Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A shell assembly configured for holding one or more weighted articles includes an outer shell having an outer surface and an inner surface defining a cavity configured for receiving the article(s) therein, with an opening providing access to the cavity, a closure configured for selectively opening and closing the opening, and a securing structure configured for securing the article(s) within the cavity to limit movement of the article(s). The securing structure includes a plurality of adjustable straps each connected to the inner surface of the outer shell at a first securing point and a second securing point on opposite sides of the opening. Each of the straps is adjustable with respect to the outer shell to increase or decrease an effective length of the respective strap between the respective securing points, to increase or decrease a distance between the respective securing points and thereby constrict or expand the outer shell.

Abstract: Compact inertial device for muscle training, consisting of a pulling body (1) and a drive rope (2). The pulling body (1) in turn comprises a rotating main shaft (4), a reel (8) mounted on the main shaft (4), an inertia element (6) linked solidly to one end of the main shaft (4) for accumulation of kinetic energy from the rotation of the main shaft (4), and a planetary gear (5), which in turn comprises a central gear mounted on the main shaft (4), for multiplication of the transmission speed from the main shaft (4) driven by the reel (8) to the inertia element (6). In its preferred embodiment, the spool (8) is a conical spool with a smaller diameter sector to which one end of the rope (2) is solidly attached.

Abstract: The improved plumbing P-trap is a plumbing fixture. The improved plumbing P-trap attaches the drain of a sink to a DWV. The improved plumbing P-trap transports gray water into the DWV from the sink. The improved plumbing P-trap comprises a modified P-trap, a second clean out plug, and a snake guide. The modified P-trap transports gray water from the sink drain to the DWV. The second clean out plug is the modification to the modified P-trap that provides access to the DWV side of the modified P-trap. The second clean out plug is intended for use with a plumbing snake. The snake guide: 1) opens the second clean out plug; and, 2) attaches to the second clean out plug to guide the plumbing snake into the DWV.

Abstract: A universal offset lawn mower towing device includes a hitch engagement unit having a first elongated shaft with an opening along one end. An offset adjustment unit having a second elongated shaft member is slidingly positioned within the first elongated shaft, and further includes a semi-circular plate with a plurality of alignment apertures. A pair of mower attachment arms extend outward from the semi-circular plate and include mower attachment nuts along their distal ends. A safety tether includes an elongated steel cable that runs the length of the device, and connects the safety handle of the upright mower to the riding mower.

Abstract: A universal offset lawn mower towing device includes a hitch engagement unit having a first elongated shaft with an opening along one end. An offset adjustment unit having a second elongated shaft member is slidingly positioned within the first elongated shaft, and further includes a semi-circular plate with a plurality of alignment apertures. A pair of mower attachment arms extend outward from the semi-circular plate and include mower attachment nuts along their distal ends. A safety tether includes an elongated steel cable that runs the length of the device, and connects the safety handle of the upright mower to the riding mower.

Abstract: Certain embodiments of the present invention include a system and methods for providing a video image display technology with separate video perspective displays. Each perspective display may be tailored and adapted in real-time to the differing roles of each user, e.g., one or more medical professionals of a surgical team. As an example, one video perspective display may be a panoramic perspective display for a primary surgeon and a second video perspective may be a detailed perspective display for the surgical assistant.

Abstract: It is equipped with two openings (1, 10) and has an external surface of several stretches of reduced thickness and consistent in each one of its radial cross-sections. It is of flexible material and comprises a bumpy first stretch (5) defined by parallel perimeter grooves (14). It can be used on tools, especially screwdrivers, and facilitates the coupling of the screw head to the screwdriver through one of its openings or optionally through the magnetic attraction exerted by a built-in magnet (8). Likewise, it can be applied to writing tools, such as propelling pencils or ballpoint pens.

Abstract: Certain embodiments of the present invention include a system and methods for providing a video image display technology with separate video perspective displays. Each perspective display may be tailored and adapted in real-time to the differing roles of each user, e.g., one or more medical professionals of a surgical team. As an example, one video perspective display may be a panoramic perspective display for a primary surgeon and a second video perspective may be a detailed perspective display for the surgical assistant.

Abstract: It is equipped with two openings (1, 10) and has an external surface of several stretches of reduced thickness and consistent in each one of its radial cross-sections. It is of flexible material and comprises a bumpy first stretch (5) defined by parallel perimeter grooves (14). It can be used on tools, especially screwdrivers, and facilitates the coupling of the screw head to the screwdriver through one of its openings or optionally through the magnetic attraction exerted by a built-in magnet (8). Likewise, it can be applied to writing tools, such as propelling pencils or ballpoint pens.

Abstract: Embodiments of the present invention provide methods of and apparatuses for coordinating patient communication in a professional office. An example method comprises providing the patient with a mobile computing device programmed to accommodate entering demographic information, consent forms and medical history. The mobile device can be programmed to allow users to sign appropriate forms, such as those required for HIPAA purposes. The device can be checked out to the patient and, if desired, appropriate physical security measures can be employed. A patient can complete the forms using the input modes allowed by the device, such as touch input or by stylus. Program-based input controls can help the user enter appropriate information. In some example embodiments, the mobile device communicates with office data systems. Declined records can be returned to the user, for example, with areas to be addressed highlighted.

Abstract: A composition is disclosed which comprises an aryl perfluoropolyether, optionally a halogenated oil, and further optionally a thickening agent. The composition can be used as a lubricant itself or as an additive to an oil or grease lubricant and can withstand temperatures higher than 300° C. without decomposition. The halogenated oil can be a perfluoropolyether, a fluorosilicone, a polytrifluorochloroethylene, or combinations of two or more thereof. The thickening agent can be finely divided silica, boron nitride, clay, soap, poly(tetrafluoroethylene), clay, talc, silica, titanium dioxide, polydimethylsiloxane, polyurea, polyurethane, or combinations of two or more thereof.

Abstract: A composition is disclosed which comprises an aryl perfluoropolyether, optionally a halogenated oil, and further optionally a thickening agent. The composition can be used as a lubricant itself or as an additive to an oil or grease lubricant and can withstand temperatures higher than 300° C. without decomposition. The halogenated oil can be a perfluoropolyether, a fluorosilicone, a polytrifluorochloroethylene, or combinations of two or more thereof. The thickening agent can be finely divided silica, boron nitride, clay, soap, poly(tetrafluoroethylene), clay, talc, silica, titanium dioxide, polydimethylsiloxane, polyurea, polyurethane, or combinations of two or more thereof.

Abstract: A composition is disclosed which comprises an aryl perfluoropolyether, optionally a halogenated oil, and further optionally a thickening agent. The composition can be used as a lubricant itself or as an additive to an oil or grease lubricant and can withstand temperatures higher than 300° C. without decomposition. The halogenated oil can be a perfluoropolyether, a fluorosilicone, a polytrifluorochloroethylene, or combinations of two or more thereof. The thickening agent can be finely divided silica, boron nitride, clay, soap, poly(tetrafluoroethylene), clay, talc, silica, titanium dioxide, polydimethylsiloxane, polyurea, polyurethane, or combinations of two or more thereof.

Abstract: A composition is disclosed which comprises an aryl perfluoropolyether, optionally a halogenated oil, and further optionally a thickening agent. The composition can be used as a lubricant itself or as an additive to an oil or grease lubricant and can withstand temperatures higher than 300° C. without decomposition. The halogenated oil can be a perfluoropolyether, a fluorosilicone, a polytrifluorochloroethylene, or combinations of two or more thereof. The thickening agent can be finely divided silica, boron nitride, clay, soap, poly(tetrafluoroethylene), clay, talc, silica, titanium dioxide, polydimethylsiloxane, polyurea, polyurethane, or combinations of two or more thereof.

Abstract: A composition is disclosed which comprises an aryl perfluoropolyether, optionally a halogenated oil, and further optionally a thickening agent. The composition can be used as a lubricant itself or as an additive to an oil or grease lubricant and can withstand temperatures higher than 300° C. without decomposition. The halogenated oil can be a perfluoropolyether, a fluorosilicone, a polytrifluorochloroethylene, or combinations of two or more thereof. The thickening agent can be finely divided silica, boron nitride, clay, soap, poly(tetrafluoroethylene), clay, talc, silica, titanium dioxide, polydimethylsiloxane, polyurea, polyurethane, or combinations of two or more thereof.

Abstract: An InAsP active region for a long wavelength light emitting device and a method for growing the same are disclosed. In one embodiment, the method comprises placing a substrate in an organometallic vapor phase epitaxy (OMVPE) reactor, the substrate for supporting growth of an indium arsenide phosphide (InAsP) film, forming a quantum well layer of InAsP, and forming a barrier layer adjacent the quantum well layer, where the quantum well layer and the barrier layer are formed at a temperature of less than 520 degrees C. Forming the quantum well layer and the barrier layer at a temperature of less than 520 degrees C. results in fewer dislocations by suppressing relaxation of the layers. A long wavelength active region including InAsP quantum well layers and InGaP barrier layers is also disclosed.

Abstract: A perfluoropolyether, a composition comprising the perfluoropolyether, a process for producing the perfluoropolyether, and a process for improving the thermostability of grease or lubricant are provided. The perfluoropolyether comprises perfluoroalkyl radical end groups in which the radical has at least 3 carbon atoms per radical and is substantially free of perfluoromethyl and perfluoroethyl end groups. The process for producing the perfluoropolyether can comprise (1) contacting a perfluoro acid halide, a C2-to C4-substituted ethyl epoxide, or a C3+ fluoroketone with a metal halide to produce an alkoxide; (2) contacting the alkoxide with either hexafluoropropylene oxide or tetrafluorooxetane to produce a second acid halide; (3) esterifying the second acid halide to an ester; (4) reducing the ester to its corresponding alcohol; (5) converting the alcohol with a base to a salt form; (6) contacting the salt form with a C3 or higher olefin to produce a fluoropolyether; and (7) fluorinating the fluoropolyether.

Abstract: A composition that is or comprises a phosphorus-, perfluoropolyether-, and perfluoroalkyl-containing compound is provided. The compound comprises either (i) mono- or polyalkylene oxide linking groups between the phosphorus and the fluorocarbon group, or (ii) no linking group between the phosphorus and fluorocarbon group, or (iii) individual mixtures of (i) and (ii); and the fluorocarbon group can be the perfluoropolyether or perfluoroalkyl group. The compound can also be a partially esterified phosphate, a partially esterified phosphonate, a salt of a partially esterified phosphate, a salt of a partially esterified phosphonate, or mixtures of two or more thereof.