Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonizes or partially agonizes) NLRP3 that are useful, e.g., for treating a condition, disease or disorder in which an increase in NLRP3 signaling may correct a deficiency in innate immune activity (e.g., a condition, disease or disorder associated with an insufficient immune response) that contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Abstract: The present invention comprises a method for audio/video conferencing. In a preferred embodiment, the method comprises using a dynamic threshold value to determine whether there is speech on a line. One aspect, the method comprises determining a dynamic threshold value based on one or more characteristics of signals received on a port, associating that dynamic threshold value with the port; and comparing one or more characteristics of signals subsequently received on the port to the dynamic threshold value. Signals received over a plurality of ports are summed, but for ports whose signal characteristics have a specified relationship to the dynamic threshold value associated with that port, signals are not contained in the sum.

Abstract: The present invention comprises a method for audio/video conferencing. In a preferred embodiment, the method comprises using a dynamic threshold value to determine whether there is speech on a line. One aspect, the method comprises determining a dynamic threshold value based on one or more characteristics of signals received on a port, associating that dynamic threshold value with the port; and comparing one or more characteristics of signals subsequently received on the port to the dynamic threshold value. Signals received over a plurality of ports are summed, but for ports whose signal characteristics have a specified relationship to the dynamic threshold value associated with that port, signals are not contained in the sum.

Abstract: The present invention comprises a method for audio/video conferencing. In a preferred embodiment, the method comprises using a dynamic threshold value to determine whether there is speech on a line. One aspect, the method comprises determining a dynamic threshold value based on one or more characteristics of signals received on a port, associating that dynamic threshold value with the port; and comparing one or more characteristics of signals subsequently received on the port to the dynamic threshold value. Signals received over a plurality of ports are summed, but for ports whose signal characteristics have a specified relationship to the dynamic threshold value associated with that port, signals are not contained in the sum.

Abstract: An audio conferencing apparatus and method. The apparatus includes a data bus, such as a TDM bus, a controller, and an interface circuit that receives audio signals from a plurality of conference participants and provides digitized audio signals in assigned time slots over the TDM bus. The audio conferencing platform also includes a plurality of digital signal processors (DSPs) adapted to communicate on the TDM bus with the interface circuit. At least one of the DSPs sums a plurality of the digitized audio signals associated with conference participants who are speaking, to provide a summed conference signal. This DSP provides the summed conference signal to at least one of the other DSPs, which removes the digitized audio signal associated with a speaker whose voice is included in the summed conference signal, to provide a customized conference audio signal to each of the speakers.

Abstract: A conferencing method that conducts an audio conference over the Internet. The method includes receiving digitized audio signals, summing a plurality of received audio signals that contain speech, providing a summed conference signal from the summed plurality of audio signals with an audio conference mixer, transcoding the summed conference signal, and streaming the transcoded summed signal onto the Internet.

Abstract: The present invention comprises a method for audio/video conferencing. In a preferred embodiment, the method comprises using a dynamic threshold value to determine whether there is speech on a line. One aspect, the method comprises determining a dynamic threshold value based on one or more characteristics of signals received on a port, associating that dynamic threshold value with the port; and comparing one or more characteristics of signals subsequently received on the port to the dynamic threshold value. Signals received over a plurality of ports are summed, but for ports whose signal characteristics have a specified relationship to the dynamic threshold value associated with that port, signals are not contained in the sum.

Abstract: An audio conferencing system comprises an audio conference mixer that receives digitized audio signals and sums a plurality of the digitized audio signals containing speech to provide a summed conference signal. A transcoder receives and transcodes the summed conference signal to provide a transcoded summed signal that is streamed onto the Internet.

Abstract: The present invention comprises a method for audio/video conferencing. In a preferred embodiment, the method comprises using a dynamic threshold value to determine whether there is speech on a line. One aspect, the method comprises determining a dynamic threshold value based on one or more characteristics of signals received on a port, associating that dynamic threshold value with the port; and comparing one or more characteristics of signals subsequently received on the port to the dynamic threshold value. Signals received over a plurality of ports are summed, but for ports whose signal characteristics have a specified relationship to the dynamic threshold value associated with that port, signals are not contained in the sum.

Abstract: An audio conferencing platform includes data bus (e.g., a time division multiplex (TDM) bus), a controller, and an interface circuit that receives audio signals from a plurality of conference participants and provides digitized audio signals in assigned time slots over the TDM bus. The audio conferencing platform also includes a plurality of digital signal processors (DSPs) adapted to communicate on the TDM bus with the interface circuit. At least one of the DSPs sums a plurality of the digitized audio signals associated with conference participants who are speaking, to provide a summed conference signal. This DSP provides the summed conference signal to at least one of the other plurality of DSPs, which removes the digitized audio signal associated with a speaker whose voice is included in the summed conference signal, to provide a customized conference audio signal to each of the speakers.

Abstract: An audio conferencing system comprises an audio conference mixer that receives digitized audio signals and sums a plurality of the digitized audio signals containing speech to provide a summed conference signal. A transcoder receives and transcodes the summed conference signal to provide a transcoded summed signal that is streamed onto the Internet.

Abstract: An audio conferencing platform includes data bus (e.g., a time division multiplex (TDM) bus), a controller, and an interface circuit that receives audio signals from a plurality of conference participants and provides digitized audio signals in assigned time slots over the TDM bus. The audio conferencing platform also includes a plurality of digital signal processors (DSPs) adapted to communicate on the TDM bus with the interface circuit. At least one of the DSPs sums a plurality of the digitized audio signals associated with conference participants who are speaking, to provide a summed conference signal. This DSP provides the summed conference signal to at least one of the other plurality of DSPs, which removes the digitized audio signal associated with a speaker whose voice is included in the summed conference signal, to provide a customized conference audio signal to each of the speakers.

Abstract: The present invention comprises a method for audio/video conferencing. In a preferred embodiment, the method comprises using a dynamic threshold value to determine whether there is speech on a line. One aspect, the method comprises determining a dynamic threshold value based on one or more characteristics of signals received on a port, associating that dynamic threshold value with the port; and comparing one or more characteristics of signals subsequently received on the port to the dynamic threshold value. Signals received over a plurality of ports are summed, but for ports whose signal characteristics have a specified relationship to the dynamic threshold value associated with that port, signals are not contained in the sum.

Abstract: Multiple methods for measuring the COUP-TF system, including: a method to measure the level of COUP-TF by combining antibodies with biological samples and measuring the resultant antibody/COUP-TF complex; the binding of COUP-TF to promoters by combining biological samples with COUP-TF binding oligonucleotides and measuring the resultant complex or gene synthesis; and a method to measure COUP-TF inducable promoters by combining native COUP-TF with nuclear extracts of biological samples and measuring the resultant complexes. The methods when applied to human biological samples can detect diabetes due to COUP-TF or promoter defects. In addition to the methods for measuring the COUP-TF system and associated diseases, there are also the polyclonal and monoclonal antibodies necessary for the methods. These bind to at least one immunoreactive site on COUP-TF. Furthermore, there is a DNA clone containing the genetic coding regions of the COUP-TF protein.