Abstract: This invention relates to modified MOF materials, methods of preparing them and processes using them. A modified MOF of the invention is modified by impregnating a MOF with an inorganic metal salt. The starting MOF contains at least one linker or ligand which contains an aryl amino group as part of its structure. These modified MOFs are able to adsorb either basic or acidic toxic industrial compounds (TIC). The modified MOFs can be used to remove TICs from various gaseous streams such as air.

Abstract: This invention relates to metal organic framework (MOF) compositions, methods of preparing them and methods of using them. The MOF compositions are characterized in that at least a portion of the linker molecule is an amino containing organic linker. The MOF also has a crystal size of greater than 1 ?m and has been treated with an acid wash to provide a MOF in which at least 55% of the amino groups are activated amino groups of the form —NH2. The MOF compositions are useful in adsorbing various contaminants from various gas stream. One specific example is adsorbing NO2 from an air stream.

Abstract: We provide an ostomy collection device including: a housing defining a collecting volume for receiving and storing waste from an ostomy appliance, the housing including an inlet for fluidly connecting to an outlet of an ostomy appliance so that waste from the ostomy appliance flows into the collecting volume; and a cover layer positioned over an external surface of the housing.

Abstract: A modular tire pressure leak detection system includes a tire that supports a vehicle and a sensor unit mounted on the tire. The sensor unit detects real-time tire parameters inside the tire and transmits the parameters to a processor. A plurality of modules are in electronic communication with the processor. The plurality of modules include a pre-processing module that receives the parameters and applies a set of operations to generate pressure time series data, a leak detection module that receives the pressure time series data and determines a leak rate of the tire, and a post-processing module that receives the leak rate of the tire and analyzes the leak rate of the tire with determinations from a plurality of conditions. A leak alert is issued by the post-processing module based upon the analysis of the leak rate of the tire and the determinations from the plurality of conditions.

Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: An incorrect copy of a record of data can be prevented from being transmitted to a distributed ledger system. A first file can be received and can include information, in audio or video form, with a description of a subject matter of the record of data and with an authorization to transmit the copy to the distributed ledger system. The first file can be sent to a device. A second file can be received from the device and can include information that confirms that the description of the subject matter, included in the first file, is correct, and that confirms that an entity, which controlled production of the first file, has permission to authorize causing the copy to be transmitted to the distributed ledger system. The correct copy can be caused, based on a receipt of the first and the second files, to be transmitted to the distributed ledger system.

Abstract: An intervertebral implant may include an anterior plate forming a first monolithic structure defining a first end of the implant, and including at least two screw holes each configured to receive a bone screw; and a plurality of coils extending from the anterior plate about a periphery of the implant. The screw holes may be angled such that, when the implant is inserted between two adjacent vertebrae, bone screws are guided into the adjacent vertebrae.

Abstract: A valve for endovascular heart valve repair that provides improved sealing of the valve against the native wall. The valve assembly has a sealing region at a distal end of the valve. The sealing region having a delivery position and a sealing position, wherein in the delivery position, the sealing region has a first length, and in the sealing position, the sealing region has a second length less than the first length and a thickness in the sealing position is greater in the sealing position than in the delivery position.

Abstract: A ostomy collection system and an ostomy collection device (10) including: a housing (12) formed of first and second parts, which together define a top (18), base (14) and wall (16) which enclose a collecting volume for receiving and storing waste from an ostomy appliance, the first part including the top (18) and having an inlet (30) for fluidly connecting to an outlet of an ostomy appliance so that waste from the ostomy appliance flows into the collecting volume, and the second part of the housing being disconnectable from the first part of the housing.

Abstract: A replacement heart valve prosthesis for transcatheter repair of a native valve, the replacement heart valve comprises a valve construct mounted to the exterior surface of an expandable frame. The frame comprises an expandable region near the distal end of the frame, and a cusp region near the proximal region comprising a plurality of valve attachment features. The valve construct may be attached to the valve construct at least at the valve attachment features. The replacement heart valve prosthesis of present disclosure may be a more durable and long-lasting valve that has added benefits by placing valve tissue between the expandable frame and native cardiac tissue.

Abstract: The disclosure provides a novel process and synthetic intermediates for making belzutifan, a HIF-2a inhibitor, useful for the treatment of certain VHL-related indications and cancer.

Abstract: A system stores associates a database query with a name and stores versions of the database query. The system allows applications to execute a specific version of the database query by specifying the name of the database query and a version identifier. For example, the database query may be exposed as an endpoint of a REST API and invoked using calls to the REST API. This allows the applications to be designed without including the query definition within the code of the application. Continuous delivery of database query is performed by creating a new version of the database query that are tested using applications in a test environment. Once the new version of a database query meets test criteria, the new version of the database query is executed by applications running in production environment by sending API requests that identify the query name and the new version.

Abstract: The present embodiments generally relate to the treatment of produced water comprising one or more water soluble polymers, wherein such treatment comprises: adding to the produced water at least one iron complex; and degrading at least a portion of the one or more water soluble polymers. This treatment may result in a reduction of the viscosity of said produced water and/or the degradation of the water soluble polymers which are contained therein.

Abstract: A liquefied gas system for capturing boil-off gas and reversibly adsorbing the boil-off gas on an adsorbent for later desorption and use comprises a first vessel for storing liquefied gas; a means for delivering gas from the first vessel to a system endpoint; a second vessel for storing boil-off gas emitted from the first vessel, the second vessel containing at least one adsorbent; a means for delivering boil-off gas from the first vessel to the second vessel, whereby the boil-off gas is reversibly stored on the at least one adsorbent; and a means for delivering the stored boil-off gas from the second vessel to the system endpoint. Also disclosed is a method of capturing boil-off gas from a liquefied gas system, wherein the captured boil-off gas is captured on an adsorbent for further use in the system. In one embodiment of the system and the method, the liquefied gas is liquid hydrogen, and the captured boil-off gas is used to power a hydrogen fuel cell.

Abstract: A replacement heart valve assembly where the valve is loaded into the catheter distally, and separately from the stent. The valve has a locking member and the stent has a locking channel. Once in the expanded position, the valve is pulled towards the stent until the locking member is engaged with the locking channel.

Abstract: A packaging system for storing a deployable medical device within a sterilized environment includes a sealed container; a tray disposed within the sealed container; a catheter assembly comprising at least one sheath; a deployable medical device engaged with the catheter assembly; and a sterilizing fluid. The tray comprises a first chamber; a second chamber in fluid communication therewith; and at least a third chamber between the first and second chambers, and in fluid communication with at least the first chamber. The deployable medical device is disposed within the tray in a storage configuration, in which the deployable medical device is disposed within the first chamber in a partially deployed state distally from a distal end of the catheter and the catheter assembly spans between the first chamber and the second chamber. The sterilizing fluid contacts at least a part of the deployable medical device in the storage configuration.

Abstract: The method for storing streaming media includes receiving, from a user device, a request to navigate to a requested time of a media stream. The method also includes determining whether a block of media segments that have a time interval that overlaps with the requested time is stored at the server. The method also includes retrieving the block of media segments from long-term memory in accordance with a determination that the block of media segments is not stored at the server. The method also includes traversing the block of media segments that have a time interval that overlaps with the requested time of the media stream to seek and identify a media segment corresponding to the requested time of the media stream. The method also includes streaming a media stream to the user device that begins at the media segment corresponding to the requested time of the media stream.