Abstract: An insertion system includes a main body and a side port mounted at an angle relative to the main body. The side port is sized to receive a guide wire. The insertion system also includes one or more wire guides mounted to the main body and aligned with the side port. The insertion system further includes a handle mounted to the main body.

Abstract: The disclosure provides processes for preparing a compound of Formula (I):

Abstract: The present pet waste station system is made up of a plurality of units having a sod section which fits into a tray. The method of preparing the system includes growing the sod section apart from the tray for a period. The sod section has live grass, a root system and a soil medium. Once the root system is established in the soil medium, the sod section is placed into the tray, which has a bottom, a series of walls and a ledge with a plurality of interlocking nodes. Two units can connect by engaging interlocking nodes from one unit to interlocking nodes of another unit. Once connected, the overlapping ledges form a seal that prevents liquid from escaping between two units when the pet waste station system is in use.

Abstract: The disclosure provides processes for preparing a compound of Formula (I).

Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.

Abstract: The present pet waste station system is made up of a plurality of units having a sod section which fits into a tray. The method of preparing the system includes growing the sod section apart from the tray for a period. The sod section has live grass, a root system and a soil medium. Once the root system is established in the soil medium, the sod section is placed into the tray, which has a bottom, a series of walls and a ledge with a plurality of interlocking nodes. Two units can connect by engaging interlocking nodes from one unit to interlocking nodes of another unit. Once connected, the overlapping ledges form a seal that prevents liquid from escaping between two units when the pet waste station system is in use.

Abstract: The disclosure provides processes for preparing a compound of Formula (I).

Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.

Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)—N—(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

Abstract: The invention provides ?-sulfonamide ?-keto esters and amides in which the ?-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.

Abstract: The invention provides ?-sulfonamide ?-keto esters and amides in which the ?-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.

Abstract: A process for preparing Z-5-carboxymethylene-1,3-dioxolan-4-ones is provided which includes the steps of reacting a bis-ketal or bis-acetal of tartaric acid with a potassium containing base to form the carboxymethylene-1,3-dioxolan-4-one. A process for preparing HIV integrase inhibitors employing the carboxymethylene-1,3-dioxolan-4-one inhibitor is also provided.

Abstract: An automatic pump control device for an injection pump used to inject fluid (typically methanol) into oil or natural gas wells to prevent freezing. The device enables the pump to operate at rates as low as one full stroke per 1.5 minutes (i.e., 0.67 stroke/min), substantially slower than current rates of approximately fifteen strokes per minute. The device comprises a main body; an extension air pilot; a retraction air pilot; a toggle mechanism that actuates the extension air pilot to extend the pump piston, that at the end of the extension stroke actuates a retraction air pilot to retract the pump piston, and that automatically continues the two stroke cycle; a drive mechanism for driving the toggle mechanism; an overstroke mechanism to prevent over driving the retraction air pilot at the end of its stroke; an optional stroke speed adjustment valve; a circuit to circulate and transport a gas; and piston, spool, and sleeve for switching the path of the gas.

Abstract: The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) process, comprising: contacting a compound of formula (II): with hydrogen under a suitable pressure in the presence of an iridium complex of the formula (R2)IrL+X? wherein L is a chelating diene, X is a non coordinating anion, and R2 is selected from

Abstract: A process for preparing Z-5-carboxymethylene-1,3-dioxolan-4-ones is provided which includes the steps of reacting a bis-ketal or bis-acetal of tartaric acid with a potassium containing base to form the carboxymethylene-1,3-dioxolan-4-one. A process for preparing HIV integrase inhibitors employing the carboxymethylene-1,3-dioxolan-4-one inhibitor is also provided.

Abstract: The present invention relates to a process for the preparation of ?-chloroketones from readily available alkyl esters by the reaction of a sulfoxonium ylide on said alkyl esters to generate a keto sulfoxonium ylide that is in turn treated with anhydrous HCl.

Abstract: The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) 1

Abstract: This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.