Patents by Inventor William Patrick Waters
William Patrick Waters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11142758Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-celluar fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.Type: GrantFiled: March 20, 2017Date of Patent: October 12, 2021Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Erik Leeming Kvam, John Richard Nelson, Gregory Andrew Grossmann, Ryan Charles Heller, Erin Jean Finehout, Christopher Michael Puleo, William Patrick Waters
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Patent number: 10088399Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: GrantFiled: May 1, 2015Date of Patent: October 2, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Publication number: 20170211059Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-celluar fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.Type: ApplicationFiled: March 20, 2017Publication date: July 27, 2017Inventors: Erik Leeming Kvam, John Richard Nelson, Gregory Andrew GROSSMANN, Ryan Charles Heller, Erin Jean Finehout, Christopher Michael Puleo, William Patrick Waters
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Patent number: 9644232Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-cellular fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.Type: GrantFiled: July 26, 2013Date of Patent: May 9, 2017Assignee: General Electric CompanyInventors: Erik Leeming Kvam, John Richard Nelson, Gregory Andrew Grossmann, Ryan Charles Heller, Erin Jean Finehout, Christopher Michael Puleo, William Patrick Waters
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Publication number: 20150233803Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: ApplicationFiled: May 1, 2015Publication date: August 20, 2015Inventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Patent number: 9034280Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: GrantFiled: December 16, 2009Date of Patent: May 19, 2015Assignee: GENERAL ELECTRIC CORPORATIONInventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Patent number: 9012060Abstract: In accordance with an embodiment of the invention, an assembly of tubular cell insulator casings is provided. The assembly includes a plurality of tubular cell insulator casings, wherein each cell insulator casing is open at a top end and configured to surround at least one of a plurality of electrically interconnected electrochemical cells, wherein said plurality of tubular cell insulator casings comprises a monolithic unit. The battery pack also includes a plurality of insulator plugs and a sump plate configured to support said plurality of insulator plugs.Type: GrantFiled: December 26, 2012Date of Patent: April 21, 2015Assignee: General Electric CompanyInventors: John Raymond Krahn, Kristopher John Frutschy, Narayan Subramanian, William Patrick Waters, Daniel Qi Tan, William Hubert Schank
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Publication number: 20150031035Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-cellular fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.Type: ApplicationFiled: July 26, 2013Publication date: January 29, 2015Applicant: General Electric CompanyInventors: Erik Leeming Kvam, John Richard Nelson, Gregory Andrew Grossmann, Ryan Charles Heller, Erin Jean Finehout, Christopher Michael Puleo, William Patrick Waters
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Patent number: 8916285Abstract: A cell module and modular cell tray apparatus for a modular electrochemical device that are more easily manufactured and serviced. A cell module is provided having a plurality of electrochemical cells. The cell module includes an electrically conductive carrier element having a plurality of apertures, wherein each aperture is configured to accept a top portion of an electrode body of an electrochemical cell. A modular cell tray apparatus is provided having a plurality of the cell modules. The cell tray apparatus includes an electrically insulating tray having rows of cell receptacles to accept the cell modules. A modular electrochemical device is provided having a plurality of the cell tray apparatuses. The modular electrochemical device includes a plurality of electrical connectors configured to electrically connect the cell modules within a cell tray apparatus, and to electrically connect the cell tray apparatuses to each other.Type: GrantFiled: December 28, 2011Date of Patent: December 23, 2014Assignee: General Electric CompanyInventors: Kristopher John Frutschy, Reza Sarrafi-Nour, Stefan Rakuff, Sandor Istvan Hollo, Narayan Subramanian, William Patrick Waters, James Thorpe Browell, Kanthi Latha Bhamidipati
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Publication number: 20140178742Abstract: In accordance with an embodiment of the invention, an assembly of tubular cell insulator casings is provided. The assembly includes a plurality of tubular cell insulator casings, wherein each cell insulator casing is open at a top end and configured to surround at least one of a plurality of electrically interconnected electrochemical cells, wherein said plurality of tubular cell insulator casings comprises a monolithic unit. The battery pack also includes a plurality of insulator plugs and a sump plate configured to support said plurality of insulator plugs.Type: ApplicationFiled: December 26, 2012Publication date: June 26, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: John Raymond Krahn, Kristopher John Frutschy, Narayan Subramanian, William Patrick Waters, Daniel Qi Tan, William Hubert Schank
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Publication number: 20130171507Abstract: A cell module and modular cell tray apparatus for a modular electrochemical device that are more easily manufactured and serviced. A cell module is provided having a plurality of electrochemical cells. The cell module includes an electrically conductive carrier element having a plurality of apertures, wherein each aperture is configured to accept a top portion of an electrode body of an electrochemical cell. A modular cell tray apparatus is provided having a plurality of the cell modules. The cell tray apparatus includes an electrically insulating tray having rows of cell receptacles to accept the cell modules. A modular electrochemical device is provided having a plurality of the cell tray apparatuses. The modular electrochemical device includes a plurality of electrical connectors configured to electrically connect the cell modules within a cell tray apparatus, and to electrically connect the cell tray apparatuses to each other.Type: ApplicationFiled: December 28, 2011Publication date: July 4, 2013Inventors: Kristopher John Frutschy, Reza Sarrafi-Nour, Stefan Rakuff, Sandor Istvan Hollo, Narayan Subramanian, William Patrick Waters, James Thorpe Browell, Kanthi Latha Bhamidipati
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Publication number: 20110143427Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: ApplicationFiled: December 16, 2009Publication date: June 16, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters