Abstract: An instrument for facilitating transseptal delivery of a cardiac therapeutic device is positionable in a left ventricle. The instrument includes an elongate shaft having a tubular lumen, the shaft having a proximal portion and a distal portion actively steerable between a generally straight position and a curved position. An external pull wire and an internal pull wire are each actuatable to move the distal portion to the curved position. The external pull wire extends internally through the proximal portion of the shaft and longitudinally along the exterior of the distal portion of the shaft, while the internal pull wire extends internally through the proximal portion of the shaft adjacent to the external pull wire, and extends internally through the distal portion of the shaft.

Abstract: An incubation chamber that may be provided in modular form in order to provide flexibility in flow rate and/or residence time of a product stream is disclosed. Assemblies including such incubation chambers for purification of biomolecules are also disclosed, as are methods for biomolecule purification, and in particular, methods for virus inactivation in an incubation chamber or in a plurality of incubation chambers arranged in series.

Abstract: An apparatus of one embodiment translates computer code from a first programming language to a second programming language. The apparatus includes an interface, a memory, and a processor. The interface is operable to receive a compiler output that is associated with source code written in a first programming language. The memory is operable to store the compiler output. The processor is communicatively coupled to the interface and the memory and is operable to analyze the data structures within the compiler output, build an internal representation of the source code based on the compiler output, and create a source code template associated with a second programming language.

Abstract: An apparatus of one embodiment translates computer code from a first programming language to a second programming language. The apparatus includes an interface, a memory, and a processor. The interface is operable to receive a compiler output that is associated with source code written in a first programming language. The memory is operable to store the compiler output. The processor is communicatively coupled to the interface and the memory and is operable to analyze the data structures within the compiler output, build an internal representation of the source code based on the compiler output, and create a source code template associated with a second programming language.

Abstract: An apparatus of one embodiment translates computer code from a first programming language to a second programming language. The apparatus includes an interface, a memory, and a processor. The interface is operable to receive a compiler output that is associated with source code written in a first programming language. The memory is operable to store the compiler output. The processor is communicatively coupled to the interface and the memory and is operable to analyze the data structures within the compiler output, build an internal representation of the source code based on the compiler output, and create a source code template associated with a second programming language.

Abstract: An apparatus of one embodiment translates computer code from a first programming language to a second programming language. The apparatus includes an interface, a memory, and a processor. The interface is operable to receive a compiler output that is associated with source code written in a first programming language. The memory is operable to store the compiler output. The processor is communicatively coupled to the interface and the memory and is operable to analyze the data structures within the compiler output, build an internal representation of the source code based on the compiler output, and create a source code template associated with a second programming language.

Abstract: The present invention is a disposable, presterilized bioreactor formed of molded plastic, having a top and body attached to each other. One or more ports are formed in the top, side and bottom of the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports, access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment locations are guaranteed through the use of the molded port features.

Abstract: The present invention is a disposable bioreactor formed of molded plastic. The bioreactor is presterilized and has a top and body sealed to each other. One or more ports are formed in the top and side of the housing. Preferably at least one port is below the liquid/air level for the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports or access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment location is also guaranteed through the use of the molded port features. The molded plastic allows for greater flexibility in material selection to reduce or eliminate lipid or cholesterol binding.

Abstract: The invention provides a disposable cell culture bioreactor manifold system for use in coupling sensors, fluid samplers, conduits, and the like, to a cell culture bioreactor in a sterile manner. The disposable bioreactor manifold system includes an externally attachable bioreactor manifold connector body for fluidly attaching modular sensor arrangements that measure physical variables and other parameters of medium contained within a bioreactor, as well as medium sampling components, and other connections, as well as at least one conduit fluidly connecting connecting the bioreactor manifold connector body with a pump for pumping fluids between the bioreactor and the bioreactor manifold connector body.

Abstract: The invention described herein provides an embedded wireless device such as a RFID tag molded into separate housing formed of any thermoplastic material compatible to that of the plastic material as the device to which the housing is to be attached. Subsequently, the housed tag assembly can be thermally bonded onto the device through many means which are well known and accepted in the industry.

Abstract: The invention described herein provides an embedded wireless device such as a RFID tag molded into separate housing formed of any thermoplastic material compatible to that of the plastic material as the device to which the housing is to be attached. Subsequently, the housed tag assembly can be thermally bonded onto the device through many means which are well known and accepted in the industry.

Abstract: The present invention is a disposable bioreactor formed of molded plastic. The bioreactor is presterilized and has a top and body sealed to each other. One or more ports are formed in the top and side of the housing. Preferably at least one port is below the liquid/air level for the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports or access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment location is also guaranteed through the use of the molded port features. The molded plastic allows for greater flexibility in material selection to reduce or eliminate lipid or cholesterol binding.

Abstract: A filtration apparatus is provided wherein a filtration membrane is positioned by gaskets on feed plates and filtrate plates rather than being bonded thereto.

Abstract: The invention described herein provides an embedded wireless device such as a RFID tag molded into separate housing formed of any thermoplastic material compatible to that of the plastic material as the device to which the housing is to be attached. Subsequently, the housed tag assembly can be thermally bonded onto the device through many means which are well known and accepted in the industry.

Abstract: A pharmaceutical composition which composition comprises an insulin sensitiser and a pharmaceutically acceptable carrier therefor, wherein the composition is arranged to provide a modified release of the insulin sensitiser and the use of such composition in medicine.

Abstract: A pharmaceutical composition which composition comprises an insulin sensitiser and a pharmaceutically acceptable carrier therefor, wherein the composition is arranged to provide a modified release of the insulin sensitiser and the use of such composition in medicine.

Abstract: A pharmaceutical composition which composition comprises an insulin sensitiser and a pharmaceutically acceptable carrier therefor, wherein the composition is arranged to provide a modified release of the insulin sensitiser and the use of such composition in medicine.

Abstract: A pharmaceutical composition which composition comprises an insulin sensitiser and a pharmaceutically acceptable carrier therefor, wherein the composition is arranged to provide a modified release of the insulin sensitiser and the use of such composition in medicine.

Abstract: Controlled release dosage forms useful in the treatment and/or prophylaxis of dementia, including Alzheimer's disease, in mammals, and for enhancing amyloid precursor protein processing along a non-amyloidogenic pathway in patients suffering from, or at risk of developing, Alzeimer's disease.