Abstract: The present disclosure relates to ribonucleic acid (RNA)-based therapeutic compositions and in particular a messenger RNA (mRNA) based therapeutic composition. In one embodiment, the RNA-based therapeutic composition may include a mineral-coated substrate, RNA complexes bound to the mineral-coated substrate, and a lyoprotectant. The RNA complexes may include RNA complexed with a complexing agent. The composition may be lyophilized to a dry powder. The mineral-coated substrate may serve to stabilize and promote the transfection efficiency of the RNA complexes after lyophilization. In some embodiments, the mineral-coated substrate includes mineral-coated microparticles (MCMs). In other embodiments, the mineral-coated substrate is a mineral-coated glass vial.

Abstract: The platform is directed to various aspects of content transmission. The platform causes a viewing device to receive fragment-level metadata associated with a first fragment of content. The platform receives a request for a second fragment of the content, immediately subsequent to the first fragment of the content. The platform determines that the second fragment of the content is not stored at a content storage device at a time of receiving the request, and that the second fragment of the content is expected to be stored at the content storage device within a defined time period. Responsive to these determinations, the platform holds the received request for the defined time period. The platform determines, prior to expiration of the defined time period, that the second fragment of the content is stored at the content storage device, and transmits the second fragment of the content to the viewing device.

Abstract: A system for coupling a shroud to a case associated with a gas turbine engine includes the case having a mounting pad, and the shroud having a surface that faces the case. The system includes a load spreader having a spreader surface in contact with the surface of the shroud and a locator pin coupled to the mounting pad and the load spreader to couple the shroud to the case. The system includes a load spreader retainer coupled to the load spreader. The load spreader retainer is to distribute a force to the load spreader. The system includes a biasing system coupled about the mounting pad that includes a spring arm configured to apply the force to the load spreader retainer to maintain the spreader surface of the load spreader in contact with the surface of the shroud.

Abstract: Embodiments of negative pressure wound therapy systems, apparatuses, and methods for operating the systems and apparatuses are disclosed. In some embodiments, the apparatus includes a negative pressure source, a connector port, at least one switch, and a controller. The negative pressure source is connected through the connector port to either (i) a wound dressing having a canister configured to store fluid aspirated from the wound or (ii) a wound dressing without a canister between the connector port and the wound dressing. The controller determines, based on a signal received from the at least one switch, whether the canister is positioned in the fluid flow path and adjusts one or more operational parameters of negative pressure wound therapy based on the determination. The switch is activated by the connection of either the canister or canisterless wound dressing to the apparatus.

Abstract: A tubular support structure for use in an elongate intravascular medical device comprises an elongate tubular body, a patterned frame structure formed within the elongate tubular body, an inner lumen axially disposed within the elongate tubular body, and a first set of floating tabs axially spaced apart along the patterned frame structure. Each of the first set of floating tabs has a cantilevered end affixed to the patterned frame structure and a free end configured for translating relative to the patterned frame structure and then engaging the patterned frame structure as the tubular support structure is laterally deflected in a first bending direction.

Abstract: A peak current mode ‘PCM’ controller comprising control logic arranged to produce a series of digital control values derived from a voltage sense signal, control logic arranged to produce a digital slope compensation value, a first digital to analogue converter ‘DAC’ arranged to receive the series of digital control values and output a corresponding analogue control voltage, a second DAC arranged to receive the digital slope compensation value and output a corresponding analogue slope compensation voltage, an analogue differential integrator arranged to receive the analogue control voltage and the analogue slope compensation voltage, integrate the analogue slope compensation voltage, subtract the integrated slope compensation voltage from the analogue control voltage, and output the result of the subtraction as an analogue output voltage, a comparator arranged to compare the analogue output voltage to a voltage of an analogue current sense signal and produce an output signal when the analogue current sense si

Abstract: Apparatus and methods are disclosed for selection of characters from an electronic user interface. In one embodiment, a letter selection interface displays letters in a row, some of which are recordable by an input interpreter and others that are unrecordable. In one embodiment, unrecordable letters visually separate letters that are both (1) recordable, and (2) assigned to different but adjacent selection buttons. In response to received touch-screen activations, an interpreter records recordable letter selections and a display displays both recordable and unrecordable letter selections. The interpreter composes a sequence of the recorded letters. An algorithm identifies alternatives to the recorded sequence by editing one or more letters of the sequence, such that each edit changes a selected letter to an adjacent unrecordable letter. The algorithm outputs words that match the originally composed sequence or one of the identified alternatives.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.

Abstract: Pre-ground plastics of small particle size not more than 2 mm are co-fed into a solid fossil fuel fed entrained flow partial oxidation gasifier. High solids concentrations in the feedstock stream can be obtained without significant impact on the feedstock stream stability and pumpability. A consistent quality of syngas can be continuously produced, including generation of carbon dioxide and a carbon monoxide/hydrogen ratio while stably operating the gasifier and avoiding the high tar generation of fluidized bed or fixed bed waste gasifiers and without impacting the operations of the gasifier. The subsequent syngas produced from this material can be used to produce a wide range of chemicals.

Abstract: Pre-ground plastics of small particle size not more than 2 mm are co-fed into a solid fossil fuel fed entrained flow partial oxidation gasifier. High solids concentrations in the feedstock stream can be obtained without significant impact on the feedstock stream stability and pumpability. A consistent quality of syngas can be continuously produced, including generation of carbon dioxide and a carbon monoxide/hydrogen ratio while stably operating the gasifier and avoiding the high tar generation of fluidized bed or fixed bed waste gasifiers and without impacting the operations of the gasifier. The subsequent syngas produced from this material can be used to produce a wide range of chemicals.

Abstract: Densified textile aggregates are co-fed with a fuel into a partial oxidation gasifier. High solids concentrations in the feedstock composition can be obtained without significant impact on the feedstock composition stability and pumpability. A consistent quality of densified textile derived syngas can be continuously produced, including generation of carbon dioxide and a carbon monoxide/hydrogen ratio while stably operating the gasifier and avoiding the high tar generation of fluidized bed or fixed bed waste gasifiers and without impacting the operations of the gasifier. The densified textile derived syngas quality, composition, and throughput are suitable for produce a wide range of chemicals and polymers, including methanol, acetic acid, methyl acetate, acetic anhydride, and cellulose esters through a variety of reaction schemes in which at least a portion of the chemical or polymer originates with densified textile derived syngas.

Abstract: Apparatus, methods and systems are disclosed for interacting with an electronic device, including inputting letters. One embodiment of the apparatus includes buttons and a text output field displayed on a touch-sensitive display screen. Each button is assigned one or more letters. The text output field displays text and tentative letter selection indicators. In one embodiment of the method, the device records button actuations that ambiguously identify letter selections. With each actuation, a tentative letter selection indicator becomes appended to the end of the contents of the text output field. Upon activation of a button such as a spacebar button, or in response to an event such as expiration of a time period, a language algorithm disambiguates the recorded ambiguously identified letter selections and returns a word suggestion. The returned word replaces a sequence of appended tentative letter selection indicators displayed in the text output field.

Abstract: Shoulder joint implants are disclosed herein for use in shoulder reconstruction that are configured to facilitate the inclusion a central bone screw for augmented bone fixation. The implant can include a baseplate (or metaglene) configured to secure a glenosphere or other prosthetic component to the glenoid. To facilitate lateral or proximal insertion of a central bone screw through the implant, a throughbore defined along the central axis of the metaglene can be widened to accommodate the maximum diameter of the screw. To enable fixation of the glenosphere to the metaglene, a collet can be configured to engage the smaller diameter of a glenosphere coupling element and inserted into the central throughbore. The collet and the bone screw can be separate parts, thereby making insertion of the bone screw optional. Alternatively, the collet and bone screw can be integrated together to form a unitary construct.

Abstract: Apparatus and methods are disclosed for selection of characters from an electronic user interface. In one embodiment, a letter selection interface displays letters in a row, some of which are recordable by an input interpreter and others that are unrecordable. In one embodiment, unrecordable letters visually separate letters that are both (1) recordable, and (2) assigned to different but adjacent selection buttons. In response to received touch-screen activations, an interpreter records recordable letter selections and a display displays both recordable and unrecordable letter selections. The interpreter composes a sequence of the recorded letters. An algorithm identifies alternatives to the recorded sequence by editing one or more letters of the sequence, such that each edit changes a selected letter to an adjacent unrecordable letter. The algorithm outputs words that match the originally composed sequence or one of the identified alternatives.

Abstract: A container for storing and transporting elongated objects, such as smoker's articles, or other small objects, which container has a container lid or closure and a container receptacle. The container lid is mounted on the receptacle for pivoting movement relative thereto and is openable to provide full access to the interior of the container and the object stored therein, and is closable to prevent access thereto. The container incorporates a child-resistant opening mechanism, and a seal which cooperates between the container lid and the receptacle in the closed position of the container lid to prevent odors from escaping the container interior, to preserve freshness of objects stored in the interior of the container and/or to seal the container interior from moisture or other contaminants.

Abstract: Pre-ground plastics of small particle size not more than 2 mm are co-fed into a solid fossil fuel fed entrained flow partial oxidation gasifier. A syngas composition can be made by charging an oxidant and a feedstock composition comprising recycle plastics and a solid fossil fuel to a gasification zone within a gasifier; gasifying the feedstock composition together with the oxidant in said gasification zone to produce said syngas composition; and discharging at least a portion of said syngas composition from said gasifier; wherein the recycled plastics are added to a feed point comprising a solid fossil fuel belt feeding a grinder after the solid fossil fuel is loaded on the belt, a solid fossil fuel belt feeding a grinder before the solid fossil fuel is loaded onto the belt, or a solid fossil fuel slurry storage tank containing a slurry of said solid fossil fuel ground to a size as the size fed to the gasification zone.

Abstract: Apparatus and methods are disclosed for selection of characters from an electronic user interface. In one embodiment, a letter selection interface displays letters in a row, some of which are recordable by an input interpreter and others that are unrecordable. In one embodiment, unrecordable letters visually separate letters that are both (1) recordable, and (2) assigned to different but adjacent selection buttons. In response to received touch-screen activations, an interpreter records recordable letter selections and a display displays both recordable and unrecordable letter selections. The interpreter composes a sequence of the recorded letters. An algorithm identifies alternatives to the recorded sequence by editing one or more letters of the sequence, such that each edit changes a selected letter to an adjacent unrecordable letter. The algorithm outputs words that match the originally composed sequence or one of the identified alternatives.

Abstract: A retainer assembly for securing a mantle to a mainshaft of a gyratory crusher. The retainer assembly includes a headnut and a burn ring that are joined to each other prior to installation. The headnut includes a first and a second series of bores that each extend though the annular headnut. A series of jacking bolts are installed in the second series of bores and a series of connector are installed in the first series of bores. The combination of the headnut and burn ring are installed on the mainshaft. Once in place, the connectors are removed and a series of cylinders are positioned in the first series of bores. The cylinders are pressurized to create a gap between the headnut and the burn ring. The series of jacking bolts are rotated to maintain the gap and one or more shims can be positioned in the gap. The cylinder are removed and a headnut cover is installed to protect the headnut. During removal of the headnut, the cylinders can be reinstalled and pressurized.

Abstract: Chemical recycling facilities for processing mixed plastic waste are provided herein. Such facilities have the capability of processing mixed plastic waste streams and utilize a variety of recycling facilities, such as, for example, solvolysis facility, a pyrolysis facility, a cracker facility, a partial oxidation gasification facility, an energy generation/energy production facility, and a solidification facility. Streams from one or more of these individual facilities may be used as feed to one or more of the other facilities, thereby maximizing recovery of valuable chemical components and minimizing unusable waste streams.