Patents by Inventor William Nikolic

William Nikolic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Generation of transgenic human soluble amyloid precursor protein alpha expressing mice
    Patent number: 8008539
    Abstract: The present invention relates to a novel animal model for neurological degenerative diseases, especially autism, relating to overexpression of human secreted APP-alpha. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals. Moreover, a method for the evaluation of the in vivo effects of a test compound on secreted APP-alpha expression and autism pathology in these animals is provided.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: August 30, 2011
    Assignee: University of South Florida
    Inventors: Jun Tan, William Nikolic, Huyan Hou