Patents by Inventor William Peter Van Antwerp

William Peter Van Antwerp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6852694
    Abstract: The present invention is directed to stabilized insulin composition comprising a mixture of insulin species such as insulin and an insulin analog. As disclosed herein, insulin compositions comprising a mixture of insulin and insulin analog species form heterodimeric complexes having a greater stability than the homodimeric complexes formed in compositions comprising single insulin species. Consequently, the present invention provides methods for stabilizing insulin molecules, methods for identifying stable heterodimeric insulin complexes and stabilized insulin compositions.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: February 8, 2005
    Assignee: Medtronic MiniMed, Inc.
    Inventors: William Peter Van Antwerp, Poonam S. Gulati
  • Patent number: 6804544
    Abstract: Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: October 12, 2004
    Assignee: MiniMed, Inc.
    Inventors: William Peter Van Antwerp, John Joseph Mastrototaro
  • Publication number: 20040171518
    Abstract: The present invention is directed to stabilized polypeptide compositions. Typical embodiments of the present invention provide improved methods and materials for maintaining the stability of insulin polypeptide formulations. In particular, the disclosure provided herein teaches that the aggregation of insulin polypeptides can be inhibited by combining them with a class of compounds having the general formula A1—L1—S—L2—A2, wherein S comprises from one to seven consecutive atoms selected from the group consisting of nitrogen, carbon, and oxygen, wherein at least one of the atoms is a carbon atom; L1 and L2 are linking groups having from two to twelve atoms selected from the group consisting of nitrogen, carbon, oxygen, sulfur, and phosphorus; and A1 and A2 are carboxylic acid groups.
    Type: Application
    Filed: February 27, 2003
    Publication date: September 2, 2004
    Applicant: Medtronic MiniMed, Inc.
    Inventors: William Peter Van Antwerp, Joseph C. Walsh
  • Patent number: 6784274
    Abstract: Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: August 31, 2004
    Assignee: Minimed Inc.
    Inventors: William Peter Van Antwerp, Christian C. Decker, John J. Mastrototoro
  • Patent number: 6766183
    Abstract: Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. Embodiments of these biosensor molecules exhibit fluorescence emission at wavelengths greater than about 650 nm. Typical biosensor molecules include a fluorophore that includes an iminium ion, a linker moiety that includes a group that is an anilinic type of relationship to the fluorophore and a boronate substrate recognition/binding moiety, which binds glucose. The fluorescence molecules modulated by the presence or absence of polyhydroxylated analytes such as glucose. This property of these molecules of the invention, as well as their ability to emit fluorescent light at greater than about 650 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: July 20, 2004
    Assignees: Medtronic MiniMed, Inc., The Regents of the University of California
    Inventors: Joseph C. Walsh, Aaron M. Heiss, Glenn Noronha, David J. Vachon, Stephen M. Lane, Joe H. Satcher, Jr., Thomas A. Peyser, William Peter Van Antwerp, John Joseph Mastrototaro
  • Patent number: 6750311
    Abstract: Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: June 15, 2004
    Assignees: MiniMed Inc., The Regents of the University of California
    Inventors: William Peter Van Antwerp, John Joseph Mastrototaro, Stephen M. Lane, Joe H. Satcher, Jr., Christopher B. Darrow, Thomas A. Peyser, Jennifer Harder
  • Patent number: 6734162
    Abstract: The present invention is a pharmaceutical composition for polypeptide which are not stably soluble. A preferred polypeptide is monomeric insulin and a preferred formulation consists of a TRIS-phosphate combination buffer, zinc; a phenolic preservative and an isotonicity agent such as glycerol.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: May 11, 2004
    Assignee: MiniMed Inc.
    Inventors: William Peter Van Antwerp, Poonam S. Gulati
  • Publication number: 20030069383
    Abstract: Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
    Type: Application
    Filed: August 6, 2002
    Publication date: April 10, 2003
    Inventors: William Peter Van Antwerp, Christian C. Decker, John J. Mastrototaro
  • Publication number: 20020193672
    Abstract: Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. Embodiments of these biosensor molecules exhibit fluorescence emission at wavelengths greater than about 650 nm. Typical biosensor molecules include a fluorophore that includes an iminium ion, a linker moiety that includes a group that is an anilinic type of relationship to the fluorophore and a boronate substrate recognition/binding moiety, which binds glucose. The fluorescence molecules modulated by the presence or absence of polyhydroxylated analytes such as glucose. This property of these molecules of the invention, as well as their ability to emit fluorescent light at greater than about 650 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.
    Type: Application
    Filed: December 28, 2001
    Publication date: December 19, 2002
    Inventors: Joseph C. Walsh, Aaron M. Heiss, Glenn Noronha, David J. Vachon, Stephen M. Lane, Joe H. Satcher, Thomas A. Peyser, William Peter Van Antwerp, John Joseph Mastrototaro
  • Patent number: 6462162
    Abstract: Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: October 8, 2002
    Assignee: MiniMed Inc.
    Inventors: William Peter Van Antwerp, Christian C. Decker, John J. Mastrototoro
  • Publication number: 20020132760
    Abstract: The present invention is directed to stabilized insulin composition comprising a mixture of insulin species such as insulin and an insulin analog. As disclosed herein, insulin compositions comprising a mixture of insulin and insulin analog species form heterodimeric complexes having a greater stability than the homodimeric complexes formed in compositions comprising single insulin species. Consequently, the present invention provides methods for stabilizing insulin molecules, methods for identifying stable heterodimeric insulin complexes and stabilized insulin compositions.
    Type: Application
    Filed: February 21, 2002
    Publication date: September 19, 2002
    Inventors: William Peter Van Antwerp, Poonam S. Gulati
  • Patent number: 6443942
    Abstract: The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medications. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such treated surfaces including the covalent attachment of hydrophilic surfactants.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: September 3, 2002
    Assignee: MiniMed, Inc.
    Inventors: William Peter Van Antwerp, Poonam S. Gulati, Gerald E. Adomian
  • Publication number: 20020018843
    Abstract: Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
    Type: Application
    Filed: August 21, 2001
    Publication date: February 14, 2002
    Applicant: Minimed Inc.
    Inventors: William Peter Van Antwerp, John Joseph Mastrotoaro
  • Publication number: 20010051277
    Abstract: The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medications. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such treated surfaces including the covalent attachment of hydrophilic surfactants.
    Type: Application
    Filed: June 6, 2001
    Publication date: December 13, 2001
    Applicant: MiniMed, Inc.
    Inventors: William Peter Van Antwerp, Poonam S. Gulati, Gerald E. Adomian
  • Patent number: 6319540
    Abstract: Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal. Specifically, the analyte transducer immobilized in a polymeric matrix can be a boronic acid moiety.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: November 20, 2001
    Assignee: MiniMed Inc.
    Inventors: William Peter Van Antwerp, John Joseph Mastrototaro
  • Publication number: 20010031726
    Abstract: The present invention is a pharmaceutical composition for polypeptdes which are not stably soluble. A preferred polypeptide is monomeric insulin and a preferred formulation consists of a TRIS-phosphate combination buffer, zinc; a phenolic preservative and an isotonicity agent such as glycerol.
    Type: Application
    Filed: December 8, 2000
    Publication date: October 18, 2001
    Applicant: MiniMed, Inc.
    Inventors: William Peter Van Antwerp, Poonam S. Gulati
  • Publication number: 20010008931
    Abstract: Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
    Type: Application
    Filed: July 28, 1998
    Publication date: July 19, 2001
    Inventors: WILLIAM PETER VAN ANTWERP, CHRISTIAN C. DECKER, JOHN J. MASTROTOTARO
  • Patent number: 6011984
    Abstract: Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: January 4, 2000
    Assignee: Minimed Inc.
    Inventors: William Peter Van Antwerp, John Joseph Mastrototaro
  • Patent number: 6002954
    Abstract: Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: December 14, 1999
    Assignees: The Regents of the University of California, Minimed Inc.
    Inventors: William Peter Van Antwerp, John Joseph Mastrototaro, Stephen M. Lane, Joe H. Satcher, Jr., Christopher B. Darrow, Thomas A. Peyser, Jennifer Harder
  • Patent number: 5786439
    Abstract: Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
    Type: Grant
    Filed: October 24, 1996
    Date of Patent: July 28, 1998
    Assignee: MiniMed Inc.
    Inventors: William Peter Van Antwerp, Christian C. Decker, John J. Mastrototaro