Abstract: A mouthpiece for smoking instruments which is structured to be anatomically correct, in that it is structurally compatible with the mouth parts of a user when the mouthpiece is situated in the user's mouth to one side thereof. The mouthpiece is a laterally asymmetrical structure which conforms to the shape of the side of the mouth. The tip is acutely angled in relation to the mouthpiece axis which lateral asymmetry locates the tip so that it does not interferingly affront the tongue and cheek thereby increasing comfort and teeth feel and the port of the tip is directed toward the tongue cavity thereby making inhalation easier and more efficient. The mouthpiece is vertically symmetrical so that by simply inverting the mouthpiece, it can be placed comfortably at either side of a user's mouth. The mouthpiece is preferred to include a groove adjacent the end for interfacingly receiving with the tips of the smoker's teeth.