Abstract: A monitoring system for care protocols, comprising sensors connected to electronic devices to input data from a patient, where sensors measure critical values from a patient; an interface for receiving data and allowing users to write and change process control in real time; a processor connected to the interface to receive input parameters, wherein the processor calculates output values based on the input parameters compared to the critical value to determine whether the output values are outside acceptable range; means for setting critical values, ranges of critical value, and alarm points when the critical values are outside of the range; where the interface receives critical patient parameters and the interface includes a manual input and a machine input from one or more sensors; and wherein the system calculates and monitors critical steps or values for a patient and enables the output values for monitoring or display, in real time.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.

Abstract: A remote view playback system for use by medical practitioners to improve patient outcomes, including a patient database and data storage engine including means for collecting and storing data from any number of electronic devices and instructions for transmitting data to any number of electronic devices and for storing data associated with the patient records and/or data to be stored as quality data; a communication hub for collecting, agnostically, data from any number of electronic devices and instructions for transmitting data to any number of electronic devices, and for storing data associated with the patient records to be stored as quality data, and providing access to all data, so that data from multiple disparate sources can be acquired and consolidated within a unified view; optionally, at least one monitoring station; and a user interface rules engine to collect, store and process data in real time, compose views that organize data, notify end-users based on execution steps defined by end-users, di

Abstract: A system for improving patient outcomes, including a data storage and transfer network; a communication hub for collecting data from and transmitting data to, agnostically, electronic devices, for time stamping and storing data, and translating data received and sent; and a rules engine for transmitting data to any number of electronic devices or receiving and sending data via the network, and a user interface rules engine for receiving data and accessing patient medical conditions that provides the user with ability to select any point in time during the patient treatment to review details and create guidance rules so that data can be acquired, consolidated and actionable insights can be delivered in real time; a continuous quality improvement tool engine that provides a user friendly means of defining data search scripts to acquire the required data for analysis.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.

Abstract: The present disclosure relates to ribonucleic acid (RNA)-based therapeutic compositions and in particular a messenger RNA (mRNA) based therapeutic composition. In one embodiment, the RNA-based therapeutic composition may include a mineral-coated substrate, RNA complexes bound to the mineral-coated substrate, and a lyoprotectant. The RNA complexes may include RNA complexed with a complexing agent. The composition may be lyophilized to a dry powder. The mineral-coated substrate may serve to stabilize and promote the transfection efficiency of the RNA complexes after lyophilization. In some embodiments, the mineral-coated substrate includes mineral-coated microparticles (MCMs). In other embodiments, the mineral-coated substrate is a mineral-coated glass vial.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.

Abstract: A retainer assembly for securing a mantle to a mainshaft of a gyratory crusher. The retainer assembly includes a headnut and a burn ring that are joined to each other prior to installation. The headnut includes a first and a second series of bores that each extend though the annular headnut. A series of jacking bolts are installed in the second series of bores and a series of connector are installed in the first series of bores. The combination of the headnut and burn ring are installed on the mainshaft. Once in place, the connectors are removed and a series of cylinders are positioned in the first series of bores. The cylinders are pressurized to create a gap between the headnut and the burn ring. The series of jacking bolts are rotated to maintain the gap and one or more shims can be positioned in the gap. The cylinder are removed and a headnut cover is installed to protect the headnut. During removal of the headnut, the cylinders can be reinstalled and pressurized.

Abstract: The invention concerns an Interoperability Environment comprising: a core software engine comprising means to collect and transfer electronic data from any number of sources including medical devices, clinical information systems, hospital information systems, a means to apply rules to improve compliance with hospital approved protocols, standards and guidances, a means to update all subsystems using any given parameter when the parameter is updated in the official recognized source of truth for that parameter, a means to populate the CIS with all required patient information, while at the same time maintaining all quality and process control data in a format supporting advanced analytics separate from the CIS data, a means to communicate notifications to any number of remote electronic devices without limitation of platform and comprising a hardware eco system comprising means to collect, translate, store and send electronic data to the core software engine for any electronic source via communication methods

Abstract: A retainer assembly for securing a mantle to a mainshaft of a gyratory crusher. The retainer assembly includes a headnut and a burn ring that are joined to each other prior to installation. The headnut includes a first and a second series of bores that each extend though the annular headnut. A series of jacking bolts are installed in the second series of bores and a series of connector are installed in the first series of bores. The combination of the headnut and burn ring are installed on the mainshaft. Once in place, the connectors are removed and a series of cylinders are positioned in the first series of bores. The cylinders are pressurized to create a gap between the headnut and the burn ring. The series of jacking bolts are rotated to maintain the gap and one or more shims can be positioned in the gap. The cylinder are removed and a headnut cover is installed to protect the headnut. During removal of the headnut, the cylinders can be reinstalled and pressurized.

Abstract: The present invention provides methods to improve a cancer patient's response to immune checkpoint inhibitor (ICI) therapy, and functional test to predict likelihood of response. Specifically, the invention provides methods to improve patient's response to immune checkpoint inhibitors using modulators and to predict response to the combination of immune checkpoint inhibitors and modulators.

Abstract: This invention relates to methods of increasing the sensitivity of tumors to anti cancer therapies including antibody therapy, chemotherapy, radiotherapy, and therapies targeting cell signaling pathways such as the MAPK and PI3K pathways and receptor tyrosine kinases (e.g. EGFR). By increasing sensitivity of tumors to these agents, this invention will: (a)Prolong response in already responsive subjects; (b) Increase response rates by converting non-responsive patients into responsive patients; (c) Reverse treatment-induced resistance of tumors to anticancer therapy; and (d) Decrease treatment-associated toxicities by decreasing therapy dosages required for response. The invention also describes predictive tests, to identify patients most likely to respond to the combination treatments.

Abstract: The present disclosure generally relates to additive manufacturing of an object using both a digital light processing (DLP) projector and a focused energy source to irradiate a photopolymerizable material, and apparatuses and methods for the same. The DLP projector irradiates and cures an outer perimeter of the object, and the focused energy source irradiates and cures an inner region of the object. In a preferred embodiment, irradiation by both the DLP projector and the focused energy source occur from underneath a tank holding the photopolymerizable material and through a transparent window.

Abstract: In some embodiments, a method for enforcing hearing protection safety compliance can include: obtaining one or more images of an ear of a user; preprocessing the one or more images to localize the user's ear and/or a hearing protection device (HPD) worn thereabout; providing the one or more preprocessed images to a classification network; receiving an estimated attenuation value as output of the classification network, the estimated attenuation value corresponding to an estimate of the noise attenuation provided by the HPD work about the user's ear; and automatically enforcing compliance with a safety standard using the estimated noise attenuation value.

Abstract: A monitoring system for care protocols, comprising sensors connected to electronic devices to input data from a patient, where sensors measure critical values from a patient; an interface for receiving data and allowing users to write and change process control in real time; a processor connected to the interface to receive input parameters, wherein the processor calculates output values based on the input parameters compared to the critical value to determine whether the output values are outside acceptable range; means for setting critical values, ranges of critical value, and alarm points when the critical values are outside of the range; where the interface receives critical patient parameters and the interface includes a manual input and a machine input from one or more sensors; and wherein the system calculates and monitors critical steps or values for a patient and enables the output values for monitoring or display, in real time.

Abstract: A remote view playback system for use by medical practitioners to improve patient outcomes, including a patient database and data storage engine including means for collecting and storing data from any number of electronic devices and instructions for transmitting data to any number of electronic devices and for storing data associated with the patient records and/or data to be stored as quality data; a communication hub for collecting, agnostically, data from any number of electronic devices and instructions for transmitting data to any number of electronic devices, and for storing data associated with the patient records to be stored as quality data, and providing access to all data, so that data from multiple disparate sources can be acquired and consolidated within a unified view; optionally, at least one monitoring station; and a user interface rules engine to collect, store and process data in real time, compose views that organize data, notify end-users based on execution steps defined by end-users, di

Abstract: A system for improving patient outcomes, including a data storage and transfer network; a communication hub for collecting data from and transmitting data to, agnostically, electronic devices, for time stamping and storing data, and translating data received and sent; and a rules engine for transmitting data to any number of electronic devices or receiving and sending data via the network, and a user interface rules engine for receiving data and accessing patient medical conditions that provides the user with ability to select any point in time during the patient treatment to review details and create guidance rules so that data can be acquired, consolidated and actionable insights can be delivered in real time; a continuous quality improvement tool engine that provides a user friendly means of defining data search scripts to acquire the required data for analysis.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.