Abstract: The present invention provides monoclonal antibodies that bind to the complement factor 5 (C5) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to C5 protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing C5 activity, thus providing a means of treating or preventing a C5-related disease or disorder in humans. In some embodiments, the invention provides for an anti-C5 antibody that has improved pharmacokinetic and pharmacodynamic properties, e.g., a half-life of more than 10 days.

Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to ZIKV glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing ZIKV activity, thus providing a means of treating or preventing ZIKV infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the ZIKV for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.

Abstract: Methods, systems, and computer programs are presented for capturing color images of items for a machine-learning model. In one method, a request, for adding an item to be visually recognized during sales transactions, is detected at a checkout apparatus. Further, the method includes capturing and storing a color image, by each of one or more cameras of the checkout apparatus, of an examination space when the item is present. Further, the capturing and storing of color images of the item is repeated at different poses until at a predetermined number of color images of the item are captured. Further, the method includes generating, by a processor of the checkout apparatus, additional images of the item by modifying the captured color images. A machine-learning model for item recognition is built by training a machine-learning tool with the captured images and the additional images.

Abstract: The present invention provides antibodies and antigen-binding fragments (e.g., human E antibodies) that bind specifically to human IL-36 receptor. Methods for treating or preventing diseases mediated by IL36R (e.g., skin or colon inflammatory conditions such as palmo-plantar pustular psoriasis, palmoplantar pustulosis, generalized pustular psoriasis, ulcerative colitis or IBD) using the antibodies and fragments are also provided along with methods of making the antibodies and fragments.

Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to the influenza hemagglutinin (HA) protein, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing influenza virus activity, thus providing a means of treating or preventing influenza infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the influenza HA for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.

Abstract: The present invention provides antibodies that bind to Staphylococcus aureus Hemolysin A toxin, and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Hemolysin A. The antibodies of the invention are useful for inhibiting or neutralizing Hemolysin A activity, thus providing a means of preventing or treating a Hemolysin A-related disease or disorder such as S. aureus infection. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of a S. aureus infection.

Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to Ebola virus glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing Ebola virus activity, thus providing a means of treating or preventing Ebola virus infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the Ebola virus for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.

Abstract: Provided herein are antibodies and antigen-binding fragments that bind MSR1 and methods of use thereof. According to certain embodiments, the antibodies bind human MSR1 with high affinity. In certain embodiments, the antibodies bind MSR1 without blocking, or blocking less than 90%, of modified LDL binding to MSR1. In some embodiments, the antibodies bind cell surface expressed-MSR1 and are internalized. The antibodies of the invention may be fully human antibodies. The invention includes anti-MSR1 antibodies, or antigen-binding fragments thereof, conjugated to drugs or therapeutic compounds.

Abstract: A coupling assembly includes a body member and at least one end member attached to the body member. At least one connection arrangement is situated between the body member and the at least one end member, respectively. The at least one connection arrangement includes a plurality of bushings. A plurality of fasteners are each respectively received by the plurality of bushings to fasten the body member to the at least one end member. Each one of the plurality of bushings are rotationally fixed about their center longitudinal axes by the at least one connection arrangement.

Abstract: An ultrasonic surgical device is disclosed including a surgical tool including a proximal transducer mounting portion defining a surface, a distal end effector end, and a waveguide disposed therebetween, the waveguide extending along a longitudinal axis. The ultrasonic surgical device further includes a transducer is in mechanical communication with the surface of the transducer mounting portion. The transducer is configured to operate in a D31 mode with respect to the longitudinal axis of the waveguide.

Abstract: The present invention provides antibodies that bind to Staphylococcus aureus Hemolysin A toxin, and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Hemolysin A. The antibodies of the invention are useful for inhibiting or neutralizing Hemolysin A activity, thus providing a means of preventing or treating a Hemolysin A-related disease or disorder such as S. aureus infection. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of a S. aureus infection.

Abstract: Various embodiments described herein are directed to ultrasonic blades. For example, an ultrasonic blade may comprise a proximally positioned straight section extending along a longitudinal axis and a distally positioned curved section coupled to the straight section and curved away from the longitudinal axis. The curved section may define a radius of curvature and subtend a first angle. A point of tangency between the curved section and the straight section may be positioned at either a node of the ultrasonic blade or an anti-node of the ultrasonic blade.

Abstract: Disclosed is an ultrasonic medical device that may include a surgical tool having a proximal end, an end effector, and a waveguide between them, a first transducer in mechanical communication with a first face of the surgical tool, and a second transducer in mechanical communication with an opposing face of the surgical tool, opposite the first transducer. The first transducer and the second transducer are configured to operate in a D31 mode with respect to the waveguide of the surgical tool. Another aspect comprises a method of fabricating the ultrasonic medical device, in which the surgical tool is machined from a portion of a flat metal stock so that the surgical tool has a longitudinal axis oriented at an angle with respect to a grain direction of the flat metal stock thereby optimizing an operational characteristic of the surgical tool.

Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to ZIKV glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing ZIKV activity, thus providing a means of treating or preventing ZIKV infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the ZIKV for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.

Abstract: A hydraulic system for a mobile work vehicle is configurable in a hybrid mode and a hydrostatic mode. The hydraulic system includes a pump/motor, a propel circuit, a pump, a hydraulic accumulator, and an accessory circuit. The pump/motor is adapted to exchange power with a drive train of the mobile work vehicle. The propel circuit is adapted to exchange hydraulic fluid power with the pump/motor. The pump is adapted to transfer power from a prime mover of the mobile work vehicle to the propel circuit. The hydraulic accumulator is adapted to exchange hydraulic fluid power via an accumulator isolation valve with the propel circuit when the hydraulic system is configured in the hybrid mode. The accessory circuit is adapted to receive hydraulic fluid power from the hydraulic accumulator, at least when the hydraulic system is configured in the hydrostatic mode and the accumulator isolation valve is closed.

Abstract: A method of propelling a vehicle with a hybrid mode and a hydrostatic mode includes determining if a current propulsion mode is hybrid and if a selected mode is hydrostatic. A first transition mode is entered if the selected mode is hydrostatic and the current mode is hybrid. An engine-pump displacement target is set in the first transition mode. The method may include determining if the current mode is hybrid, hydrostatic, or a no-propulsion mode and if the selected mode is hybrid, hydrostatic, or no-propulsion. The engine-pump displacement target may be matched to a system consumption and an accumulator isolation valve closed when an engine-pump output matches the system consumption in the first transition mode. The method may include entering a second transition mode if the selected mode is hybrid and the current mode is hydrostatic.

Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to the influenza hemagglutinin (HA) protein, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing influenza virus activity, thus providing a means of treating or preventing influenza infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the influenza HA for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.

Abstract: A surgical apparatus comprises a body, an ultrasonic transducer, a shaft, and an end effector. The ultrasonic transducer is operable to convert electrical power into ultrasonic vibrations. The shaft couples the end effector and the body together. The end effector comprises an ultrasonic blade in acoustic communication with the ultrasonic transducer. The ultrasonic blade includes a recess region having a plurality of recesses. The recess region is tapered such that the cross-sectional area of the recess region decreases along the length of the recess region. The ultrasonic blade is also curved such that a central longitudinal axis of the ultrasonic blade extends along a curved path. A reference circuit is used to account for voltage drops of unknown values during operation of the surgical apparatus.

Abstract: Methods, systems, and computer programs are presented for providing a feedback loop to improve object image-based recognition based on transaction data. In one method, instructions are received defining items to be visually recognized by a terminal. For each item, a check is made to determine if item image information is in a global database or if it is a new item. The global database includes item images captured during transactions performed at several terminals. For each item in the global database, item image information is downloaded from the global database. For new items, terminal cameras capture pose images for several poses of the new items, each camera taking an image for each pose. A machine-learning program is trained with the downloaded image information and the pose images, where the machine-learning program performs image-based recognition of the items that are presented at the terminal, based on images captured by the cameras.

Abstract: Methods, systems, and computer programs are presented for capturing color images of items for a machine-learning model. In one method, a request, for adding an item to be visually recognized during sales transactions, is detected at a checkout apparatus. Further, the method includes capturing and storing a color image, by each of one or more cameras of the checkout apparatus, of an examination space when the item is present. Further, the capturing and storing of color images of the item is repeated at different poses until at a predetermined number of color images of the item are captured. Further, the method includes generating, by a processor of the checkout apparatus, additional images of the item by modifying the captured color images. A machine-learning model for item recognition is built by training a machine-learning tool with the captured images and the additional images.