Patents by Inventor William O. Weigle

William O. Weigle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5317013
    Abstract: Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
    Type: Grant
    Filed: September 15, 1992
    Date of Patent: May 31, 1994
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Michael G. Goodman, William O. Weigle
  • Patent number: 5147636
    Abstract: Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substitued guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functioinality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
    Type: Grant
    Filed: August 2, 1990
    Date of Patent: September 15, 1992
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Michael G. Goodman, William O. Weigle
  • Patent number: 4948730
    Abstract: Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged funtionality, while the 8-substituent has an electron withdrawing inductive effector greater than that of hydrogen and contains fewer than about 15 atoms. Anmimal cellular responses are modulated by contacting the cells with a composition of this invention.
    Type: Grant
    Filed: June 6, 1989
    Date of Patent: August 14, 1990
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Michael G. Goodman, William O. Weigle
  • Patent number: 4849411
    Abstract: Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
    Type: Grant
    Filed: February 13, 1987
    Date of Patent: July 18, 1989
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Michael G. Goodman, William O. Weigle
  • Patent number: 4683221
    Abstract: A lymphocyte-activating polypeptide, a composition containing the polypeptide and a method for using the composition are disclosed. The polypeptide contains a sequence of 4 to about 11 residues and corresponds in sequence to the formula:(B).sub.b -Leu-Pro-Pro-Ser-(Y).sub.y.
    Type: Grant
    Filed: January 9, 1986
    Date of Patent: July 28, 1987
    Assignee: Scripps Clinic and Research Foundation
    Inventors: William O. Weigle, Monte O. Hobbs, Edward L. Morgan, Marilyn L. Thoman, Richard A. Houghten
  • Patent number: 4643992
    Abstract: Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
    Type: Grant
    Filed: November 1, 1983
    Date of Patent: February 17, 1987
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Michael G. Goodman, William O. Weigle
  • Patent number: 4539205
    Abstract: Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
    Type: Grant
    Filed: November 9, 1982
    Date of Patent: September 3, 1985
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Michael G. Goodman, William O. Weigle
  • Patent number: 4415493
    Abstract: A class of 23 or 24 amino acid peptides available by chemical synthesis or by enzymatic and chemical cleavage of IgG is described. The compounds are useful in modulating the immune response.
    Type: Grant
    Filed: May 11, 1982
    Date of Patent: November 15, 1983
    Assignee: Scripps Clinic and Research Foundation
    Inventors: William O. Weigle, Edward L. Morgan