Patents by Inventor William N. Pappano

William N. Pappano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELECTIVE BCL-2 INHIBITORS IN COMBINATION WITH AN ANTI-PD-1 OR AN ANTI-PD-L1 ANTIBODY FOR THE TREATMENT OF CANCERS
    Publication number: 20190336496
    Abstract: This invention pertains to a method for the treatment of cancer in a subject comprising administering to the subject an effective amount of a selective BCL-2 inhibitor or a prodrug or pharmaceutically acceptable salt thereof in combination with an effective amount of an anti-PD-1 antibody or an anti-PD-L1 antibody.
    Type: Application
    Filed: February 15, 2019
    Publication date: November 7, 2019
    Inventors: Tamar Uziel, Joel D. Leverson, William N. Pappano, Dipica B. Maganbhai Haribhai, Rebecca Mathew, Fred Kohlhapp, Cherie K. Donawho
  • SMYD2 inhibitors
    Patent number: 9598381
    Abstract: The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: March 21, 2017
    Assignee: AbbVie Inc.
    Inventors: Gary G. Chiang, William N. Pappano, Ramzi F. Sweis, Zhi Wang
  • Inhibitors of histone methyltransferase G9a
    Patent number: 9284272
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating cancer, inflammation, or autoimmune disease in a subject, or for inhibiting histone methyltransferase G9a.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: March 15, 2016
    Assignee: AbbVie Inc.
    Inventors: Marina A. Pliushchev, Gary G. Chiang, William N. Pappano, Michael R. Michaelides, Ramzi F. Sweis
  • SMYD2 INHIBITORS
    Publication number: 20160031838
    Abstract: The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.
    Type: Application
    Filed: July 29, 2015
    Publication date: February 4, 2016
    Inventors: Gary G. Chiang, William N. Pappano, Ramzi F. Sweis, Zhi Wang
  • INHIBITORS OF HISTONE METHYLTRANSFERASE G9a
    Publication number: 20150274660
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating cancer, inflammation, or autoimmune disease in a subject, or for inhibiting histone methyltransferase G9a.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 1, 2015
    Inventors: Marina A. Pliushchev, Gary G. Chiang, William N. Pappano, Michael R. Michaelides, Ramzi F. Sweis
  • Metalloprotease activation of myostatin, and methods of modulating myostatin activity
    Patent number: 7572599
    Abstract: It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: August 11, 2009
    Assignees: The Johns Hopkins University School of Medicine, Wisconsin Alumni Research Foundation, Wyeth
    Inventors: Se-Jin Lee, Alexandra C. McPherron, Daniel S. Greenspan, William N. Pappano, Neil Wolfman, Kathy Tomkinson