Abstract: Non-human identities (NHI) are present in many organizations. NHIs may be associated with automated processes, bots, devices, and so forth. NHIs may be involved in operations within an organization, as well as operations that interact with other organizations. The creation and management of NHIs differs from human identities. A system for managing NHIs ingests data from an existing system and determines the NHIs. Once determined, the system provides a single management point for NHIs, providing visibility and allowing management according to specified best practices appropriate to the organization. New NHIs may be provisioned as needed and with appropriate security permissions. Access credentials of NHIs may be rotated. Old, unused, or compromised NHIs may be quickly deprovisioned. Operations that are better performed by an NHI may be migrated from a human identity to the NHI, avoiding breakage due to changes in the human identity status.

Abstract: A set and release retainer valve assembly of an air brake system engages and releases an air brake while retaining a designated pressure within a brake cylinder. The pressure is retained within the brake cylinder to generate a higher brake cylinder pressure on a subsequent brake application and/or prevent movement of the vehicle system after release of the air brake system. The air brake is subsequently re-engaged to re-set the retaining valve assembly and exhaust the designated air pressure out of the brake cylinder, where the air brake of the vehicle system is released to permit the movement of the vehicle system after re-setting the retaining valve assembly.

Abstract: A brake health monitoring system and method measure pressures in different components of a brake system of a vehicle system during movement of the vehicle system. Two or more of the pressures that are measured in the different components are compared with each other to select a health monitoring mode. One or more allowable pressures are selected based on the health monitoring mode that is selected. A state of health of the brake system is determined by comparing one or more of the pressures that is measured with the one or more allowable pressures that are selected.

Abstract: A brake monitoring system monitors pressures in a brake system of a vehicle system at different locations in the vehicle system. Decreases in the pressures are determined at two or more of the different locations. The times at which the decreases in the pressures occurred are determined. A location of interest of a leak in the brake system is determined by comparing the times at which the decreases in the pressures occurred.

Abstract: A set and release retainer valve assembly of an air brake system engages and releases an air brake while retaining a designated pressure within a brake cylinder. The pressure is retained within the brake cylinder to generate a higher brake cylinder pressure on a subsequent brake application and/or prevent movement of the vehicle system after release of the air brake system. The air brake is subsequently re-engaged to re-set the retaining valve assembly and exhaust the designated air pressure out of the brake cylinder, where the air brake of the vehicle system is released to permit the movement of the vehicle system after re-setting the retaining valve assembly.

Abstract: A brake health monitoring system and method measure pressures in different components of a brake system of a vehicle system during movement of the vehicle system. Two or more of the pressures that are measured in the different components are compared with each other to select a health monitoring mode. One or more allowable pressures are selected based on the health monitoring mode that is selected. A state of health of the brake system is determined by comparing one or more of the pressures that is measured with the one or more allowable pressures that are selected.

Abstract: Systems and methods for coverage analysis using context information are described. The systems and methods can be used to obtain program code and test information for testing the program code, the test information associated with context information for providing context for testing the program code. Coverage information can be generated by testing the program code according to the test information. A first association can be generated between the context information and the test information. A second association can be generated between the context information and the program code. A third association can be generated between the coverage information and the test information. A subset of the coverage information can be determined based on the third association and a fourth association between the test information and the program code determined based on the first and second associations. An indication of the subset of the coverage information can be displayed.

Abstract: A brake monitoring system monitors pressures in a brake system of a vehicle system at different locations in the vehicle system. Decreases in the pressures are determined at two or more of the different locations. The times at which the decreases in the pressures occurred are determined. A location of interest of a leak in the brake system is determined by comparing the times at which the decreases in the pressures occurred.

Abstract: Systems and methods for coverage analysis using context information are described. The systems and methods can be used to obtain program code and test information for testing the program code, the test information associated with context information for providing context for testing the program code. Coverage information can be generated by testing the program code according to the test information. A first association can be generated between the context information and the test information. A second association can be generated between the context information and the program code. A third association can be generated between the coverage information and the test information. A subset of the coverage information can be determined based on the third association and a fourth association between the test information and the program code determined based on the first and second associations. An indication of the subset of the coverage information can be displayed.

Abstract: Tetrapyrrolic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl36H2O to oxidize the D ring and separating the resulting organic layer and drying.

Abstract: A separating device with integrated storage securing an electrical charging device and providing wire management for portable computers, such as notebook computers or laptop computers, in a cart, pedestal, desk-mounted depot, or similar devices is shown herein. Briefly stated, in its preferred embodiment, the separating device comprises a sheet of rigid material with a thin thickness cut in a roughly trapezoidal profile, a plurality of holes, a plurality of tabs, and a plurality of slots. The separating device is designed to accept a portable computing device and its charging device. Wires running from the charging device to the portable computing device are fed through the separating device for wire management. Wires running from the charging device to a power plug are wrapped around the separating device for further wire management. Also, the separating device may be attached to a device capable of accepting the separating device.

Abstract: Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl3.6H2O to oxidize the D ring and separating the resulting organic layer and drying.

Abstract: A compound having preferential localization in tumor tissue relative to normal tissue, a preferential electromagnetic absorption at a wavelength between about 660 and 900 nm, and a fluorescence at a wavelength shifted from the preferential absorption by at least +30 nm and preferably at least +50 nm. The compound further preferably destroys tumor tissue in which it is absorbed when exposed to light at its preferential absorption wavelength. In a preferred embodiment of the invention, the compound is a conjugate of a tumor avid tetrapyrrole compound with a fluorescent dye, and more preferably the fluorescent dye is an indocyanine dye such as indocyanine green. The tumor avid tetrapyrrole compound is preferably a porphyrin derivative selected from the group consisting of chlorins, bacteriochlorins, purpurins and derivatives thereof.

Abstract: A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1—R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.

Abstract: A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.

Abstract: A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.

Abstract: A separating device with integrated storage securing an electrical charging device and providing wire management for portable computers, such as notebook computers or laptop computers, in a cart, pedestal, desk-mounted depot, or similar devices is shown herein. Briefly stated, in its preferred embodiment, the separating device comprises a sheet of rigid material with a thin thickness cut in a roughly trapezoidal profile, a plurality of holes, a plurality of tabs, and a plurality of slots. The separating device is designed to accept a portable computing device and its charging device. Wires running from the charging device to the portable computing device are fed through the separating device for wire management. Wires running from the charging device to a power plug are wrapped around the separating device for further wire management. Also, the separating device may be attached to a device capable of accepting the separating device.

Abstract: A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a phamaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted —CH2CH2CON(CH2CON(CH2COOH)2)2; or —N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.

Abstract: A compound having preferential localization in tumor tissue relative to normal tissue, a preferential electromagnetic absorption at a wavelength between about 660 and 900 nm, and a fluorescence at a wavelength shifted from the preferential absorption by at least +30 nm and preferably at least +50 nm. The compound further preferably destroys tumor tissue in which it is absorbed when exposed to light at its preferential absorption wavelength. In a preferred embodiment of the invention, the compound is a conjugate of a tumor avid tetrapyrrole compound with a fluorescent dye, and more preferably the fluorescent dye is an indocyanine dye such as indocyanine green. The tumor avid tetrapyrrole compound is preferably a porphyrin derivative selected from the group consisting of chlorins, bacteriochlorins, purpurins and derivatives thereof.

Abstract: According to the invention there is provided a medical device capable of releasing a medically active ingredient, said device including a blend of: (i) a carrier polymer or a blend of carrier polymers; (ii) a medically active ingredient; and, optionally, (iii) a water sensitive polymer for releasing said medically active ingredient in the presence of water and/or a pH sensitive polymer for releasing said medically active ingredient in the presence of a solution having a pH within a predetermined range; with the proviso that, if component (iii) is absent, the carrier polymer includes an ethylene vinyl alcohol copolymer.