Abstract: Provided are compounds of the formula I and pharmaceutically acceptable salts, solvates, and hydrates thereof, for use in treating or suppressing a SARS-CoV-2 infection in a subject. A novel dosing regimen for administration of the disclosed compounds is also provided comprising administering at least one loading dose and at least one maintenance dose of the disclosed compound. The compounds of the disclosure are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with the dosing regimen described.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are oral dosage forms comprising such a compound, salt, or prodrug. Also disclosed are methods of using the compounds, salts, and prodrugs, and oral dosage forms thereof, in the treatment or prevention of a disease or condition characterized by aberrant complement system activity (e.g., paroxysmal nocturnal hemoglobinuria).

Abstract: A turbo fan engine includes a housing that supports a compressor section. At least one compressor hub is within the compressor section. A compressor shaft is arranged in the compressor section. An epicyclic gear train is coupled to the compressor shaft. At least one compressor hub and the compressor shaft are coupled at a common attachment point. The epicyclic gear train includes a carrier. A sun gear and intermediate gears are arranged about and intermeshing with the sun gear. The intermediate gears are supported by the carrier. A baffle is supported relative to the carrier and includes a lubrication passage near at least one of the sun gear and intermediate gears for directing a lubricant on at least one of the sun gear and the intermediate gears.

Abstract: A turbo fan engine includes a housing that supports a compressor section. At least one compressor hub is within the compressor section. A compressor shaft is arranged in the compressor section. An epicyclic gear train is coupled to the compressor shaft. At least one compressor hub and the compressor shaft are coupled at a common attachment point. The epicyclic gear train includes a carrier. A sun gear and intermediate gears are arranged about and intermeshing with the sun gear. The intermediate gears are supported by the carrier. A baffle is supported relative to the carrier and includes a lubrication passage near at least one of the sun gear and intermediate gears for directing a lubricant on at least one of the sun gear and the intermediate gears.

Abstract: Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.

Abstract: Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.

Abstract: Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.