Abstract: The invention relates to the use of pharmaceutical compositions of the SGLT2 inhibitor, remogliflozin etabonate, to treat primary sclerosing cholangitis (PSC). Methods and compositions associated with the invention can improve or maintain clinical outcomes of PSC symptoms, such as ascites accumulation, hepatic encephalopathy, development of varices, jaundice, variceal bleeding, cholangiocarcinoma, hepatocellular carcinoma, evidence of cirrhosis, and colorectal cancer.

Abstract: A flow constraint material consists essentially of degradable particles, where at least 50% by volume of the degradable particles have an average particle size of about 1 millimeters (mm) to about 6 mm.

Abstract: Methods and systems for delivering well stimulation materials to a wellbore using a high-pressure delivery manifold are provided. In some embodiments, the methods of the present disclosure include: providing a pressurizable delivery manifold at a well site, wherein the pressurizable delivery manifold is continuously equalized with a piping system; providing a pressurized treatment fluid to the pressurizable delivery manifold; releasing one or more well stimulation materials into the pressurized treatment fluid to create a payload delivery treatment fluid; and injecting the payload delivery treatment fluid into at least a portion of a subterranean formation.

Abstract: Aspects of the subject technology relate to systems and methods for controlling a hydraulic fracturing job. One or more perforations to create during a fracturing stage of a fracturing job at one or more corresponding perforation sites in a wellbore can be identified. The one or more perforations can be formed through one or more perforation devices disposed in the wellbore. Specifically, the one or more perforation devices can be selectively activated from a surface of the wellbore through a well intervention-less technique to selectively form the one or more perforations during the fracturing stage. Further, a volume of fracturing fluid can be pumped into the wellbore during the fracturing stage to form one or more first fractures in a surrounding formation through the one or more perforations.

Abstract: A razor blade including: a substrate having a tip portion including a tip region, a blade body including a base, and first and second outer sides disposed opposite a split line of the substrate that converge at a tip; and first and second coatings disposed substantially on the first and second outer sides, respectively. Also provided is a method of coating the razor blade, including: applying a first coating to at least a portion of the first outer side; and applying a second coating to at least a portion of the second outer side. The first and second coatings each extend from the tip region toward the base and are substantially different, as compared to each other. One or both of the first and second coatings comprise a plurality of layers of material.

Abstract: A system includes a headset to capture sound and a visual signal of a local area including one or more sound sources. The system determines a strength of the audio signal and a portion of the visual signal associated with the audio signal, compares the strengths, selects the weaker signal, and augments the weaker signal. The headset accordingly presents augmented audio-visual content to a user, thereby enhancing the user's perception of the weak signal.

Abstract: The invention relates to the use of pharmaceutical compositions of the SGLT2 inhibitor, remogliflozin etabonate, to treat primary sclerosing cholangitis (PSC). Methods and compositions associated with the invention can improve or maintain clinical outcomes of PSC symptoms, such as ascites accumulation, hepatic encephalopathy, development of varices, jaundice, variceal bleeding, cholangiocarcinoma, hepatocellular carcinoma, evidence of cirrhosis, and colorectal cancer.

Abstract: A razor cartridge is provided comprising: a housing and a blade assembly mounted to the housing. The blade assembly may comprise at least one razor blade defined by a substrate comprising a first portion and a second portion. The first portion may comprise first and second outer surfaces. The second portion may comprise first and second sections separated by a split line. The first section may comprise a first facet and an end facet. The second section may comprise an end facet. The end facets of the first and second sections may converge at a tip to define a cutting edge. A shoulder may be positioned between the first facet and the end facet of the first section and define a skin-contacting surface.

Abstract: A razor blade including: a substrate having a tip portion including a tip region, a blade body including a base, and first and second outer sides disposed opposite a split line of the substrate that converge at a tip; and first and second coatings disposed substantially on the first and second outer sides, respectively. Also provided is a method of coating the razor blade, including: applying a first coating to at least a portion of the first outer side; and applying a second coating to at least a portion of the second outer side. The first and second coatings each extend from the tip region toward the base and are substantially different, as compared to each other.

Abstract: A razor blade is provided comprising a substrate comprising a first portion and a second portion. The first portion may comprise first and second generally parallel outer surfaces. The second portion may comprise first and second sections separated by a split line. The first section may comprise a first facet extending directly from the first outer surface of the first portion and an end facet extending directly from the first facet. The second section may comprise an end facet. The end facets of the first and second sections may converge at a tip to define a cutting edge. The split line may pass through the tip and is generally parallel with and extends between the first and second outer surfaces of the first portion.

Abstract: A razor blade including: a substrate having a tip portion including a tip region, a blade body including a base, and first and second outer sides disposed opposite a split line of the substrate, in which the first and second outer sides converge at a tip, the first outer side comprises a first coating disposed substantially thereon and extending from the tip region toward the base, and a first portion of the second outer side is substantially free of any coating, the first portion extending from the tip region toward the base or being spaced apart from the tip region and the base. Also provided is a method of coating the razor blade.

Abstract: A system can include a position sensor configured to output position data of a HWD. The system can include one or more processors configured to identify a first head angle of the HWD using the position sensor, generate an audio signal using the first head angle, identify a second head angle of the HWD using the position sensor, determine an angle error based at least on the first head angle and the second head angle, and apply at least one of a time difference or a level difference to the audio signal based at least on the angle error to adjust the audio signal. The system can include an audio output device configured to output the adjusted audio signal. By adjusting the audio signal using the angle error, the system can correct for long spatial update latencies and reduce the perceptual impact of such latencies for the user.

Abstract: A system includes a headset to capture sound and a visual signal of a local area including one or more sound sources. The system determines a strength of the audio signal and a portion of the visual signal associated with the audio signal, compares the strengths, selects the weaker signal, and augments the weaker signal. The headset accordingly presents augmented audio-visual content to a user, thereby enhancing the user's perception of the weak signal.

Abstract: A system includes a headset to capture sound and a visual signal of a local area including one or more sound sources. The system determines a strength of the audio signal and a portion of the visual signal associated with the audio signal, compares the strengths, selects the weaker signal, and augments the weaker signal. The headset accordingly presents augmented audio-visual content to a user, thereby enhancing the user's perception of the weak signal.

Abstract: Aspects of the subject technology relate to systems, methods, and computer-readable media for controlling a hydraulic fracturing job. Diagnostics data of a hydraulic fracturing completion of a wellbore can be received. A fracture formation model that models formation characteristics of fractures formed through the wellbore into a formation surrounding the wellbore during the hydraulic fracturing completion with respect to surface variables can be accessed. A subsurface objective function of fracture complexity can be selected from a plurality of subsurface objective functions for changing one or more of the formation characteristics of the fractures. The fracture formation model can be applied based on the diagnostics data to determine values of the surface variables for controlling the formation characteristics of the fractures to converge on the subsurface objective function of fracture complexity. As follows, a fracture completion plan can be formed based on the values of the surface variables.

Abstract: Aspects of the subject technology relate to systems and methods for controlling a hydraulic fracturing job. Systems and methods are provided for receiving diagnostics data of a hydraulic fracturing completion of a wellbore, accessing a fracture formation model that models formation characteristics of fractures formed through the wellbore into a formation surrounding the wellbore during the hydraulic fracturing completion with respect to surface variables of the hydraulic fracturing completion, selecting one or more subsurface objective functions from a plurality of subsurface objective functions for changing one or more of the formation characteristics of the fractures, the one or more subsurface objective functions including an objective function for wellbore interference, the objective function for wellbore interference including interference information from a neighboring wellbore, and applying the fracture formation model based on the diagnostics data to determine values of the surface variables.

Abstract: Aspects of the subject technology relate to systems and methods for controlling a hydraulic fracturing job. Systems and methods are provided for receiving diagnostics data of a hydraulic fracturing completion of a wellbore, accessing a fracture formation model that models formation characteristics of fractures formed through the wellbore into a formation surrounding the wellbore during the hydraulic fracture completion with respect to surface variables of the hydraulic fracturing completion, selecting one or more subsurface objective functions from a plurality of subsurface objective functions for changing one or more of the formation characteristics of the fractures, and applying the fracture formation model based on the diagnostics data to determine values of the surface variables for controlling the formation characteristics of the fractures to converge on the one or more subsurface objective functions.

Abstract: Aspects of the subject technology relate to systems and methods for controlling a hydraulic fracturing job.

Abstract: A system creates an audio profile. The audio profile may be stored in a database. For example, the audio profile may be securely stored in a database of a social network and associated with a user account. The audio profile may contain data describing the way in which the specific user hears and interprets sounds. Systems and applications which present sounds to the user may access the audio profile and modify the sounds presented to the user based on the data in the audio profile to enhance the audio experience for the user.

Abstract: An audio system generates customized head-related transfer functions (HRTFs) for a user. The audio system receives an initial set of estimated HRTFs. The initial set of HRTFs may have been estimated using a trained machine learning and computer vision system and pictures of the user's ears. The audio system generates a set of test locations using the initial set of HRTFs. The audio system presents test sounds at each of the initial set of test locations using the initial set of HRTFs. The audio system monitors user responses to the test sounds. The audio system uses the monitored responses to generate a new set of estimated HRTFs and a new set of test locations. The process repeats until a threshold accuracy is achieved or until a set period of time expires. The audio system presents audio content to the user using the customized HRTFs.