks result in materials that are thermally stable and better suited for subsequent melt processing in a polymer matrix.

Abstract: Embodiments of a dissolved oxygen sensor are disclosed herein. Embodiments as disclosed herein may include a window of optically transparent material disposed in an opening in a fluid flow path, where a luminophor is attached to the side of the window exposed to the fluid in the flow path. An optical probe may be disposed opposite the window from the fluid flow path on an axis at an angle to the window fluid flow path. The optical probe includes an excitation light source for illumination of the luminophor and a reference light source. An optical reception guide is configured to conduct light from the luminophor to a photodiode adjacent to the end of the optical reception guide distal the window when the luminophor is illuminated by the excitation light source. The optical probe is configured to determine a measure of oxygen concentration of the fluid in the flow path.

Abstract: The problem with healthcare information today is that all of the information used to track a patient's entire encounter is not only stored in disparate systems or databases, but there are individual records or forms that are just stored as paper or images that need to be included as part of the encounter's “total picture.” The search tool links all of these disparate data sets and also converts the paper documents into data text and allows the user to search across all of the information that makes up an episode of care. Users have the ability to query large amounts of multiple data sources into a consolidated view of actionable information with immediate results. This information reduces time and increases the consistency of information for the end user. This can be used on a pre or post pay basis by either the payers or providers, clinical research entities and legal firms.

Abstract: Embodiments of a dissolved oxygen sensor are disclosed herein. Embodiments as disclosed herein may include a window of optically transparent material disposed in an opening in a fluid flow path, where a luminophor is attached to the side of the window exposed to the fluid in the flow path. An optical probe may be disposed opposite the window from the fluid flow path on an axis at an angle to the window fluid flow path. The optical probe includes an excitation light source for illumination of the luminophor and a reference light source. An optical reception guide is configured to conduct light from the luminophor to a photodiode adjacent to the end of the optical reception guide distal the window when the luminophor is illuminated by the excitation light source. The optical probe is configured to determine a measure of oxygen concentration of the fluid in the flow path.

Abstract: Thermal targeting technology is used to continuously adjust boiler target temperature to the minimum necessary to satisfy the required heating load. Responsive to and initiated by a first call for heat, boiler target temperature is reduced by a predetermined amount upon or subsequent to the call for heat. Once the boiler temperature reaches this new target, a call timer is activated. If demand for heat is satisfied before a time set point is reached, the system ceases providing additional heat energy until the next heat demand. Responsive to and initiated by a next call for heat, the boiler target temperature is again reduced by the predetermined amount upon or subsequent to this next call for heat. Each time the heat demand is satisfied within the predetermined time interval, the boiler target temperature is reduced. If heat demand is not satisfied, a thermal boost is provided at set time intervals until the call for heat is removed.

Abstract: A method of coupling diatonic harmonicas that increases the musical range of the diatonic harmonicas being coupled. Diatonic harmonicas are stacked and secured together by a clamping mechanism in order to form an instrumental assembly that is more versatile than a single diatonic harmonica. An ideal key is first determined according to a selected musical piece. The ideal key provides a foundation from which an initial harmonica and a subsequent harmonica are selected from a plurality of harmonicas. Each of the plurality of harmonicas is tuned in a musical key that is either major or minor. The musical key of the initial harmonica is determined according to the ideal key, while the musical key of the subsequent harmonica is determined from the chromatic scale. Once the initial harmonica and the subsequent harmonica are selected, they are coupled together by the clamping mechanism.

Abstract: An invoice processing system includes a requisition and catalog server (referred to as a Req/Cat Web, or RCW, server), a procurement services system (SAP), and a requester terminal (browser). ReqCat Web allows requesters to input requirements (requisitions) which ReqCat then passes to SAP, which creates purchase orders, sends them to vendors for fulfillment, receives the vendors invoices, and prepares the payments. Commodities may be designated as either receivable or non-receivable, and this designation is stored in ReqCat web and passed to SAP on inbound requisitions. Payments on invoices received for non-receivable items are approved via a positive confirmation process, and payments on invoices received for receivable items are approved via a negative confirmation process. Positive acceptance of an invoice by a requester of commodities triggers automatic generation of a goods received (move) ticket.

Abstract: An invoice processing system includes a requisition and catalog server (referred to as a Req/Cat Web, or RCW, server), a procurement services system (SAP), and a requester terminal (browser). ReqCat Web allows requesters to input requirements (requisitions) which ReqCat then passes to SAP, which creates purchase orders, sends them to vendors for fulfillment, receives the vendors invoices, and prepares the payments. Commodities may be designated as either receivable or non-receivable, and this designation is stored in ReqCat web and passed to SAP on inbound requisitions. Payments on invoices received for non-receivable items are approved via a positive confirmation process, and payments on invoices received for receivable items are approved via a negative confirmation process. Positive acceptance of an invoice by a requester of commodities triggers automatic generation of a goods received (move) ticket.