Patents by Inventor William P. Dole

William P. Dole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene therapy for critical limb ischemia with wild type or mutant eNOS
    Publication number: 20040120930
    Abstract: The present invention provides novel methods of preventing, diagnosing, and treating Critical Limb Ischemia (CLI), using eNOS polypeptides and polynucleotides to modulate eNOS activity in cells. Wild-type and mutant eNOS polypeptides, and polynucleotides encoding such polypeptides, are provided for use in the methods of the present invention. The eNOS mutant polypeptides of the present invention have at least one mutation corresponding to a site in a functional domain of a mammalian eNOS that is phosphorylated in cells.
    Type: Application
    Filed: August 15, 2003
    Publication date: June 24, 2004
    Applicant: Schering Aktiengesellschaft
    Inventors: William P. Dole, Katalin Kauser, Hu Sheng Qian, Gabor Rubanyi