Patents by Inventor William Olson

William Olson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12280124
    Abstract: Described herein are protein-drug conjugates and compositions thereof that are useful, for example, for targeting glucagon-like peptide 1 receptor (GLP1R). In certain embodiments, provided are peptidomimetic payloads and linker-payloads and methods of making same. More specifically, GLP1 peptidomimetics, antibody-drug conjugates, and compositions which comprise anti-GLP1R antibodies and GLP1 peptidomimetic payloads and methods of treating GLP1R-associated conditions are provided.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: April 22, 2025
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Amy Han, Haruka Okamoto, William Olson
  • Publication number: 20250122307
    Abstract: The present invention provides antibodies that bind to cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that specifically bind to CTLA-4. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing CTLA-4 activity, thus providing a means of activating T-cells and/or for treating a disease or disorder such as cancer or viral infection.
    Type: Application
    Filed: May 20, 2024
    Publication date: April 17, 2025
    Inventors: Aynur Hermann, Ella IOFFE, Elena BUROVA, Gavin THURSTON, William OLSON
  • Publication number: 20250116301
    Abstract: A disc pack includes stacked disc plates defining a first side and second side of the disc pack. Bolt holes extend through the sides of the disc pack and define a bolt circle. Bushings extend through the bolt holes. Each bushing includes a head at a first end bearing against the first side of the disc pack and a second end that extends axially outside the bolt hole. A washer surrounds at least a portion of the second end and bears against the second side of the disc pack to hold the disc plates together. The disc pack is configured to increase from a first diameter defined by the bolt circle to a second diameter defined by the bolt circle that is at least 0.37% greater than the first diameter when the disc pack is pre-stretched.
    Type: Application
    Filed: October 5, 2023
    Publication date: April 10, 2025
    Applicant: PSC Couplings, LLC
    Inventors: David William Olson, Matthew Joseph DeFord
  • Patent number: 12251440
    Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).
    Type: Grant
    Filed: June 29, 2023
    Date of Patent: March 18, 2025
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Robert Babb, Alina Baum, Gang Chen, Cindy Gerson, Johanna Hansen, Tammy Huang, Christos Kyratsous, Wen-Yi Lee, Marine Malbec, Andrew Murphy, William Olson, Neil Stahl, George D. Yancopoulos
  • Publication number: 20250072928
    Abstract: An apparatus comprises a body assembly and a shaft extending distally therefrom. The shaft defines a longitudinal axis. The apparatus further comprises an acoustic waveguide and an articulation section coupled with the shaft. A portion of the articulation section encompasses a flexible portion of the waveguide. The articulation section further comprises first member and a second member that is longitudinally translatable relative to the first member. The apparatus further comprises an end effector including an ultrasonic blade in acoustic communication with the waveguide. A distal portion the ultrasonic blade is disposed in a first direction away from the longitudinal axis at a bend angle. The end effector also includes a clamp arm that is coupled with the first member and the second member, and an articulation drive assembly operable to drive articulation of the articulation section to thereby deflect the end effector from the longitudinal axis in the first direction.
    Type: Application
    Filed: November 20, 2024
    Publication date: March 6, 2025
    Inventors: Foster B. Stulen, William A. Olson, William B. Weisenburgh, II
  • Publication number: 20250064913
    Abstract: The present invention provides antigen-binding proteins that specifically bind to an HLA-displayed human papillomavirus (HPV) peptide, and therapeutic and diagnostic methods of using those binding proteins.
    Type: Application
    Filed: September 11, 2024
    Publication date: February 27, 2025
    Inventors: Kevin A. Bray, Frank Delfino, Matthew C. Franklin, Elena S. Garnova, Jessica Kirshner, Douglas MacDonald, William Olson, Gavin Thurston
  • Patent number: 12209180
    Abstract: Provided herein are compounds or payloads, linker-payloads, antibody-drug conjugates, and compositions, and methods for the treatment of diseases and disorders associated with the liver X receptor, including bis-octahydrophenanthrene carboxamides and protein (e.g., antibody) drug conjugates thereof.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: January 28, 2025
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Jesper A. Gromada, Viktoria Gusarova, Amy Han, Sokol Haxhinasto, Andrew J. Murphy, William Olson, Matthew Sleeman
  • Publication number: 20250011442
    Abstract: The present invention provides antibodies and antigen-binding fragments (e.g., human antibodies) that bind specifically to human Interleukin-36 receptor (IL36R). Methods for treating or preventing diseases mediated by IL36R (e.g., skin or colon inflammatory conditions such as palmo-plantar pustular psoriasis, palmoplantar pustulosis, generalized pustular psoriasis, ulcerative colitis or IBD) using the antibodies and fragments are also provided along with methods of making the antibodies and fragments.
    Type: Application
    Filed: July 1, 2024
    Publication date: January 9, 2025
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Jeanette FAIRHURST, Elena GARNOVA, William OLSON, Sokol HAXHINASTO
  • Patent number: 12178464
    Abstract: An apparatus comprises a body assembly and a shaft extending distally therefrom. The shaft defines a longitudinal axis. The apparatus further comprises an acoustic waveguide and an articulation section coupled with the shaft. A portion of the articulation section encompasses a flexible portion of the waveguide. The articulation section further comprises first member and a second member that is longitudinally translatable relative to the first member. The apparatus further comprises an end effector including an ultrasonic blade in acoustic communication with the waveguide. A distal portion the ultrasonic blade is disposed in a first direction away from the longitudinal axis at a bend angle. The end effector also includes a clamp arm that is coupled with the first member and the second member, and an articulation drive assembly operable to drive articulation of the articulation section to thereby deflect the end effector from the longitudinal axis in the first direction.
    Type: Grant
    Filed: May 5, 2023
    Date of Patent: December 31, 2024
    Assignee: Cilag GmbH International
    Inventors: Foster B. Stulen, William A. Olson, William B. Weisenburgh, II
  • Publication number: 20240409637
    Abstract: Anti-CD8 antibodies, radiolabeled anti-CD8 antibodies, fluorescently labeled anti-CD8 antibodies and their use in imaging are provided herein. Included are methods of detecting the presence of CD8 proteins in a subject or sample.
    Type: Application
    Filed: July 23, 2024
    Publication date: December 12, 2024
    Inventors: Jason T. Giurleo, Dangshe Ma, William Olson, Gavin Thurston, Richard Tavare
  • Patent number: 12152067
    Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to Ebola virus glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing Ebola virus activity, thus providing a means of treating or preventing Ebola virus infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the Ebola virus for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.
    Type: Grant
    Filed: November 9, 2022
    Date of Patent: November 26, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Christos Kyratsous, William Olson, Peter Mason, Neil Stahl
  • Patent number: 12144864
    Abstract: Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: November 19, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Amy Han, Marcus Kelly, William Olson
  • Publication number: 20240360153
    Abstract: Compounds and pharmaceutical compositions for use in the treatment of a disorder or disease mediated by the mTOR pathway through more selective binding to FKBP12 of the group of FK506 binding proteins (FKBPs) are disclosed. With an unusual pharmacokinetic profile and an enhanced pharmacodynamic selectivity among target FKBPs, those compounds are useful for the treatment of age- or aging-related diseases, diabetes, cancers, as well as inflammation-associated disorders.
    Type: Application
    Filed: April 5, 2024
    Publication date: October 31, 2024
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: David Glass, Joseph P. Vacca, Tea Shavlakadze, Chester A. Metcalf, III, William Olson
  • Patent number: 12115216
    Abstract: The present invention provides antigen-binding proteins that specifically bind to an HLA-displayed human papillomavirus (HPV) peptide, and therapeutic and diagnostic methods of using those binding proteins.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: October 15, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kevin A. Bray, Frank Delfino, Matthew C. Franklin, Elena S. Garnova, Jessica Kirshner, Douglas MacDonald, William Olson, Gavin Thurston
  • Publication number: 20240335572
    Abstract: Radiolabeled anti-PD-L1 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of PD-L1 proteins in a patient or sample.
    Type: Application
    Filed: June 21, 2024
    Publication date: October 10, 2024
    Inventors: Marcus Kelly, Dangshe Ma, William Olson, Gavin Thurston
  • Publication number: 20240327501
    Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to Ebola virus glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing Ebola virus activity, thus providing a means of treating or preventing Ebola virus infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the Ebola virus for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.
    Type: Application
    Filed: November 9, 2022
    Publication date: October 3, 2024
    Inventors: Christos Kyratsous, William Olson, Peter Mason, Neil Stahl
  • Patent number: 12103960
    Abstract: Vascular endothelial growth factor (VEGF) traps and VEGF mini-traps that include VEGF receptor Ig-like domains, fused to a multimerizing component, are disclosed. The VEGF traps and VEGF mini-traps bind to VEGF and block its interaction with the VEGF receptor. Such molecules are useful for treating angiogenic eye disorders (e.g., age-related macular degeneration), cancer and for other undesired angiogenesis.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: October 1, 2024
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: William Olson, Joel Martin, Neil Stahl, Jee Kim
  • Publication number: 20240307563
    Abstract: Radiolabeled anti-MET antibodies and MET×MET bispecific antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of MET proteins in a subject or sample and methods of monitoring efficacy of treatment of a Met expressing tumor.
    Type: Application
    Filed: December 29, 2023
    Publication date: September 19, 2024
    Inventors: Marcus Kelly, Dangshe Ma, William Olson
  • Patent number: 12077587
    Abstract: Anti-CD8 antibodies, radiolabeled anti-CD8 antibodies, fluorescently labeled anti-CD8 antibodies and their use in imaging are provided herein. Included are methods of detecting the presence of CD8 proteins in a subject or sample.
    Type: Grant
    Filed: October 26, 2022
    Date of Patent: September 3, 2024
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Jason T. Giurleo, Dangshe Ma, William Olson, Gavin Thurston, Richard Tavare
  • Publication number: 20240277844
    Abstract: In certain aspects, provided herein are compositions and methods for treating cancer. The methods of the present disclosure comprise administering to a subject in need thereof a NK cell expressing a CAR in combination with an antigen-binding molecule that binds to a tumor antigen, wherein the CAR-NK cell targets tumor cells through binding to the antigen-binding molecule.
    Type: Application
    Filed: February 16, 2024
    Publication date: August 22, 2024
    Inventors: Nicolin Bloch, Erica Ullman, Aynur Hermann, William Olson, George D. Yancopoulos